Kaposi Sarcoma: Surgery and Other Local Treatments
Surgery and other types of local treatment can sometimes be used to remove or destroy
Kaposi sarcoma (KS) lesions. Local treatments are those that treat only a specific
area of the body, as opposed to treating the whole body.
When might surgery or other local treatments be used for Kaposi sarcoma?
Local treatments are sometimes used to treat 1 or more KS lesions that are grouped
in a small area of the body. The goal of this treatment is to remove or destroy the
lesions to help a person look better, or to ease symptoms caused by the lesions. A
downside to local treatments is that they can't stop new KS lesions from forming in
other parts of the body.
Types of local treatments for Kaposi sarcoma
Several types of local treatments can be used for KS lesions.
Removing the lesions with surgery is sometimes an option. There are 2 main ways to
remove KS lesions:
Simple excision. In this approach, the skin is numbed and the lesion (and a small area of skin
around it) is removed with a surgical knife.
Curettage and electrodesiccation. In this procedure, the skin is numbed and the lesion is removed with a sharp,
spoon-shaped tool called a curette. An electric current is then applied to the
area to stop bleeding and destroy any remaining cancer cells.
For this treatment, very cold liquid nitrogen is applied to the lesion to freeze and
kill the cancer cells. This approach is most useful for small lesions on the face.
It can be repeated if needed.
Photodynamic therapy (PDT)
In this treatment, a liquid medicine is applied directly to the lesion. It collects
in the cancer cells and makes them more sensitive to certain kinds of light. The cells
are given time to absorb the medicine. Then a special light is applied to the cells,
which kills them. This treatment can make the area very sensitive to sunlight for
a time. So it is very important to keep the area covered up.
Topical retinoid therapy
For this treatment, a type of medicine called a retinoid, which is related to vitamin
A, is applied directly to the lesion. It can shrink the lesion over time. The medicine
used most often is alitretinoin. A drawback of this treatment is that it can cause
the area to become red and swollen, which limits its use.
Some KS lesions can be treated by injecting them with a small amount of chemotherapy
medicine (usually vinblastine). This can cause the lesion to shrink over time. This
treatment might need to be repeated. Side effects can include swelling and blistering.
High-energy X-rays or other types of radiation can be used to treat some KS lesions,
especially if they are larger and unlikely to be helped by other local treatments.
This type of treatment is discussed in more detail on a separate page.
Talk to your healthcare team
If you have any questions about your treatment, be sure to talk to your healthcare
team. They can help you know what to expect before, during, and after your procedure.