Rhabdomyosarcoma in Children
What is rhabdomyosarcoma in children?
Rhabdomyosarcoma is a type of cancer. It starts in cells that grow into skeletal muscle
cells. The cells are called rhabdomyoblasts. Skeletal muscles control all of a person’s
voluntary muscle movements. The cancer is most common in children under age 10, but
it is rare. It can form anywhere in the body. The most common places are:
- Head and neck, such as near an eye, in the throat, or in the sinuses
- Urinary and reproductive organs, such as the bladder, prostate gland, or any female
- Arms and legs
- Chest and belly (abdomen)
There are 2 main types of rhabdomyosarcoma:
- Embryonal. This is the most common type. It’s more common in younger children.
- Alveolar. This is more common in older children and teenagers. This type grows more quickly.
It’s more likely to spread to other areas of the body (metastasize).
What causes rhabdomyosarcoma in children?
The exact cause of rhabdomyosarcoma is not known. Changes in the genetic material
in cells (DNA) may cause the cells to turn into cancer.
Who is at risk for rhabdomyosarcoma?
Some health conditions that are passed down through families (genetic) increase a
child's risk. These include:
- Li-Fraumeni syndrome
- Beckwith-Wiedemann syndrome
- Costello syndrome
What are the symptoms of rhabdomyosarcoma in children?
Symptoms depend on the location and the size and of the tumor. There may be no symptoms
until the tumor is very large. The main symptom may be a lump or swelling that may
be painful. Other symptoms can occur a bit differently in each child.
A growth near the eye can cause:
- Bulging eye
- Trouble with vision
A growth in the ear or sinuses can cause:
- Ear pain
- Sinus congestion
A growth in the urinary or reproductive organs can cause:
- Pain when urinating
- Pain with bowel movements
A growth in the abdomen can cause:
- Trouble having bowel movements (constipation)
Symptoms of advanced rhabdomyosarcoma may include:
- Bone pain
- Weight loss
The symptoms of rhabdomyosarcoma can be like other health conditions. Make sure your
child sees a healthcare provider for a diagnosis.
How is rhabdomyosarcoma in children diagnosed?
Your child's healthcare provider will ask about your child's health history and symptoms.
He or she will examine your child. Your child may be referred to a child cancer specialist
(pediatric oncologist). Your child may have tests such as:
- Blood and urine tests. Blood and urine are tested in a lab.
- X-ray. An X-ray uses a small amount of radiation to take pictures of bones and other body
- CT scan. This test uses a series of X-rays and a computer to make detailed images of the body.
- MRI. This test uses large magnets, radio waves, and a computer to make detailed images
of the inside of the body.
- Ultrasound (sonography). This test uses sound waves and a computer to create images.
- Bone scan. A small amount of dye is injected into a vein. The whole body is scanned. The dye
shows up in areas where there may be cancer.
- Positron emission tomography (PET) scan. For this test, a radioactive sugar is injected into the bloodstream. Cancer cells
use more sugar than normal cells, so the sugar will collect in cancer cells. A special
camera is used to see where the radioactive sugar is in the body. A PET scan can sometimes
spot cancer cells in different areas of the body, even when they can’t be seen by
other tests. This test is often used in combination with a CT scan. This is called
a PET/CT scan.
- Tumor biopsy. A sample of the tumor is taken. It may be taken with a needle or by a surgical cut
(incision). It is checked under a microscope for cancer cells. A biopsy is the only
way to know for sure if the tumor is cancer.
- Bone marrow aspiration or biopsy. Bone marrow is found in the center of some bones. It’s where blood cells are made. A small
amount of bone marrow fluid may be taken. This is called aspiration. Or solid bone
marrow tissue may be taken. This is called a core biopsy. Bone marrow is usually taken from
the hip bone. This test may be done to see if cancer cells have reached the bone marrow.
- Lumbar puncture. A special needle is placed into the lower back, into the spinal canal. This is the
area around the spinal cord. This is done to check the brain and spinal cord for cancer
cells. A small amount of cerebral spinal fluid (CSF) is removed and sent for testing.
CSF is the fluid around the brain and spinal cord. This test may be done for rhabdomyosarcoma
of the head and neck.
Part of diagnosing cancer is called staging. Staging is the process of seeing if the
cancer has spread, and where it has spread. Staging also helps to decide the treatment.
There are different ways of staging cancer, but most range from stage 1 to stage 4.
Talk with your child's healthcare provider about the stage of your child's cancer
and what it means.
How is rhabdomyosarcoma in children treated?
Treatment will depend on the location, stage, and other factors. The cancer can be
treated with any of the below:
- Surgery. The goal of surgery is to fully remove the tumor. This is called resection. The surgery
will be done to avoid loss of function and deformation as possible. A surgeon who
specializes in the body area of tumor growth may be needed. This may be a head and
face (craniofacial) surgeon, or an ear, nose, and throat (otolaryngologist) doctor.
It may be a brain surgeon (neurosurgeon) or bone doctor (orthopedist). Or it may be
another type of doctor.
- Chemotherapy. These are medicines that kill cancer cells. They are always used to treat rhabdomyosarcoma. Some medicines may
be given by mouth. But most are given through a vein (IV).
- Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill
cancer cells or stop them from growing. It may be used when a tumor is hard to remove
with surgery. Radiation therapy is usually given along with chemotherapy.
- Clinical trials. Ask your child's healthcare provider if there are any treatments being tested that
may work well for your child.
- Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for
pain, fever, infection, and nausea and vomiting.
With any cancer, how well a child is expected to recover (prognosis) varies. Keep
- Getting medical treatment right away is important for the best prognosis. Cancer that
has spread is harder to treat.
- Ongoing follow-up care during and after treatment is needed.
- New treatments are being tested to improve outcome and to lessen side effects.
What are possible complications of rhabdomyosarcoma in children?
A child may have complications from the tumor or from treatment. They may include:
- Damage to the brain or nervous system that causes problems with coordination, muscle
strength, speech, or eyesight
- Problems after surgery, such as infection, bleeding, and problems with general anesthesia
- Infection and bleeding from chemotherapy
- Delayed growth and development
- Learning problems
- Problems with reproduction (infertility)
- Return of the cancer
- Growth of other cancers
How is rhabdomyosarcoma in children managed?
A child with rhabdomyosarcoma needs ongoing care. Your child will be seen by oncologists
and other healthcare providers to treat any late effects of treatment and to watch
for signs or symptoms of the tumor returning. Your child will be checked with imaging
tests and other tests. And your child may see other healthcare providers for problems
from the tumor or from treatment. For example, your child may see an eye doctor (ophthalmologist)
for vision problems.
Your child may need therapy to help with movement and muscle strength. This may be
done by physical and occupational therapists. If your child's speech is affected,
he or she may need help from a speech therapist. Your child may also need the help
of other therapists for learning or emotional problems.
You can help your child manage his or her treatment in many ways. For example:
- Your child may have trouble eating. A dietitian may be able to help.
- Your child may be very tired. He or she will need to balance rest and activity. Encourage
your child to get some exercise. This is good for overall health. And it may help
to lessen tiredness.
- If your child smokes, help him or her quit. If your child doesn’t smoke, make sure
he or she knows the danger of smoking.
- Get emotional support for your child. Find a counselor or child support group can
- Make sure your child attends all follow-up appointments.
When should I call my child’s healthcare provider?
Call the healthcare provider if your child has:
- Symptoms that get worse
- New symptoms
- Side effects from treatment
Key points about rhabdomyosarcoma in children
- Rhabdomyosarcoma is a rare type of cancer that starts in the cells that develop into
skeletal muscle cells (rhabdomyoblasts). These are the muscles that your child controls
- It can occur almost anywhere in the body. The most common places are the head and
neck; urinary and reproductive organs; arms and legs; and chest and belly (abdomen).
- Symptoms depend on the size and the location of the tumor. A lump or swelling, pain,
bleeding, trouble urinating or having bowel movement are some symptoms.
- Tests include different imaging studies and biopsy of the tumor.
- Treatment includes surgery, chemotherapy, and radiation therapy.
- Ongoing follow-up care during and after treatment is needed.
Tips to help you get the most from a visit to your child’s healthcare provider:
- Before your visit, write down questions you want answered.
- At the visit, write down the names of new medicines, treatments, or tests, and any
new instructions your provider gives you for your child.
- If your child has a follow-up appointment, write down the date, time, and purpose
for that visit.
- Know how you can contact your child’s provider after office hours. This is important
if your child becomes ill and you have questions or need advice.