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Dr. Chang's Publications

Total 390 published papers: including 1NatureMedicine/2Science-ScienceTM/1Lancet/2JCI-JNCI/2JEM/5EMBO-MolMed/27PNAS/50JBC/10MCB/10Cancer Research and >200 in Endocrinology or Cancer related Journals. . Citation indices from Google Scholar: (see Citation indices below )



Since 2009











Please see detail of each published papers in PubMed. For 38 AR review articles, please see below for PDF files.

1.AR Reviews


  1. Yeh S, Lee SO and Chang C “Targeting androgens vs androgen receptor to battle prostate cancer” , (2014) submitted
  2. Lin WJ, Izumi K, Lai KP and Chang C ",Androgen receptor (AR) roles in inflammation-related chronic prostatitis, BPH and prostate cancer" (2014) submitted
  3. Huang CK, Luo J, Lee SO and Chang C "Androgen Receptor Roles in Stem/Progenitor Cells Including Prostate, Embryonic, Stromal, and Hematopoietic lineages".Stem Cells (2014) 2014 Apr 16. doi: 10.1002/stem.1722. PMID: 24740898
  4. Ma WL, Lai HC, Yeh S, Cai X and Chang C “Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis” Endocr Relat Cancer. 2014 Jan 14. [Epub ahead of print] PMID: 24424503
  5. Chang C, Lee SO, Yeh S and Chang TM “Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells” Nuclear Receptor Signaling, (2013) 11:e001, PMID: 24653668; PMCID:PMC3960937
  6. Chang C, Lee SO, Yeh and Chang TM “Androgen receptor physiological roles in male and female reproductive system: what we learned from ARKO mice lack AR in selective cells” Biol Reprod (2013) 89(1):21. PMID:23782840
  7. Chang C, Lee SO, Yeh S and Chang TM “Androgen Receptor (AR) Roles in Hormone-related Tumors including Prostate, Bladder, Kidney, Lung, Breast and Liver” Oncogene, (2013), PMID: 23873027
  8. Wen S, Niu Y, Lee SO, and Chang C “Androgen Receptor Positive vs Negative Roles in Prostate Cancer Cell Death including Apoptosis, Anoikis, Entosis, Necrosis and Autophagic Cell Death” Cancer Treatment Review, (2013) S0305-7372(13)00139-4. PMID: 23993415
  9. Izumi K, Mizokami A, Lin WJ, Lai KP and Chang C “Androgen receptor roles in the benign prostate hyperplasia (BPH) development” Am J Pathol, (2013) 182(6): 1942-1949. PMID: 23570837
  10. Ma WL, Jeng LB, Yeh CC and Chang C “Androgen and androgen receptor signals jamming monocyte/macrophage functions in premalignant phase of livers” BioMedicine, xxx: 1-5.  (2012).
  11. Lai JJ, Chang P, Lai KP, Chen L and Chang C “The role of androgen and androgen receptor in skin-related disorders” Arch Dermatol. Res., 304(7), 499-510. (2012). PMID: 22829074
  12. Lin TH, Yeh S and Chang C “Tissue-specific knockout of androgen receptor in mice” Methods Mol. Biol., 776, 275-93. (2011). PMID: 21796532
  13. Niu Y, Chang TM, Yeh S, Ma WL, Wang YZ and Chang C "Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails" Oncogene 24:29(25), 3593-604 (2010). PMID: 20440270
  14. Wang RS, Yeh S, Tzeng CR, and Chang C “Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice” Endocrine Review, (2009): 30(2), 119-32. (2009). PMID: 19176467, PMCID PMC2662628
  15. Yu S, Lai KP, Xie S, Chang HC, Chang C (co-corresponding author) and Yeh S. “The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer” AJA, (2008): 11(1), 39-48, (2008). PMID: 19098932
  16. Ting HJ and Chang C “Actin Associated Proteins Function as Androgen Receptor Coregulators: An Implication of Androgen Receptor's Roles in Skeletal Muscle” JSBMB, 111(3-5), 157-63. (2008) PMID: 18590822
  17. Fujimoto N, Chang C, Nomura M and Matsumoto T "Can we prevent prostate cancer? Rationale and current status of prostate cancer chemoprevention." Urol. Int., 74(4), 289-97. (2005). PMID: 15897691
  18. Miyamoto H, Altuwaijri S, Cai Y, Messing E and Chang C "Inhibition of the Akt, cyclooxygenase-2, and MMP-9 pathways in combination with androgen deprivation therapy: Potential therapeutic approaches for prostate cancer." Mol. Carcinogen, 44(1): 1-10. (2005). PMID: 16044418           
  19. Miyamoto H, messing E and Chang C “Does androgen deprivation therapy improve treatment outcomes in patients with low- and intermediate-risk prostate cancer” Nature Clinical Practice: Oncology, 2: 236-7. (2005). PMID: 16264955
  20. Wang l, Hsu CL and Chang C “Androgen receptor co-repressors: an overview.” Prostate, 63(2), 117-30. (2005). PMID: 15486994
  21. Miyamoto H, Messing E and Chang C “Androgen Deprivation Therapy for Prostate Cancer: Current Status and       Future      Prospects.” Prostate, 61(4), 332-53. (2004). PMID: 15389811
  22. Heinlein CA and Chang C “Androgen receptor in prostate cancer.” Endocrine Reviews, 25, 276-308. (2004). PMID: 15082523
  23. Wang PH and Chang C "Androgens and ovarian cancers” Eur. J. Gynaec. Oncol., 25(2), 157-63. (2004). PMID: 15032272
  24. Miyamoto H, Rahman MM and Chang C “Molecular basis for the antiandrogen withdrawal syndrome” J. Cellular Biochemistry, 91(1), 3-12. (2004). PMID: 14689576
  25. Collins L, Lee H, Chen YT, Yeh S and Chang C "Androgen receptor in spermatogenesis.” Cytogenetic and Genome Research 103(3-4), 289-301. (2003). PMID: 15051951
  26. Lee DK and Chang C “Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication.” J. Clin. Endocrinol. Metab., 88, 4043-954. (2003). PMID: 12970260
  27. Kang HY, Tsai MY, Chang C and Huang KE “Mechanisms and clinical relevance of androgens and androgen receptor action.” Chang Gung Medical J., 26(6), 388-402. (2003). PMID: 12956285
  28. Lee H, and Chang C “Recent advances in the androgen receptor action.” Cellular and Molecular Life Sciences, 60(8), 1613-22. (2003). PMID: 14504652
  29. Lee DK and Chang C “Molecular communication between androgen receptor and general transcription machinery.” JSBMB, 84(1), 41-9. (2003). PMID: 12648523
  30. Heinlein CA, and Chang C “The roles of AR and androgen binding proteins in non-genomic androgen actions.” Mol. Endo., 16(10), 2181-7. (2002). PMID: 12351684           
  31. Heinlein CA and Chang C “Androgen receptor co-regulator: an overview.” Endocrine Review, 23(2), 175-200. (2002). PMID: 11943742
  32. Sampson E, Yeh S, Chang H, Tsai M, Wang X, Ting H-J, and Chang C “Identification and characterization of androgen receptor associated co-regulators in prostate cancer cells.” J. Biological Regulation & Homeostatic Agents, 15(2): 123-9. (2001). PMID: 11501969      
  33. Heinlein CA and Chang C “The role of chaperones in the nuclear translocation and transactivation of steroid receptors.” Endocrine, 14(2), 143-9.(2001). PMID: 1139463
  34. Yeh S, Sampson E, Lee DK, Kim E, Hsu C, Chen Y, Chang HC, Altuwaijri S, Huang K, and Chang C “Functional analysis of N-terminal and Ligand-binding domain of androgen receptor co-activators in prostate cancer.” J. Formosan Medical Association, 99(12): 885-94. (2000). PMID: 11155740         
  35. Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK and Chang C “Differential induction of androgen receptor transcriptional activity by selective androgen receptor co-activators.” Keio J. Medicine, 48(2): 87-92. (1999). PMID: 10405524
  36. Keller ET, Ershler WB, and Chang C “The androgen receptor: a mediator of diverse responses.” Frontiers in Bioscience, 1: d59-71.(1996).PMID: 9159212
  37. Chang C, Saltzman A, Yeh S, Young WJ, Keller E, Lee H-J, Wang C, and Mizokami A “Androgen receptors: an overview.” Critical Reviews in Eukaryotic Gene Expression, 5(2), 97-125.(1995). PMID: 8845584

2.TR4 Reviews


  1. Lin SJ, Zhang YQ, Liu NC, Yang DR, Li G and Chang C “Pathophysiological roles of the TR4 nuclear receptor: lessons learned from mice lacking TR4” Mol Endo (2014) Apr 4:me20131422. PMID: 24702179
  2. Liu S, Lin SJ, Li G, Kim E, Chen YT, Yang D, Tan E, Yong EL, Cai X and Chang C “PPARγ vs TR4 nuclear receptor differential roles in prostate cancer and metabolic diseases” Endocrine Related Cancers 2014, 21(3):R279-R300, PMID:24623743
  3. Ding XF, Yu SC, Chen BD, Lin SJ, Chang C (co-corresponding author) and Li GH. “Recent advances in the study of testicular nuclear receptor 4” J Zhejiang Univ. Sci. B, 14(3): 171-7. (2013). PMID: 23463759. PMCID: PMC3596567
  4. Lee YF, Lee HJ and Chang C “Recent advances in the TR2 and TR4 orphan receptors of nuclear receptor superfamily.”  JSBMB, 81(4-5): 291-308. (2002). PMID: 12361719