Glomerulonephritis in Children
What is glomerulonephritis in children?
The kidneys contain many coils of tiny blood vessels. Each of these is called a glomerulus.
Glomeruli filter substances from the blood into the urine. Glomerulonephritis is a
type of kidney disease where these coils become inflamed. This makes it hard for the
kidneys to filter the blood.
What causes glomerulonephritis in a child?
Glomerulonephritis can be caused by diseases such as:
Systemic autoimmune diseases. With these types of diseases, the body’s immune system attacks healthy cells by mistake.
Systemic means that many parts of the body are affected. An example of this is systemic
lupus erythematosus (SLE or lupus).
Polyarteritis nodosa. This is an inflammatory disease of the arteries.
Granulomatosis with polyangiitis. This is a progressive disease that leads to widespread inflammation of all of the
Henoch-Schönlein purpura. This disease causes small or large purple lesions (purpura) on the skin and internal
organs. It causes other symptoms in several organ systems.
Alport syndrome. This is a form of inherited glomerulonephritis that affects both boys and girls.
But boys are more likely to have kidney problems. Treatment focuses on preventing
and treating high blood pressure and preventing kidney damage.
Streptococcal infection. In children, glomerulonephritis is often caused by strep throat or an upper respiratory
infection. The disease usually occurs 1 week or more after an infection.
Hepatitis B. This infection can be passed from mother to baby or rarely contracted
through a blood transfusion.
Which children are at risk for glomerulonephritis?
A child is more at risk for glomerulonephritis if he or she has:
What are the symptoms of glomerulonephritis in a child?
Symptoms can occur a bit differently in each child. They can include:
Urine that is dark brown, from blood and protein
Lack of energy or tiring easily (fatigue)
High blood pressure
Seizures from high blood pressure
Rash, especially over the buttocks and legs
Pale skin color
Fluid buildup in the tissues (edema)
The symptoms of glomerulonephritis can be like other health conditions. Make sure
your child sees his or her healthcare provider for a diagnosis.
How is glomerulonephritis diagnosed in a child?
The healthcare provider will ask about your child’s symptoms and health history. He
or she may also ask about your family’s health history. He or she will give your child
a physical exam. Your child may also have tests, such as:
Throat culture. This may be done to check for strep throat. A swab is gently wiped in your child’s
throat to collect bacteria.
Blood tests. These look at blood cell counts, electrolyte levels, and kidney function.
Urine test. This test looks for protein and blood in urine and other problems.
Electrocardiogram (ECG). This is a test that records the electrical activity of the heart, shows abnormal
heart rhythms, and detects heart muscle damage.
Renal ultrasound (sonography). This is a painless test that uses sound waves and a computer to create images of body
tissues. During the test, a healthcare provider moves a device called a transducer
over the belly in the kidney area. This sends a picture of the kidney to a video screen.
The healthcare provider can see the size and shape of the kidney. He or she can also
see a growth, kidney stone, cyst, or other problems.
Chest X-ray. This test uses a small amount of radiation to make images of tissues, bones, and
organs on film.
Renal biopsy. The healthcare provider takes a small sample of kidney tissue. This is done through
the skin with a needle or during surgery. The sample is looked at under a microscope.
How is glomerulonephritis treated in a child?
Most children with kidney disease see both a pediatrician or family healthcare provider
and a nephrologist. A nephrologist is a healthcare provider with special training
to treat kidney problems.
Treatment will depend on your child’s symptoms, age, and general health. It will also
depend on the severity of the condition and the cause. Treatments focus on slowing
the progression of the disease and preventing complications.
Treatment may include changes to your child’s diet. Your child may need to limit:
Protein. Protein is vital for proper growth and nutrition. But the kidneys may not be able
to get rid of the waste products that come from eating too much protein. Your child's
healthcare provider will talk with you about how much protein your child needs.
Potassium. Potassium is an important nutrient. But when the kidneys don’t work well, too much
potassium can build up in the blood. Potassium comes from certain foods. Your child
may need to limit or not eat foods with a lot of potassium.
Phosphorus. The kidneys help remove excess phosphorus from the body. If the kidneys are not working
well, too much phosphorus builds up in the blood and can cause calcium to leave the
bones. This can make your child's bones weak and easy to break. Your child may need
to limit foods with phosphorus.
Sodium. A low-sodium diet can help prevent or reduce fluid retention in your child's body.
The healthcare provider will talk with you about the amount of sodium allowed in your
Treatment may include medicines to:
Increase urination (diuretic)
Reduce blood pressure
Lower the amount of the mineral phosphorus in the blood (phosphate binders)
Lessen the body’s immune system response (immunosuppressive medicine)
In some cases, a child may develop severe problems with electrolytes. This may cause
dangerous levels of waste products in the blood that are normally removed by the kidneys.
A child may also develop fluid overload. A child may need dialysis in these cases.
Dialysis is a procedure that filters waste and extra fluid from the blood. This is
normally done by the kidneys. There are 2 types of dialysis.
This can be done at home. This method uses the lining of the belly (abdominal) cavity
to filter the blood. This cavity is the space that holds organs such as the stomach,
intestines, and liver. The lining is called the peritoneum.
First, a surgeon places a thin, flexible tube (catheter) into your child’s belly.
After the tube is placed, a sterile cleansing fluid (dialysate) is put through the
catheter into the peritoneal cavity. The fluid is left in the belly for a period of
time. This fluid absorbs the waste products through the peritoneum. The fluid is then
drained from the belly, measured, and discarded. This process of filling and draining
fluid is called an exchange.
This is done in a dialysis center or hospital by healthcare providers. A special type
of access, called an arteriovenous (AV) fistula, is placed during a small surgery.
This fistula is an artery and a vein that are joined together. It is usually done
in your child's arm. An external IV (intravenous) catheter may also be inserted. This
is less common for long-term dialysis.
Your child will then be connected to a large hemodialysis machine. Blood is pumped
through a tube into the machine to filter out the wastes and extra fluid. The filtered
blood then flows through another tube back into your child's body.
Hemodialysis is usually done several times a week. Each session lasts for 4 to 5 hours.
It may be helpful to bring games or reading materials for your child to keep him or
her busy during this procedure.
Talk with your child’s healthcare providers about the risks, benefits, and possible
side effects of all treatments.
What are possible complications of glomerulonephritis in a child?
If glomerulonephritis does not go away, it may lead to kidney failure.
When should I call my child’s healthcare provider?
Call the healthcare provider if your child has:
Key points about glomerulonephritis in children
The kidneys contain many tiny coils of blood vessels called glomeruli. Glomerulonephritis
is a type of kidney disease where these become inflamed. The disease makes it hard
for the kidneys to filter the blood.
The condition has many possible causes, such as an autoimmune disease or an infection.
Symptoms can include dark brown urine, less urine, and low energy.
Treatment may include changes in diet, medicines, or dialysis.
If glomerulonephritis does not go away, it may lead to kidney failure.
Tips to help you get the most from a visit to your child’s healthcare provider:
Know the reason for the visit and what you want to happen.
Before your visit, write down questions you want answered.
At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you for your child.
Know why a new medicine or treatment is prescribed and how it will help your child.
Also know what the side effects are.
Ask if your child’s condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if your child does not take the medicine or have the test or procedure.
If your child has a follow-up appointment, write down the date, time, and purpose
for that visit.
Know how you can contact your child’s provider after office hours. This is important
if your child becomes ill and you have questions or need advice.