Skip to main content

Coronavirus (COVID-19): Visitor Restrictions, Resources, and Updates

Explore URMC
URMC / Encyclopedia / Content

Leukemia: Risk Factors

Woman smoking a cigarette.

What is a risk factor?

A risk factor is anything that may increase your chance of having a disease. Risk factors for a certain type of cancer might include smoking, diet, family history, or many other things. The exact cause of someone’s cancer may not be known. But risk factors can make it more likely for a person to have cancer.

Things you should know about risk factors for cancer:

  • Risk factors can increase a person's risk, but they do not necessarily cause the disease.

  • Some people with one or more risk factors never develop cancer. Other people can develop cancer and have no risk factors.

  • Some risk factors are very well known. But there is ongoing research about risk factors for many types of cancer.

Some risk factors, such as family history, may not be in your control. But others may be things you can change. Knowing the risk factors can help you make choices that might lower your risk. For example, if smoking is a risk factor, you may choose to quit smoking.

Who is at risk for leukemia?

Anyone can get leukemia. In many people the cause of their leukemia is not known. But some risk factors for leukemia are known.


People who smoke are more likely to get acute myeloid leukemia (AML) than people who do not smoke.

Exposure to certain chemicals

Being exposed to certain chemicals has been linked with some types of leukemia. For example, exposure to benzene is a risk factor for AML. It may also be a risk factor for acute lymphocytic leukemia (ALL). Exposure to Agent Orange, an herbicide used in the Vietnam War, has been linked to an increased risk for chronic lymphocytic leukemia (CLL).

Chemotherapy in the past

People who get certain chemotherapy medicines to treat other cancers are more likely to get AML or ALL later on. A person's risk for leukemia is higher for a number of years after the first cancer is treated. But this small increased risk of getting leukemia later on does not outweigh the need to use these medicines to treat the cancer.

Radiation exposure

High doses of radiation raise a person's risk for AML, ALL, and chronic myeloid leukemia (CML). This exposure could be from an atomic bomb blast or a nuclear reactor accident, as well as from radiation therapy to treat another type of cancer.

Rare congenital diseases

A small number of people are at greater risk for AML and ALL because they have certain rare diseases from the time they are born. For example, people with Down syndrome, ataxia-telangiectasia, and Bloom syndrome have an increased risk of getting these acute forms of leukemia.

Certain blood disorders

People who have certain blood diseases are more likely to get AML. These diseases include myelodysplastic syndromes. 

Family history

Most people who get leukemia do not have a family history of it. But people with relatives who have AML or CLL may be at increased risk.


Most types of leukemia, especially chronic leukemias, become more common as people get older. But ALL is more common in children than in adults.


Most types of leukemia are slightly more common in males than in females. Doctors do not know why this is so. 

What are your risk factors?

Talk with your healthcare provider about your risk factors for leukemia and what you can do about them. 

Medical Reviewers:

  • Gersten, Todd, MD
  • Stump-Sutliff, Kim, RN, MSN, AOCNS