Chorionic Villus Sampling
What is chorionic villus sampling (CVS)?
Chorionic villus sampling (CVS) is a test done early in a woman’s pregnancy. CVS checks
for genetic problems in your baby. During CVS, your healthcare provider takes a small
piece of tissue from the placenta for testing. The placenta is an organ that grows
in the uterus during pregnancy. This tissue has the same genetic material as your
baby. It can show if your baby is developing problems as it grows.
Why might I need chorionic villus sampling?
Women who have a higher risk or a family history of genetic problems may want to consider
CVS testing. Your healthcare provider may recommend CVS if:
- You are age 35 or older
- You have a family history of a genetic disorder such as Down syndrome, Tay Sachs disease,
or cystic fibrosis
- You and your husband are carriers for genetic disorders
- Blood tests or ultrasounds during pregnancy show that your unborn baby is at increased
risk of having a genetic disorder
The results of CVS are usually available earlier in pregnancy, compared with some
other genetic tests, such as amniocentesis. Amniocentesis uses a needle to get samples
of amniotic fluid. But CVS is not as accurate as amniocentesis. Other first trimester
screening tests provide similar information to CVS, and may be used instead of CVS.
What are the risks of chorionic villus sampling?
Talk about the risks and benefits of CVS with your healthcare provider. The risks
of CVS include:
- Infection from the procedure, or passed from mother to baby
Another risk is fetal blood mixing with the mother’s blood. This may result in the
mother's immune system destroying fetal blood. This problem is called Rh factor incompatibility.
Mothers are given a medicine called Rh immunoglobulin after the procedure to prevent
this from happening.
Some women may not be able to have CVS. For example, if you have a vaginal infection
such as herpes or gonorrhea.
How do I get ready for chorionic villus sampling?
CVS is usually done during the first trimester, after 10 weeks of pregnancy. Your
healthcare provider will give you instructions. You will likely need a full bladder
for the test. Drink plenty of water and don’t urinate before the test. You will also
have an ultrasound before the test. This is a procedure that uses sound waves and
a computer to make images on a screen.
What happens during chorionic villus sampling?
The test can be done through your belly (transabdominal). Or it may be done through
your cervix (transcervical). It is common to feel some cramping during and after the
For transcervical CVS
- The healthcare provider moves a small tube (catheter) through your vagina and cervix
to the uterus.
- The provider uses ultrasound to guide the catheter into place near the placenta.
- The provider takes a tissue sample using a tiny syringe at the end of the catheter.
For transabdominal CVS
- The healthcare provider puts a needle through your belly (abdomen) and into the uterus.
- The provider uses ultrasound to guide the needle into place near the placenta.
- The provider takes a small amount of tissue with the syringe.
Women who are pregnant with several babies may need to have tissue taken from each
placenta. But CVS is not always successful in women with more than one baby. This
is because the position of the babies in the uterus can make it hard to get a tissue
What happens after chorionic villus sampling?
The tissue samples are sent to a lab to be checked. Early results may be available
in 48 hours. Final results are usually ready in about 7 to 10 days.
After the procedure, call your healthcare provider if:
- You have bleeding
- You have fluid leaking from your vagina
- You have cramps that are getting worse
- You have a fever of 100.4 degrees F (38 degrees C) or higher
Before you agree to the test or the procedure make sure you know:
- The name of the test or procedure
- The reason you are having the test or procedure
- What results to expect and what they mean
- The risks and benefits of the test or procedure
- What the possible side effects or complications are
- When and where you are to have the test or procedure
- Who will do the test or procedure and what that person’s qualifications are
- What would happen if you did not have the test or procedure
- Any alternative tests or procedures to think about
- When and how will you get the results
- Who to call after the test or procedure if you have questions or problems
- How much will you have to pay for the test or procedure