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IdStudy TitleThe Question the Study Seeks to Answer
10052Leukemia: A program for monitoring minimal residual disease following treatment of patients with Acute Myeloid Leukemia or High Grade Myelodysplastic Syndrome. Can tests be developed to identify those patients who are at a greater risk for having their disease return?
10139A Geriatric Assessment Intervention for Older Cancer Patients Receiving ChemotherapyDoes information regarding GA and GA-driven interventions improve outcomes in older cancer patients receiving first-line or second-line chemotherapy?
10159Breast Cancer: Phase III study of hormone therapy with or without the study drug (Everolimus) in high risk hormone receptor positive & HER-2 negative breast cancer (S1207)This study compares the use of hormones with a study drug (everolimus) to hormones alone after chemotherapy to see which will keep cancer from returning longer.
10164Rectal Cancer: Phase II/III study of FOLFOX chemotherapy with or without radiation treatment before surgery for locally advanced rectal cancer. (N1048)This study will compare the effects of the standard treatment of chemotherapy and radiation to chemotherapy alone in treating rectal cancer.
10168Breast Cancer: Predictors of Chemotherapy Side Effects in Older AdultsThis study will compare 3 groups of volunteers over the age of 65 years to see how physical function changes over time. The three groups are: people diagnosed with breast cancer who are starting chemotherapy, people diagnosed with breast cancer that are not starting chemotherapy, and healthy (non-Cancer) control subjects.
10172Esophageal Cancer: Study of changes in DNA found in the blood in patients with advanced cancer of the esophagusCan researchers tell if esophagus cancer is responding to chemotherapy treatment using blood tests; as well as if doctors can measure responses with CT scans?
10181Leukemia: Phase I Testing the Addition of Inotuzumab Ozogamicin, to Usual Chemotherapy in Relapsed and Refractory Acute Leukemia The purpose of this study is to test the safety of the experimental drug inotuzumab ozogamicin at different doses to find out what effects, if any, it has on people.
10200Lymphoma: A Phase II Study of Brentuximab Vedotin in Adults Age 60 and Above With Newly Diagnosed Hodgkin Lymphoma (HL)Will the study drug brentuximab vedotin be useful in treating Hodgkin's Lymphoma in adults age 60 or above?
10207Lung Cancer: A Phase I Study of Tetrathiomolybdate in Combination With Carboplatin/Pemetrexed in Metastatic Non-squamous Non-small Cell Lung CancerWill adding the study drug tetrathiomolybdate (TM) to a usual chemotherapy regimen improve the outcome of treatment for patients with non-squamous non-small cell lung cancer?
10212Cancer: Geriatric Assessment and Clinical Outcomes in Older Oncology Patients (SOCARE)We are requesting to be able to use your information to teach others on the best care for adults aged 65 and older with cancer.
10214Bone Marrow Transplant: A Phase III study of Reduced Intensity (RIC) Conditioning and Transplantation of Double Cord Versus Haploidentical in Leukemia & Lymphoma.Which of two transplant regimens has better outcomes?
10216Testicular Cancer (Germ Cell): Genetic Susceptibility and Biomarkers of Platinum-related ToxicitiesAre there genetic markers in the blood that may predict who will experience side effects from chemotherapy?
10218Lymphoma & Leukemia: Collection of specimens and epidemiological and clinical outcomes data in patients with hematological malignancies This is a laboratory study to learn more about what causes blood cancers.
10220Leukemia: Characterization of the bone marrow microenvironment in patients with myelodysplastic syndrome (MDS)This is a laboratory study to learn more about MDS.
10221Leukemia: A Phase I/II Study of Decitabine in Combination with Sequential Rapamycin or Ribavirin in High Risk AML PatientsWill adding decitabine to sequntial rapamycin or ribavirin be beneficial in high risk AML patients?
10253Leukemia: Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia (ALL)What are the affects (good and bad) of the drug blinatumomab on your type of cancer (BCR/ABL negative ALL)? (This drug will be added to what has traditionally been used to treat your specific cancer sub-type.)
10264Lymphoma: Brentuximab vedotin and involved site radiotherapy in newly diagnosed, unfavorable risk Hodgkin lymphoma.Will treatment with a new drug, brentuximab vedotin (BV), combined with adriamycin, vinblastine, and dacarbazine (AVD) chemotherapy followed by radiation improve the ability to cure more patients with Hodgkin Lymphoma?
10271Gastrointestinal (pancreas) Cancer: Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic CancerWill the study drug (Glufosfamide) work as well as Fluorouracil (5-FU), the approved treatment, in treating pancreatic cancer?
10281Rectal Cancer: Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative ManagementIs it better to have extra chemotherapy before surgery or after initial chemo-radiation and surgery?
10282Lung Cancer: "Lung-MAP" S1400 ~ Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IIIB-IV Squamous Cell Lung CancerWill cancer cells respond better to standard treatment or one of the investigational treatments when treatment is chosen based on genes and proteins within the cancer cells called "biomarkers'?
10293Melanoma: Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAF Mutant Melanoma That Cannot Be Removed by SurgeryWill receiving dabrafenib and trametinib with a break in treatment extend the time before your cancer gets worse?
10301Prostate cancer: A laboratory study to isolate and manipulate circulating tumor cells in prostate cancer.Many patients with prostate cancer have a small number of cancer cells circulating in their blood, usually less than 5 in one and one-half (1.5) teaspoons of blood. Will a new lab method be able to separate and collect cancer cells from the blood of prostate cancer patients to be studied in the lab?
10303Bladder Cancer: S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder CancerWill looking at tumor biomarkers using a program called “co-expression extrapolation” or COXEN predict your response to chemotherapy before surgery?
10305Colorectal Cancer: Regorafenib in Adults ≥ 70 Years with Metastatic Colorectal CancerHow does the drug regorafenib effect quality of life and other issues relevant to the elderly when given to adults age 70 or older to treat their colorectal cancer?
10308Bone Marrow Transplant in Multiple Myeloma (MM): Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With Stem Cell Transplant in MM Patients up to Age 65Will the drug combination, lenalidomide, bortezomib and dexamethasone alone OR use of the same drug combination combined with autologous stem cell transplantation (ASCT) work better and have less side effects in newly diagnosed multiple myeloma?
10312Pre-operative Radiation Therapy for Pancreatic CancerIs it safe and practical to perform stereotactic body radiation (SBRT) to pancreatic adenocarcinoma before surgical resection
10334Brain Cancer: Radiation Therapy With Concomitant and Adjuvant Temozolomide or Radiation Therapy With Adjuvant PCV or Temozolomide Alone in Treating Patients With Anaplastic GliomaWill giving temozolomide alone, radiation followed by PCV, or temozolomide together with radiation therapy followed by temozolomide be more effective in treating anaplastic glioma?
10356Lymphoma: A Phase 2 Multicenter Study Evaluating Subjects With Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)Is KTE-C19 safe and effective in treating your lymphoma when administered after a 3 day course of chemotherapy?
10362Lymphoma: A Safety and Efficacy Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin LymphomasWill the antibody (a type of human protein) nivolumab help the body's immune system to work against tumor cells?
10376Leukemia (AML): An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation (IDHENTIFY)Is the study drug AG-221 safe and effective in treating Acute Myeloid Leukemia (AML) when compared to standard therapies?
10379Gynecologic Cancer: Olaparib or Cediranib Maleate and Olaparib Compared With Standard Platinum-Based Chemotherapy in Treating Patients With Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal CancerWill treatment with olaparib by itself or the combination of cediranib and olaparib added to the usual chemotherapy work better in controlling your cancer?
10380Melanoma: High-Dose Recombinant Interferon Alfa-2B or Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by SurgeryWill high dose interferon or MK-3475 work better at stopping your melanoma from coming back after surgery?
10381Pancreatic Cancer: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by SurgeryWill using chemotherapy before surgery for pancreatic cancer work better than giving chemotherapy after surgery?
10382Urinary tract cancer: Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract CancerWill giving chemotherapy before surgery for upper tract urothelial cancer work better to control your cancer?
10385Leukemia (ALL): A Study Evaluating KTE-C19 in Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) (ZUMA-3)Is the experimental product KTE-C19 safe and effective in treating your ALL?
10386Sarcoma: Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic SarcomaHow safe and effective is treatment with MLN0128 when used to treat sarcoma?
10387Melanoma: Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 MelanomaWhat are the good and bad effects of the sequence of immunotherapy followed by BRAF inhibitor therapy if and when the disease becomes resistant, to the sequence of BRAF inhibitor therapy followed by immunotherapy if and when the disease becomes resistant?
10388Leukemia (CLL) & Lymphoma: A Phase 1/2, Open Label, Multicenter Study to Assess the Safety and Tolerability of Durvalumab (anti-PD-L1 Antibody) as Monotherapy and in Combination Therapy in Subjects With Lymphoma or Chronic Lymphocytic LeukemiaHow safe and effective is treatment with Durvalumab in treating lymphoma or CLL?
10389Lymphoma (DLBCL): Study of Brentuximab Vedotin, Rituximab and Dose Attenuated CHP in Elderly Patients with DLBCLWill treatment with brentuximab vedotin, rituximab, and modified chemotherapy with cyclophosphamide, doxorubicin, and prednisone (called R-mini-CHP) minimize the side effects typically experienced by older adults and allow you to be able to complete all cycles of treatment?
10398Pancreatic Cancer: PEGylated Recombinant Human Hyaluronidase in Combo With Nab-Paclitaxel + Gemcitabine VS. Placebo + Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal AdenocarcinomaHow safe and how well tolerated is the study drug PEGPH20 compared with placebo when used in combination with nab-paclitaxel and gemcitabine?
10401Gastric Cancer: Avelumab in First-Line Gastric Cancer (JAVELIN Gastric 100)How safe and effective is treatment with the study drug compared with continuing chemotherapy in patients who receive 12-weeks of initial chemotherapy?
10402Gastric Cancer: Study of TAS-102 or Placebo Plus BSC in Patients With Metastatic Gastric CancerHow safe and effective is treatment with TAS-102 and best supportive care compared to placebo and best supportive care?
10412GU (testicular): EXCAP (Exercise for Cancer Patients) and eHealth exercise intervention for testicular cancer survivorsWill exercise intervention in testicular cancer survivors improve quality of life, depression, anxiety, ability to sleep, energy expenditure, muscular strength, muscle mass, and motivation to exercise?
10415Gynecologic (Cervical) Cancer: Studying the Physical Function and Quality of Life Before and After Surgery in Patients With Stage I Cervical CancerWhich surgical procedure is safest and most effective in removing early stage cervical cancer; while also offering the least amount of side effects and best quality of life outcomes?
10418Upper GI Tract Cancer: 12 week home-based exercise studyWill walking and a progressive resistance program improve symptoms in patients with GI cancers with weight loss and cachexia (weakness of the body, and decreasing muscle mass)?
10428Bladder Cancer: Testing the PD-1 Inhibitor Pembrolizumab as Maintenance Therapy After Initial Chemotherapy in Metastatic Bladder CancerWhat are the good and bad effects of pembrolizumab compared to a placebo in people with metastatic or unresectable bladder cancer that responded after initial chemotherapy?
10429Skin Cancer: Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell CarcinomaWhat are the good or bad effects of REGN2810 in patients with advanced cutaneous squamous cell carcinoma? These effects could be good (for example, shrinking of tumors) or bad (called side effects).
10432Gynecologic Cancer (ovary, fallopian tube, peritoneal): Testing the combination of cediranib and olaparib in comparison to each drug alone or other chemotherapy in recurrent platinum-resistant ovarian cancerWhat are the good or bad effects of using a combination of the investigational agents cediranib and olaparib, compared to using the standard chemotherapy, or cediranib alone, or olaparib alone?
10434Lymphoma/Leukemia (CLL): Evaluate the Efficacy and Safety of TGR-1202 in Patients With Chronic Lymphocytic Leukemia Who Are Intolerant to Prior TherapyHow well tolerated is the investigational drug TGR-1202 in comparison to other similar therapeutics agents?
10436Multiple Cancers: A Phase 1/2, Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced MalignanciesHow safe and tolerable is INCB057643 as a monotherapy for subjects with advanced malignancies; and what doses work the best in the types of cancers studied?
10437Multiple Myeloma: Integrating Touchscreen-based Geriatric Assessment and Frailty Screening for Adults with Multiple Myeloma to Drive Personalized Treatment Decisions What is the feasibility and usability of using a touchscreen-based assessment tool and its impact on treatment decision-making?
10440Evaluation of a tablet-based care coordination system for older cancer patients receiving treatmentIs the use of a tablet-based electronic system helpful to coordinate care in older adults with cancer who are undergoing treatments?
10441Gynecologic (Cervical) Cancer: Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical HysterectomyWhat are the effects of giving additional chemotherapy after the usual chemotherapy and radiation for your cervical cancer?
10442Gynecologic (cervical) cancer: Radiation Therapy With or Without Chemotherapy in Patients With Stage I or Stage II Cervical Cancer Who Previously Underwent SurgeryWill weekly chemotherapy with cisplatin and simultaneous radiation therapy increase the time you live cancer-free compared to radiation alone?
10444Gynecologic (endometrial) cancer: Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial CancerWill radiation therapy in combination with weekly treatment with the chemotherapy drug cisplatin work better than the standard treatment for endometrial cancer? The standard treatment for patients with your type of cancer is radiation therapy alone.
10445Pancreatic Cancer: FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic CancerWhat are the good and bad effects of treatment with ABT-888 (velipaib) and modified FOLFIRI compared to treatment with FOLFIRI alone?
10448Bladder Cancer: Study of Pembrolizumab With or Without Platinum-based Combination Chemotherapy Versus Chemotherapy Alone in Urothelial CarcinomaWhich of 3 treatments will work better at treating your type of cancer?
10449Renal (Kidney) Cancer: Study to Evaluate the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Axitinib Versus Sunitinib Monotherapy in Participants With Renal Cell Carcinoma How safe, tolerable, and effective is the research study drug, Pembrolizumab plus Axitinib compared to Sunitinib alone, for the treatment of patients with advanced or metastatic renal cell carcinoma (RCC) who have not been treated for this condition?
10464Apalutamide (JNJ-56021927) for Advanced Prostate Cancer with Radiation TherapyTo determine if apalutamide plus gonadotropin releasing hormone (GnRH) agonist in subjects with high-risk, localized or locally advanced prostate cancer receiving primary radiation therapy (RT) results in an improvement of metastasis-free survival (MFS) evaluated by blinded independent central review (BICR).
10466Lung or Gastric Cancers: Phase 1b Open-Label Study of PEGPH20 With PembrolizumabHow effective is treatment with the investigational drug PEGPH20 in combination with the immunotherapy antibody, pembrolizumab in stopping the growth or shrinking tumors in patients with non small cell lung cancer (NSCLC) or a type of gastric cancer called adenocarcinoma?
10468Lung Cancer: Afatinib Dimaleate With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage IV or Recurrent, EGFR Mutation Positive Non-small Cell Lung CancerWill the addition of cetuximab to the usual afatinib help to shrink tumors? Will the aide effects be better or worse with the combination?
10469Multiple MyelomaIs there a way to determine which patients are more or less likely to experience disease progression?
10470Multiple Myeloma: Selinexor and Backbone Treatments of Multiple Myeloma Patients (STOMP)Will adding selinexor to other treatment combinations have any effect on your cancer?
10472Ovarian Cancer: Efficacy and Safety Study of Cediranib in Combination With Olaparib in Patients With Recurrent Platinum-Resistant Ovarian Cancer (CONCERTO)How effective and tolerable is treatment with the combination of cediranib and olaparib in patients with ovarian cancer?
10473Abnormal Cervix Cells: CA-IX, p16, Proliferative Markers, and HPV in Diagnosing Cervical Lesions in Patients With Abnormal Cervical CellsCan the presence of human Papillomavirus (HPV) and certain chemical substances (biomarkers) in cervical cells can help identify which women with a cytologic diagnosis of Atypical Glandular Cells (AGC) have a benign condition and which have a pre-cancerous condition or an invasive cancer that requires surgical removal?
10474Bladder Cancer: A Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Urothelial CarcinomaHow well does INCB054828 work in treating metastatic or surgically unresectable Urothelial Carcinoma?
10475Liver Cancer: A Study of BBI608 in Combination With Sorafenib, or BBI503 in Combination With Sorafenib in Adult Patients With Hepatocellular CarcinomaWill adding treatment with study drugs BBI608 or BBI503 to usual treatment with sorafenib help to better treat liver cancer?
10476Biliary Cancer: Efficacy and Safety of INCB054828 in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous TherapyHow well does advanced/metastatic or surgically unresectable Cholangiocarcinoma with or without FGF/FGFR alterations respond to treatment with INCB054828, a selective FGFR inhibitor?
10477Esophageal Cancer: Induction Chemotherapy for Locally Advanced Esophageal CancerWill additional chemotherapy given before standard treatment help to extend the life of esophageal cancer patients?
10478Breast Cancer: Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer (OlympiA)Will adding treatment with olaparib after the usual care of chemotherapy, surgery and radiation reduce the risk of the cancer coming back?
10479GvHD: A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH1)Will taking ruxolitinib in combination with corticosteroids be a safe and effective treatment for people with acute Graft vs Host Disease (GvHD)?
10480Breast Cancer: Exemestane With or Without Entinostat in Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or MetastaticWhat effects (good or bad) will the study drug entinostat have on you and your cancer when given together with standard hormonal treatment called exemestane?
10481Breast cancer: Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast CancerWhat are the effects (good or bad) of adding a chemotherapy drug called carboplatin to the usual chemotherapy drugs given after surgery?
10482Brain Cancer: Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in GlioblastomaWill adding treatment with ICT-107 to the usual treatment for glioblastoma (surgery, radiation and chemotherapy) help to prevent brain tumors from coming back better than standard treatment alone?
10485Energy Therapy (Reiki) or Massage to Reduce FatigueHow effective is Reiki Therapy or Massage in reducing fatigue in patients receiving hormonal therapy for breast or prostate cancer?
10492Vitamin D and non-Hodgkin lymphomaCan taking Vitamin D improve the survival of patients with lymphoma?
10493Lymphoma (Bone Marrow Transplant): Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell LymphomaWhat are the good and/or bad effects of using an oral medication, ibrutinib, along with the autologous hematopoietic stem cell transplantation (AutoHCT) versus AutoHCT alone?
10494Chronic Graft Versus Host Disease (Bone Marrow Transplant): Ibrutinib in Combination With Corticosteroids Versus Placebo in Combination With Corticosteroids in Subjects With New Onset Chronic Graft Versus Host Disease (cGVHD) (iNTEGRATE)What are the effects of combining two drugs: ibrutinib and prednisone compared to placebo (sometimes called a “sugar pill”) and prednisone in patients with chronic Graft Versus Host Disease (cGVHD)?