What is a kidney transplant?
A kidney transplant is a surgery done to replace a diseased kidney with a healthy
kidney from a donor. The kidney may come from a deceased organ donor or from a living
donor. Family members or others who are a good match may be able to donate one of
their kidneys. This type of transplant is called a living transplant. People who donate
a kidney can live healthy lives with one healthy kidney.
A person getting a transplant most often gets just 1 kidney. In rare situations, he
or she may get 2 kidneys from a deceased donor. The diseased kidneys are usually left
in place. The transplanted kidney is placed in the lower belly on the front side of
Why might I need a kidney transplant?
You may need a kidney transplant if you have end stage renal disease (ESRD). This
is a permanent condition of kidney failure. It often needs dialysis. This is a process
used to remove wastes and other substances from the blood.
- Remove urea and liquid waste from the blood in the form of urine. Urea is made when
foods containing protein, such as meat, poultry, and certain vegetables, are broken
down in the body. Urea is carried in the blood to the kidneys.
- Balance salts, electrolytes, such as potassium and sodium, and other substances in
- Produce erythropoietin, a hormone that aids the formation of red blood cells
- Regulate blood pressure
- Regulate fluid and acid-base balance in the body to keep it neutral. This is needed
for normal function of many processes within the body
Some conditions of the kidneys that may result in ESRD include:
- Repeated urinary infections
- Kidney failure caused by diabetes or high blood pressure
- Polycystic kidney disease or other inherited disorders
- Glomerulonephritis, which is inflammation of the kidney's filtering units
- Hemolytic uremic syndrome, a rare disorder that causes kidney failure
- Lupus and other diseases of the immune system
Other conditions, such as congenital defects of the kidneys, may result in the need
for a kidney transplant.
There may be other reasons for your healthcare provider to recommend a kidney transplant.
What are the risks for kidney transplant?
As with any surgery, complications can occur. Some complications may include:
- Blockage of the blood vessels to the new kidney
- Leakage of urine or blockage of urine in the ureter
- Lack of function of the new kidney at first
The new kidney may be rejected. Rejection is a normal reaction of the body to a foreign
object or tissue. When a new kidney is transplanted into a recipient's body, the immune
system reacts to what it thinks as a threat and attacks the new organ. For a transplanted
organ to survive, medicines must be taken to trick the immune system into accepting
the transplant and not attacking it as a foreign object.
The medicines used to prevent or treat rejection have side effects. The exact side
effects will depend on the specific medicines that are taken.
Not everyone is a candidate for kidney transplantation. You may not be eligible if
- Current or recurring infection that cannot be treated effectively
- Cancer that has spread from its original location to elsewhere in the body
- Severe heart or other health problems that make it unsafe to have surgery
- Serious conditions other than kidney disease that would not get better after transplantation
- Failing to follow the treatment plan
There may be other risks depending on your specific medical condition. Be sure to
discuss any concerns with your transplant team before the procedure.
How do I prepare for a kidney transplant?
To get a kidney from an organ donor who has died (cadaver), you must be placed on
a waiting list of the United Network for Organ Sharing (UNOS). Extensive testing must
be done before you can be placed on the transplant list.
A transplant team carries out the evaluation process for a kidney. The team includes
a transplant surgeon, a transplant nephrologist (healthcare provider specializing
in the treatment of the kidneys), one or more transplant nurses, a social worker,
and a psychiatrist or psychologist. Other team members may include a dietitian, a
chaplain, and/or an anesthesiologist.
The evaluation includes:
- Mental health evaluation. Psychological and social issues involved in organ transplantation, such as stress,
financial issues, and support by family and/or significant others are assessed. These
issues can greatly affect the outcome of a transplant. The same kind of evaluation
is done for a living donor.
- Blood tests. Blood tests are done to help find a good donor match, to check your priority on the
donor list, and to help the chances that the donor organ will not be rejected.
- Diagnostic tests. Diagnostic tests may be done to check your kidneys as well as your overall health
status. These tests may include X-rays, ultrasound, kidney biopsy, and dental exams.
Women may get a Pap test, gynecology evaluation, and a mammogram.
The transplant team will weigh all the facts from interviews, your medical history,
physical exam, and tests to determine your eligibility for kidney transplantation.
Once you have been accepted as a transplant candidate, you will be placed on the UNOS
list. When a donor organ becomes available, you will be notified and told to come
to the hospital right away.
If you are to get a kidney from a living family member (living-related transplant),
the transplant may be done at a planned time. The donor must have a compatible blood
type and be in good health. A mental health check will be done to be sure the donor
is comfortable with the decision.
These steps will happen before the transplant:
- Your transplant team will explain the procedure to you and you can ask questions.
- You will be asked to sign a consent form that gives your permission to do the surgery.
Read the form carefully and ask questions if something is not clear.
- If you have been on routine dialysis before the procedure, you will get dialysis before
- For a planned living transplant, you should fast for 8 hours before the operation,
generally after midnight. In the case of a cadaver organ transplant, you should start
to fast once you are told a kidney has become available.
- You may get a sedative before the procedure to help you relax.
- Based on your medical condition, your transplant team may ask for other specific preparation.
What happens during a kidney transplant?
A kidney transplant requires a stay in a hospital. Procedures may vary depending on
your condition and your healthcare provider's practices.
Generally, a kidney transplant follows this process:
- You will remove your clothing and put on a hospital gown.
- An intravenous (IV) line will be started in your arm or hand. More catheters may be
put in your neck and wrist to monitor the status of your heart and blood pressure,
and to take blood samples. Other sites for catheters include under the collarbone
area and the groin blood vessels.
- If there is too much hair at the surgical site, it may be shaved off.
- A urinary catheter will be inserted into your bladder.
- You will be positioned on the operating table, lying on your back.
- Kidney transplant surgery will be done while you are asleep under general anesthesia.
A tube will be inserted through your mouth into your lungs. The tube will be attached
to a ventilator that will breathe for you during the procedure.
- The anesthesiologist will closely watch your heart rate, blood pressure, breathing,
and blood oxygen level during the surgery.
- The skin over the surgical site will be cleansed with an antiseptic solution.
- The healthcare provider will make a long incision into the lower abdomen on one side.
The healthcare provider will visually inspect the donor kidney before implanting it.
- The donor kidney will be placed into the belly. A left donor kidney will be implanted
on your right side; a right donor kidney will be implanted on your left side. This
allows the ureter to be accessed easily for connection to your bladder.
- The renal artery and vein of the donor kidney will be sewn to the external iliac artery
- After the artery and vein are attached, the blood flow through these vessels will
be checked for bleeding at the suture lines.
- The donor ureter (the tube that drains urine from the kidney) will be connected to
- The incision will be closed with stitches or surgical staples.
- A drain may be placed in the incision site to reduce swelling.
- A sterile bandage or dressing will be applied.
Talk with your healthcare provider about what you will go through during your kidney
What happens after a kidney transplant?
In the hospital
- After the surgery, you will be taken to the recovery room. Once your blood pressure,
pulse, and breathing are stable and you are alert, you may be taken to the intensive
care unit (ICU) for close monitoring. In time, you will be moved out of the ICU to
a regular nursing unit as you recover and you are closer to going home. Kidney transplant
usually calls for several days in the hospital.
- A kidney from a living donor may start to make urine right away. Urine production
in a cadaver kidney may take longer. You may need to continue dialysis until urine
output is normal.
- You will have a catheter in your bladder to drain your urine. The amount of urine
will be measured to check how the new kidney is working.
- You will get IV fluids until you are able to eat and drink enough on your own.
- Your team will closely watch how your antirejection medicines are working to make
sure you are getting the best dose and the best combination of medicines.
- Blood samples will be taken often to check the status of the new kidney, as well as
other body functions, such as the liver, lungs, and blood system.
- You will slowly move from liquids to more solid foods as tolerated. Your fluids may
be limited until the new kidney is working fully.
- Usually, by the day after the procedure you may start moving around. You should get
out of bed and move around several times a day.
- Take a pain reliever for soreness as advised by your healthcare provider. Avoid aspirin
or certain other pain medicines that may increase the chance of bleeding. Be sure
to take only recommended medicines.
- Nurses, pharmacists, dietitians, physical therapists, and other members of the transplant
team will teach you how to take care of yourself once you are discharged from the
hospital including care for your incisions.
- You will be ready to go home when your vital signs are stable, the new kidney is working,
and you do not need the constant hospital care.
- Once you are home, it is important to keep the surgical area clean and dry. Your healthcare
provider will give you specific bathing instructions. Generally, the incision should
not be submerged in water until the skin heals as this increases the risk for infection.
The stitches or surgical staples will be removed during a follow-up office visit.
- You should not drive until your healthcare provider tells you it’s OK. Plan to have
someone drive you home from the hospital and to your follow-up appointments.
- Avoid any activity or position that causes pressure to be placed on the new kidney.
Other activity restrictions may apply.
- Check your blood pressure and weight at home every day. Increases in these may mean
your kidneys are not filtering fluid properly. You need to be seen by your transplant
Tell your healthcare provider if you have:
- Fever, which may be a sign of rejection or infection
- Redness, swelling, or bleeding or other drainage from the incision site
- Increase in pain around the incision site, which may be a sign of rejection or infection
Fever and tenderness over the kidney are some of the most common symptoms of rejection.
A rise in your blood creatinine level (blood test to measure kidney function) and/or
blood pressure may also suggest rejection. The symptoms of rejection may look like
other medical conditions or problems. Talk with your transplant team with any concerns
you have. Frequent visits to and contact with the transplant team are vital.
Avoid places in which you may be exposed to anyone who may be sick. This is because
your immune system will be suppressed to protect you from rejecting the new kidney.
This will be a lifelong precaution.
Your healthcare team may give you other instructions after the procedure, depending
on your situation.
What is done to prevent rejection
To allow the transplanted kidney to survive in your body, you will be given medicines
for the rest of your life to fight rejection. Each person may react differently to
New antirejection medicines are continually being developed and approved. Your healthcare
team will tailor medicine regimes to meet your needs.
Usually several antirejection medicines are given at first. The doses of these medicines
may change often, depending on your response. Because antirejection medicines affect
the immune system you will be at higher risk for infections. A balance must be maintained
between preventing rejection and making you very susceptible to infection.
Some of the infections you will be especially at risk for include oral yeast infection
(thrush), herpes, and respiratory viruses. Avoid contact with crowds and anyone who
has an infection for the first few months after your surgery.
Before you agree to the test or the procedure make sure you know:
- The name of the test or procedure
- The reason you are having the test or procedure
- What results to expect and what they mean
- The risks and benefits of the test or procedure
- What the possible side effects or complications are
- When and where you are to have the test or procedure
- Who will do the test or procedure and what that person’s qualifications are
- What would happen if you did not have the test or procedure
- Any alternative tests or procedures to think about
- When and how will you get the results
- Who to call after the test or procedure if you have questions or problems
- How much will you have to pay for the test or procedure