What is diabetes insipidus?
Diabetes insipidus occurs when your
body doesn’t make enough antidiuretic hormone (ADH). Or your kidneys don’t respond
it. ADH is a hormone that helps keep the right amount of water in your body. It does
this by controlling how much urine your kidneys put out. ADH is made by a small gland
at the base of the brain (hypothalamus). It is stored in the pituitary gland. It's
into the bloodstream when your body's fluid level is low. This keeps you from losing
much water (dehydrated). If you are a bit dehydrated, ADH should increase.
Diabetes insipidus is not related
to the more common type of diabetes (diabetes mellitus).
What causes diabetes insipidus?
There are several types of diabetes insipidus:
Central. This is when the pituitary
doesn’t make or send out enough ADH. It can happen if the hypothalamus or pituitary
gland are damaged. That can be caused by a head wound, including surgery on the
pituitary gland. It can also be cause by a genetic problem or other diseases.
Nephrogenic. This is when the kidneys
don’t respond to normal levels of ADH. It can be caused by medicines, or lifelong
(chronic) disorders such as kidney disease or sickle cell disease. It can also be
caused by low potassium or high calcium levels in the blood.
Dipsogenic. This is when there is
damage to the mechanism that controls thirst, found in the hypothalamus. You are then
too thirsty and drink too many fluids. This slows down ADH production.
Gestational. This occurs only in
pregnant women. In this type, an enzyme made by the placenta destroys ADH in the
What are the symptoms of diabetes insipidus?
Common symptoms may include:
Being very thirsty
Urinating a lot
These symptoms may look like other health problems. Always see your healthcare provider
for a diagnosis.
How is diabetes insipidus diagnosed?
Your provider will take your health history and give you a physical exam. You may
also need the following tests:
Blood tests to see how your pituitary
and kidneys react to dehydration. This is called a formal water deprivation test.
you may have an IV infusion of a concentrated salt solution.
CT scan or MRI. You may need this to see if you have a
structural problem in the hypothalamus or pituitary gland.
How is diabetes insipidus treated?
Treatment will depend on your symptoms, age, and general health. It
will also depend on how severe the condition is.
Treatment for diabetes insipidus
depends on what is causing it:
types. You need to have specific amount of fluid to prevent dehydration.
central and gestational types. Treatment may include taking modified ADH
medicines or medicines to stimulate ADH production.
nephrogenic diabetes insipidus. Other medicines may be used.
dipsogenic diabetes insipidus. There is no known treatment that works. .
What are possible complications of diabetes insipidus?
If you don’t drink enough fluids, you can get dehydrated. You can also have an electrolyte
imbalance. This means not having the right balance of minerals in your body.
Dehydration can cause:
Dry mouth, nose, and sinuses
Fast heart rate
Eyes can look sunken
Weight loss and weakness especially
Electrolyte imbalance can cause:
Living with diabetes insipidus
It’s important to follow your
healthcare provider’s instructions about medicines and fluid intake to prevent
When should I call my healthcare provider?
If your symptoms get worse or you have new symptoms, call your healthcare provider
Key points about diabetes insipidus
Diabetes insipidus occurs when your body doesn’t make enough antidiuretic hormone
(ADH). It is a rare disease that causes you to urinate often.
It is not related to the more common type of diabetes (diabetes mellitus).
Symptoms may include extreme thirst and urine production, and dehydration.
You may need to have blood tests and urine tests.
Treatment depends on what is causing
the disease. It may include replacing ADH with medicines.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells
At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed, and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your provider if you have questions.