Shuyuan Yeh Lab

Shuyuan Yeh


Dr. Shuyuan Yeh

Professor of Urology and of Pathology and Laboratory Medicine

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Dr. Shuyuan Yeh Publications

(Total 98 Articles including: 1 Lancet, 1 Nature Medicine, 1 Science
Translational Medicine, 1 JEM, 1 JNCI, 1 Gastroenterology, 21 PNAS, 4 Cancer Research, 3 Oncogene, 4 Clinical Cancer Research, 5 Endocrinology, 8 JBC, 4 MCB, 1 Diabetes, 1 Hepatology and others in Cancer and/or Endocrinology related journals.) *24 corresponding author papers and 21 first author papers

(PDF files are available when you click individual publication)

  • A. Estrogen Receptor, Vitamin E analogs and TAP Related Publication (Total: 27)
  1. Zhang Y, Ni J, Chang E, Messing EM, Yang CR and Yeh S*. (2002) “Alpha-Vitamin E succinate Inhibits of the Function of AR and the Expression of PSA in Prostate Cancer Cells. Proc Natl Acad Sci. USA 99: 7408-7413. PMID: 12032296
  2. Yeh S, Wang MS, Su CY, Yang CY. (2002) Nature Products and Environmental Androgens and Antiandrogens. Kluwer Academic Publishers. Chapter 7, pp213-244, Review
  3. Ni J, Chen M, Zhang Y, Li R, Huang J, and Yeh S*. (2003) “Alpha-Vitamin E succinate regulates cell cycle related genes in prostate cancer cells” Biochem Biophys Res Commun. 300:357-63. PMID: 12504091
  4. Zhang M, Altuwaijri S, and Yeh S*. (2004) “RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness.” Oncogene 23(17): 3080-8. PMID: 15048090
  5. Wu Y, Zu K, Ni J, Yeh S, Kasi D, James NS, Chemler SR and Ip C. (2004) “Cellular and Molecular Effects of alpha-Tocopheryloxybutyrate: Lessons for the Design of Vitamin E Analog for Cancer Prevention” Anticancer Research 24: 3795-3802. PMID: 15736414
  6. Ni J Wen X, Yao J, Chang H, Yi Y, Xie S, Chen M, Di’Santagenese A, Messing EM and Yeh S*. (2005) “Tocopherol associated protein inhibits the prostate cancer through inhibition of PI3 kinase pathway” Cancer Research 65(21): 9807-16. PMID: 16267002
  7. Li R, Ni J, Bourne PA, Yeh S, Yao J, di Sant'Agnese PA, Huang J. Cell culture block array for immunocytochemical study of protein expression in cultured cells. Appl Immunohistochem Mol Morphol. 2005 Mar;13(1):85-90. PMID: 15722799
  8. Yeh, S*, Chen, M., Ni, J., Yin, Y., Chang, C., Zhang, M., and Wen, X. (2005) Functions of Estrogen Receptor in Prostate and Prostate Cancer. In: Prostate Cancer: Basic Mechanisms and Therapeutic Approaches., New Jersey World Scientific Publishing, pp293-313.
  9. Yeh S*, Ni J, Chang E, Yin Y, and Chen M. (2005) Roles of Vitamin E in Prostate and Prostate Cancer. In: Prostate Cancer: Basic Mechanisms and Therapeutic Approaches, New Jersey World Scientific Publishing, pp263-76.
  10. Chang, E., Ni, J., Yin, Y., Chang, P., James, N., Chemler, S., and Yeh, S*. (2007)?alpha-Vitamin E Derivative, ?alpha-tocpheryloxybutyric acid (TOB), Inhibits the Proliferation of Prostate Cancer Cells. Asian J Androl. 9(1):31-39. PMID: 1718715
  11. Ni J, Pang ST, Yeh S*. (2007) “Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. Prostate 67(5):463-471. PMID: 17252538
  12. Yi Y, Ni J, Chen M, DiMaggio MA, Gao Y, and Yeh S*. (2007) The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostate cancer via induction of insulin-like growth factor binding protein-3.” Clinical Cancer Res. 2007; 13 (7):2271-80. PMID: 17404112
  13. Ni J and Yeh S*. (2007) “The roles of alpha-Vitamin E and its analogs in prostate cancer” Vitamins and Hormones, Vol 76, SPI Publisher Service, Elsevier (Editor: Gerald Litwack) Volume 76, Chapter 19. pp 493-518. PMID: 17628187
  14. Chen M, Ni J, Zhang Y, Muyan M, and Yeh S*. ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. Prostate 2008 Sep 1;68 (12):1273-82. PMID: 18563714
  15. Yin Y, Ni J, Chen M, Guo Y, and Yeh S*. (2009) RRR-?-Vitamin E Succinate Potentiates the Antitumor Effect of Calcitriol in Prostate Cancer without Overt Side Effects. Clin Cancer Res. 15(1):190-200. PMID: 19118046
  16. Chen M, Wolfe A, Wang X, Chang C, Radovick S* and Yeh S*. (2009) Generation and Characterization of a Complete Null Estrogen Receptor alpha Mouse using Cre/LoxP Technology. Mol Cell Biochem. 321(1-2):145-53. PMID: 18953638
  17. Chen M, Hsu I, Wolfe A, Radovick S, Huang KH, Yu S, Chang C, Messing EM, and Yeh S*. (2009) Defects of Prostate Development and Reproductive System in the ER? Null Male Mice. Endocrinology 150(1):251-9. PMID: 18755802
  18. Ni J, Mai T, Pang ST, Haque I, Huang K, DiMaggio MA, Xie S, James NS, Kasi D, Chemler SR*, and Yeh S*. (2009) In vitro and in vivo anticancer effects of the novel vitamin E ether analogue RRR-alpha-tocopheryloxybutyl sulfonic acid in prostate cancer. Clin. Cancer Res. 15(3):898-906. PMID: 19188160
  19. Chen M, Ni J, Chang HC, Lin CY, Muyan M, and Yeh S*. CCDC62/ERAP75 Functions as a Coactivator to Enhance Estrogen Receptor beta-Mediated Transactivation and Target Gene Expression in Prostate Cancer Cells. Carcinogenesis. 2009 May;30(5):841-50. PMID: 19126643
  20. Wang X, Ni J, Hsu CL, Johnykutty S, Tang P, Ho YS, Lee CH, Yeh S*. Reduced Expression of Tocopherol-Associated Protein (TAP/Sec14L2) in Human Breast Cancer. Cancer Invest. 27(10):971-7; 2009 Jun 22 [Epub ahead of print] PMID: 19548139
  21. Johnykutty S, Tang P, Zhao H, Hicks DG, Yeh S, Wang X. Dual expression of alpha-tocopherol-associated protein and estrogen receptor in normal/benign human breast luminal cells and the downregulation of alpha-tocopherol-associated protein in estrogen-receptor-positive breast carcinomas. Mod Pathol. 22(6):770-5. 2009 Mar 20. PMID: 19305383
  22. Nott SL, Huang Y, Li X, Fluharty BR, Qiu X, Welshons WV, Yeh S, Muyan M. Genomic responses from the estrogen responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations. J Biol Chem. 284(22):15277-88. 2009, Mar 24. [Epub ahead of print] PMID: 19321454
  23. Chen M and Yeh S*. “Estrogens and Estrogen Receptors in Prostate Development, Estrogenization, and Carcinogenesis” Nova Book: Female Sex Hormones and Cancers: Chapter 11, pp209-234, 2010. (Editor: George G. Chen).
  24. Miyamoto H, Yao JL, Chaux AM, Zheng Y, Hsu I, Izumi K, Chang C, Messing EM, Netto GJ, and Yeh S*. Expression of androgen and estrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder. BJU Int. 2012  Jun;109(11):1716-26
  25. Chen M, Yeh CR, Chang HC, Slavin S, Wen XQ, Wolfe A, and Yeh S*." Prostate epithelial ERa plays critical roles in squamous metaplasia evident by tissue selective ERKO mouse model". J Pathol. 2012 Jan;226(1):17-27.
  26. Chen M, Yeh CR, Shyr CR, Lin HH, Da J, Yeh S..Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. Asian J Androl. 2012 Jul;14(4):546-55.
  27. Vitkus S, Yeh CR, Lin HH, Hsu I, Yu J, Chen M, Yeh S ."Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development". Mol Endocrinol. 2013 Jan;27(1):38-49
  28. Hsu I, Vitkus S, Da J, Yeh S "Role of oestrogen receptors in bladder cancer development" (Nat Rev Urol. 2013 Jun;10(6):317-26)
  29. Hsu I, Chuang KL, Slavin S, da J, Lim WX, Pang ST, O'Brien JH, Yeh S "Suppression of ERβ signaling via ERβ knockout or antagonist protects against bladder cancer development". Carcinogenesis. 2014 Mar;35(3):651-61
  30. Guancial EA, Bellmunt J, Yeh S, Rosenberg JE, Berman DM The evolving understanding of microRNA in bladder cancer. Urol Oncol. 2014 Jan;32(1):41.e31-40.
  31. Slavin S, Yeh CR, Da J, Yu S, Miyamoto H, Messing EM, Guancial E and Yeh S "Estrogen receptor α in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3". Carcinogenesis. 2014 Feb 17
  • AR, AR coregulators, ARKO related publications (73 publications)
  1. Mizokami A, Yeh SY, Chang C. Identification of 3',5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter. Mol Endocrinol. (1994) Jan;8(1):77-88.

  2. Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci U S A. (1994) Jun 21;91(13):6040-4.

  3. Ideta R, Yeh S, Lee YF, Adachi K, Takeda H, Su C, Saltzman A and Chang C "Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily." Endocrine,(1995), 3, 277-283.

  4. Chang C, Saltzman A, Yeh S, Young W-J, Keller E, Lee H-J, Wang C, and Mizokami A "Androgen receptors: an overview." Critical Review in Eukaryotic Gene Expression,(1995), 5(2), 97-126.

  5. Yeh S and Chang C." Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A. (1996) ;93(11):5517-21.
  6. Yeh S, Miyamoto H, Chang C. "Hydroxyflutamide may not always be a pure antiandrogen". Lancet. (1997); 349(9055):852-3.

  7. Yeh S and Chang C. "ARA70, the first specific co-activator for the androgen receptor in human prostate cells." Worldwide Documents in Prostatic Cancer & BPH (1997). 5:2-3.

  8. Yeh S, and Chang C "The effect of androgens and 17b-estradiol on the androgen receptor transcriptional activity in the presence of the androgen receptor coactivator ARA70 in human prostate DU145 cells." from: Current Advances in Andrology (1997) (Waites G. Frick J and Baker G ed) pp. 17-22 Monduzzi Editore Italy.

  9. Miyamoto H, Yeh S, Fujimoto N, Hsiao P, Nishimura K, Hsu J, Ting H, Inui S, Chang C. "Androgen receptor and androgen receptor co-factors in prostate." Proc. Jap. Nat. Conf. Andrology. (1997),1-4.

  10. Yeh S, Miyamoto H, Huang S, Fugimoto N, Hsiao P, Ting H, Inui S, Nishimura K, Wang C, Uemura H, Kang H, and Chang C "Androgen Receptor Coregulators: in: Molecular Basis of Sex Hormone Receptor Function "(1998), (Gornemeyer H, Fugymann U, and Parczyk ed) 43-53, Springer Berlin.
  11. Yeh S, Miyamoto H, Shima H, Chang C. "From estrogen to androgen receptor: a new pathway for sex hormones in prostate". Proc Natl Acad Sci U S A. (1998); 95(10):5527-32.

  12. Miyamoto H, Yeh S, Wilding G, Chang C. "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc Natl Acad Sci U S A. (1998) ;95(13):7379-84.
  13. Yeh S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, Chang C. Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. Biochem Biophys Res Commun. (1998) ;248(2):361-7.

  14. Miyamoto H, Yeh S, Lardy H, Messing E, Chang C. "Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells". Proc Natl Acad Sci U S A. (1998) ;95(19):11083-8.

  15. Yeh S, Kang HY,Fujimoto N, Chang C. "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J Biol Chem. (1999) ;274(13):8570-6.
  16. Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C. "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". J Biol Chem. (1999); 274(12):8316-21.
  17. Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen D J, and Boothman, D. A. (1999) Isolation of Ku70-Binding Proteins (KUBs). Nucleic Acid Research 27: 2165-2174. PMID: 10219089
  18. Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C. "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc Natl Acad Sci U S A. (1999) ;96(10):5458-63.
  19. Heinlein CA, Ting HJ, Yeh S, Chang C. "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J Biol Chem. (1999) ;274(23):16147-52.
  20. Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang H, Thin T, Lin D, and Chang C "Differential induction of androgen receptor transcriptional activity by selective androgen receptor coactivators." Keio J. of Medicine, (1999), 48, 87-92.

  21. Chang HC, Miyamoto H, Marwah P, Lardy H, Yeh S, Huang KE, Chang C. "Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells". Proc Natl Acad Sci U S A. (1999) ;96(20):11173-7.
  22. Yeh S, Kang HY, Miyamoto H, Nishimura K, Chang HC, Ting HJ, Rahman M, Lin HK, Fujimoto N, Hu YC, Mizokami A, Huang KE, Chang C. "Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells". Endocrine. (1999), (2):195-202.
  23. Yeh S, Hu YC, Rahman M, Lin HK, Hsu CL, Ting HJ, Kang HY, Chang C. "Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells". Proc Natl Acad Sci U S A. (2000); 97(21):11256-61.

  24. Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, Chang HC, Altuwaijri S, Huang KE, Chang C. "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer". J Formos Med Assoc. (2000); 99(12):885-94.

  25. Nishimura K, Sampson E, Yan S, Kim E, Wang X, Uemura H, Wang C, Fujimoto N, Kang H, Yeh S, and Chang C "Yeast two-hybrid screening of associated proteins and characterization of mutant androgen receptors." (2000), 329-343 in Yeast Hybrid Technologies (Zhu L and Hannon G ed). Eaton Publishing.

  26. Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C. "From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells". Proc Natl Acad Sci U S A. (2001), 98(6):3018-23.

  27. Lin HK, Yeh S, Kang HY, Chang C. "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc Natl Acad Sci U S A. (2001), 98(13):7200-5.

  28. Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C. "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". J Biol Chem. (2001), 276(44):40417-23.

  29. Sampson ER, Yeh S, Chang HC, Tsai MY, Wang X, Ting HJ, Chang C. "Identification and characterization of AR associated coregulators in prostate cancer cells". J Biol Regul Homeost Agents. (2001), 15(2):123-9.

  30. Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C. "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J Biol Chem. (2002), 277(7):4609-17.

  31. Ting HJ, Yeh S, Nishimura K, Chang C. "Supervillin associates with androgen receptor and modulates its transcriptional activity". Proc Natl Acad Sci U S A. (2002), 99(2):661-6.

  32. Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C. "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". J Biol Chem. (2002), 277(18):15426-31.
  33. Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C. Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation. J Biol Chem.
    (2002), 277(39):36499-508.

  34. Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC. "Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues". Proc Natl Acad Sci U S A. (2002), 99(21):13498-503.

  35. Rahman MM, Miyamoto H, Takatera H, Yeh S, Altuwaijri S, Chang C. "Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells". J Biol Chem. 2003 May 30;278(22):19619-26. Epub 2003 Mar 20.

  36. Hsu CL, Chen YL, Yeh S, Ting HJ, Hu YC, Lin H, Wang X, Chang C. "The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs". J Biol Chem. (2003), 278(26):23691-8.
  37. Nishimura K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Miyamoto H, Shin M, Aozasa K, Okuyama A, Chang C. "Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator". Cancer Res. (2003), 63(16):4888-94.

  38. Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett LA, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, Chang C. "Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells". Cancer Res. (2003), 63(21):7106-12.
  39. Yeh S, Hu YC, Wang PH, Xie C, Xu Q, Tsai MY, Dong Z, Wang RS, Lee TH, Chang C. "Abnormal Mammary Gland Development and Growth Retardation in Female Mice and MCF7 Breast Cancer Cells Lacking Androgen Receptor". J Exp Med. (2003), 198(12):1899-908.

  40. Collins LL, Lee HJ, Chen YT, Chang M, Hsu HY, Yeh S, Chang C. "The androgen receptor in spermatogenesis". Cytogenet Genome Res. (2003), 103(3-4):299-301.

  41. Zhang Y, Yang Y, Yeh S, Chang C. "ARA67/PAT1 functions as a repressor to suppress androgen receptor transactivation". Mol Cell Biol. (2004), 24(3):1044-57.

  42. Hu YC, Wang PH, Yeh S, Wang RS, Xie C, Xu Q, Zhou X, Chao HT, Tsai MY, Chang C. "Subfertility and defective folliculogenesis in female mice lacking androgen receptor". Proc Natl Acad Sci U S A. (2004), 101(31):11209-14.

  43. Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Keng P, Chang C. "Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells". Mol Cell Biol. (2004), 24(5):2202-13.

  44. Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H, Yeh S. "Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells" Proc Natl Acad Sci U S A. (2004), 101(18):6876-81.

  45. Yeh S, Hu YC,Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. "Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer". J Biol Chem. (2004), 279(32):33438-46.
  46. Altuwaijri S, Lee DK, Chuang KH, Ting HJ, Yang Z, Xu Q, Tsai MY, Yeh S, Hanchett LA, Chang HC, Chang C. "Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types". Endocrine. (2004), 25(1):27-32.

  47. Hsu CL, Chen YL, Ting HJ, Lin WJ, Yang Z, Zhang Y, Wang L, Wu CT, Chang HC, Yeh S, Pimplikar SW, Chang C. "Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth". Mol Endocrinol. (2005), 19(2):350-61.

  48. Cai G, Huang H, Shapiro E, Zhou H, Yeh S, Melamed J, Greco MA, Lee P. "Expression of androgen receptor associated protein 55 (ARA55) in the developing human fetal prostate". J Urol. (2005), 173(6):2190-3.

  49. Lin HY, Xu Q, Yeh S, Wang RS, Sparks JD, Chang C. "Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor". Diabetes. (2005), 54(6):1717-25.

  50. Wu CT, Yeh S, Xu Q, Yang Z, Chang P, Hu Y, Chang C. "Study of Androgen-Androgen Receptor Roles in Prostate Cancer using Mice Lacking Functional Prostate Androgen Receptor" in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. World Scientific Publishing: New Jersey, (2005), 383-92.

  51. Wang RS, Yeh S, Chen LM, Lin HY, Zhang C, Ni J, Wu CC, di Sant'Agnese PA, deMesy-Bentley KL, Tzeng CR, Chang C. "Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes". Endocrinology.(2006), 147(12):5624-33.

  52. Yeh S, Zhang C,Chen YT, Wu CC, Chuang KH, Lin HY, Wang RS, Chang YJ, Mendis-Handagama C, Hu L, Lardy H, Chang C. Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells. Proc Natl Acad Sci U S A.(2006), 103(47):17718-23.
  53. Tsai MY, Yeh SD, Wang RS, Yeh S, Zhang C, Lin HY, Tzeng CR, Chang C. "Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells". Proc Natl Acad Sci U S A.(2006), 103(50):18975-80.

  54. Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant'agnese PA, Tsai MY, Chang C. "Suppression of Androgen Receptor Transactivation and Prostate Cancer Cell Growth by Heterogeneous Nuclear Ribonucleoprotein A1 via Interaction with ndrogen recepotr coregulator ARA54". Endocrinology, (2007), 148(3):1340-9.

  55. Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C."ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor". Nat Med. (2007), 13(3):348-53.

  56. Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, Yeh S, Messing EM, Chang C.Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. (2007), 99(7):558-68.

  57. Wu CT, Altuwaijri S, Ricke WA, Huang SP, Yeh S, Zhang C, Niu Y, Tsai MY, and Chang C "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor" Proc Natl Acad Sci U S A (2007)104(31):12679-12684

  58. Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S, Chang C. "Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells". Endocrine. (2007), 32(1):96-106.

  59. Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C. "Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue". Endocrinology. (2008), 149(5):2361-8.

  60. Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C. "Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor". Hepatology. (2008), 47(6):1924-35.

  61. Ma WL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S and Chang C "Androgen Receptor Is a New Potential Therapeutic Target for the
    Treatment of Hepatocellular Carcinoma", Gastroenterology, (2008):135(3):947-55. PMID:18639661. NIHMS#69375,
  62. Niu Y, Altuwaijri S, Yeh S, Lai KP, Yu S, Chuang KH, Huang SP, Lardy H and Chang C "Targeting the stromal androgen receptor in primary prostate tumors at earlier stages" PNAS, (2008):105(34):12188-93. PMID:18723670. PMC2527887.
  63. Niu Y, Altuwaijri S, Lai KP, Wu CT, Ricke WA, Messing EM, Yao J, Yeh S* and Chang C "Androgen receptor is a tumor suppressor and proliferator in prostate cancer", PNAS, (2008):105(34):12182-7. PMID:18723679. PMC2527886.*co-correspondence
  64. Niu Y, Yeh S, Miyamoto H, Li G, Altuwaijri S, Yuan J, Han R, Ma T, Kuo HC and Chang C "Tissue prostate specific antigen (PSA) facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation" Cancer Research., (2008):68: (17), 7110-19. PMID:1857426. PMC2587124. NIHMSID # 58471.

  65. Yu SQ, Lai KP, Xia SJ, Chang HC, Chang C and Yeh S. "The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cance" AJA. (2008):11(1):39-48.PMID: 19098932.

  66. Altuwaijri S, Chuang KH, Lai KP, Lai JJ, Lin HY, Young FM, Bottaro A, Tsai MY, Yeh S and Chang C “Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells” Mol. Endo. (2009); 23(4):444-53. PMID: 19164450

  67. Wang RS, Yeh S, Tzeng CR, and Chang C “Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice” Endocr Rev. (2009); 30(2):119-32. PMID: 19176467

  68. Yeh S, Niu Y, Miyamoto H, Chang T and Chang C (2009) “Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression” pp 73-89 in Androgen Action in Prostate Cancer, (Tindall D and Mohler J ed): World Scientific. USA.

  69. Shyr CR, Tsai MY, Yeh S, Kang HY, Chang YC, Wong PL, Huang CC, Huang KE, Chang C. Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth. Prostate. 2010 Feb 1;70(2):190-9. PMID: 20044217
  70. Wu MH, Ma WL, Hsu CL, Chen YL, Ou J. JH, Ryan CK, Hung YC, Yeh S, and Chang C. Androgen Receptor Promotes Hepatitis B Virus-induced Hepatocarcinogenesis Through Modulation of Hepatitis B Virus RNA Transcription. Sci Transl Med. 2010 May 19;2(32):32ra35. PMID: 20484730
  71. Niu Y, Chang TM, Yeh S, Ma WL, Wang YZ, Chang C. Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails. Oncogene. 2010 29(25): 3593-604. 2010 May 3. [Epub ahead of print] PMID: 20440270
  72. Yu SQ, Zhang C, Lin CC, Niu Y, Lai KP, Chang HC, Yeh SD, Chang C, and Yeh S. Altered prostate epithelial development and IGF-1 signal in mice lacking the androgen receptor in stromal smooth muscle cells. Prostate 2011 Apr;71(5):517-24 PMID: 20945497
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Shu-Yuan Yeh
University of Rochester
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Rochester, NY 14642

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