Aplastic Anemia in Children
What is aplastic anemia in children?
Aplastic anemia is a serious condition in which the bone marrow doesn’t make enough
new blood cells. With fewer blood cells, a child with aplastic anemia has:
Less oxygen sent to organs, tissues, and cells (from too few red blood cells)
Increased risk of infection (from too few white blood cells)
Increased risk of bleeding problems (from too few platelets)
What causes aplastic anemia in a child?
Aplastic anemia in children has many causes. Sometimes the cause is unknown. There
are many known causes. Aplastic anemia may develop it at some point during childhood.
Or it may be passed down from parent to child.
Acquired causes include:
Infection.These include hepatitis or liver infection, and many different viral illnesses, such
as Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19, or human immunodeficiency
Cancer. Some cancers affect the bone marrow.
Autoimmune disease. These include lupus and rheumatoid arthritis.
Medicines. This includes some antibiotics and other medicines.
Toxins. These include heavy metals, pesticides, and benzene.
Radiation therapy and chemotherapy. These are done to treat cancer.
What are the symptoms of aplastic anemia in a child?
The most common symptoms of aplastic anemia are below.
Low levels of red blood cells can cause:
Irregular heart beat
Low levels of white blood cells can cause:
Low levels of platelets can cause:
Other symptoms can include:
The symptoms of aplastic anemia may look like other blood disorders or medical problems.
Always check with your child's doctor for a diagnosis.
How is aplastic anemia diagnosed in a child?
Your child's healthcare provider will likely refer your child to a hematologist, an
expert in blood disorders. Along with a complete medical history and physical exam
of your child, tests for aplastic anemia may include:
Hemoglobin and hematocrit. This blood test measures the amount of hemoglobin, the part of red blood cells that
carry oxygen, and red blood cells in the blood.
Complete blood count (CBC). A complete blood count checks the red and white blood cells, blood clotting cells
(platelets), and sometimes, young red blood cells (reticulocytes). It includes hemoglobin
and hematocrit and more details about the red blood cells.
Peripheral smear. A small sample of blood is examined under a microscope. Blood cells are checked to
see if they look normal or not.
Bone marrow aspiration or biopsy. This procedure is done by taking a small amount of bone marrow fluid (aspiration)
or solid bone marrow tissue, called a core biopsy. The hip bone is often used. The
fluid and tissue are examined for the number, size, and maturity of blood cells or
How is aplastic anemia treated in a child?
Treatment will depend on your child’s symptoms, age, general health, and how severe
the condition is. Treatment for aplastic anemia also depends on the cause. For mild
aplastic anemia, treatment may not be needed. Treatment may include:
What are possible complications of aplastic anemia in a child?
With correct treatment, the risk of complications will be reduced for children with
Complications of aplastic anemia include:
How can I help my child live with aplastic anemia?
Work with your child's healthcare provider to develop a treatment plan.
Try to make your child's life as normal as possible.
Remember to also pay attention to other children in the family.
Work closely with your child’s school to make sure he or she gets what is needed.
Your child may also qualify for special programs under Section 504 of the Rehabilitation
Act of 1973.
If your child feels different or alone, find a support group for children with anemia.
Your child should not do activities that increase the chance of infection or bleeding.
These activities include things like:
Staying away from people who are sick
Eating uncooked foods
Contact sports (for example, football, hockey, skiing, or rollerblading)
Traveling to high altitudes (children with a low red blood cell count will have increased
fatigue and need for oxygen in high altitudes)
When should I call my child's healthcare provider?
Each child is different based on how severe their symptoms are and what treatment
they may be getting. Talk with your child's healthcare provider about when you should
call. For instance, you may be instructed to call if your child has:
Signs of infection, such as a fever, or flu-like symptoms
Bleeding that you can't control
Key points about aplastic anemia in children
Aplastic anemia is a serious condition in which the bone marrow does not produce enough
new blood cells.
It may be passed down from the parents or develop sometime during childhood.
Some symptoms include tiredness, paleness, frequent infections, and easy bruising
Aplastic anemia is diagnosed with blood and bone marrow tests.
Treatment depends on the cause. It may include blood transfusions, medicines, and
stem cell transplantation.
Tips to help you get the most from a visit to your child’s healthcare provider:
Know the reason for the visit and what you want to happen.
Before your visit, write down questions you want answered.
At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you for your child.
Know why a new medicine or treatment is prescribed and how it will help your child.
Also know what the side effects are.
Ask if your child’s condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if your child does not take the medicine or have the test or procedure.
If your child has a follow-up appointment, write down the date, time, and purpose
for that visit.
Know how you can contact your child’s provider after office hours. This is important
if your child becomes ill and you have questions or need advice.