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IdStudy TitleThe Question the Study Seeks to Answer
10052Leukemia: A program for monitoring minimal residual disease following treatment of patients with Acute Myeloid Leukemia or High Grade Myelodysplastic Syndrome. Can tests be developed to identify those patients who are at a greater risk for having their disease return?
10159Breast Cancer: Phase III study of hormone therapy with or without the study drug (Everolimus) in high risk hormone receptor positive & HER-2 negative breast cancer (S1207)This study compares the use of hormones with a study drug (everolimus) to hormones alone after chemotherapy to see which will keep cancer from returning longer.
10164Rectal Cancer: Phase II/III study of FOLFOX chemotherapy with or without radiation treatment before surgery for locally advanced rectal cancer. (N1048)This study will compare the effects of the standard treatment of chemotherapy and radiation to chemotherapy alone in treating rectal cancer.
10172Esophageal Cancer: Study of changes in DNA found in the blood in patients with advanced cancer of the esophagusCan researchers tell if esophagus cancer is responding to chemotherapy treatment using blood tests; as well as if doctors can measure responses with CT scans?
10181Leukemia: Phase I Testing the Addition of Inotuzumab Ozogamicin, to Usual Chemotherapy in Relapsed and Refractory Acute Leukemia The purpose of this study is to test the safety of the experimental drug inotuzumab ozogamicin at different doses to find out what effects, if any, it has on people.
10200Lymphoma: A Phase II Study of Brentuximab Vedotin in Adults Age 60 and Above With Newly Diagnosed Hodgkin Lymphoma (HL)Will the study drug brentuximab vedotin be useful in treating Hodgkin's Lymphoma in adults age 60 or above?
10218Lymphoma & Leukemia: Collection of specimens and epidemiological and clinical outcomes data in patients with hematological malignancies This is a laboratory study to learn more about what causes blood cancers.
10220Leukemia: Characterization of the bone marrow microenvironment in patients with myelodysplastic syndrome (MDS)This is a laboratory study to learn more about MDS.
10221Leukemia: A Phase I/II Study of Decitabine in Combination with Sequential Rapamycin or Ribavirin in High Risk AML PatientsWill adding decitabine to sequntial rapamycin or ribavirin be beneficial in high risk AML patients?
10264Lymphoma: Brentuximab vedotin and involved site radiotherapy in newly diagnosed, unfavorable risk Hodgkin lymphoma.Will treatment with a new drug, brentuximab vedotin (BV), combined with adriamycin, vinblastine, and dacarbazine (AVD) chemotherapy followed by radiation improve the ability to cure more patients with Hodgkin Lymphoma?
10271Gastrointestinal (pancreas) Cancer: Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic CancerWill the study drug (Glufosfamide) work as well as Fluorouracil (5-FU), the approved treatment, in treating pancreatic cancer?
10281Rectal Cancer: Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative ManagementIs it better to have extra chemotherapy before surgery or after initial chemo-radiation and surgery?
10282Lung Cancer: "Lung-MAP" S1400 ~ Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IIIB-IV Squamous Cell Lung CancerWill cancer cells respond better to standard treatment or one of the investigational treatments when treatment is chosen based on genes and proteins within the cancer cells called "biomarkers'?
10301Prostate cancer: A laboratory study to isolate and manipulate circulating tumor cells in prostate cancer.Many patients with prostate cancer have a small number of cancer cells circulating in their blood, usually less than 5 in one and one-half (1.5) teaspoons of blood. Will a new lab method be able to separate and collect cancer cells from the blood of prostate cancer patients to be studied in the lab?
10305Colorectal Cancer: Regorafenib in Adults ≥ 70 Years with Metastatic Colorectal CancerHow does the drug regorafenib effect quality of life and other issues relevant to the elderly when given to adults age 70 or older to treat their colorectal cancer?
10308Bone Marrow Transplant in Multiple Myeloma (MM): Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With Stem Cell Transplant in MM Patients up to Age 65Will the drug combination, lenalidomide, bortezomib and dexamethasone alone OR use of the same drug combination combined with autologous stem cell transplantation (ASCT) work better and have less side effects in newly diagnosed multiple myeloma?
10330Brain Cancer: Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma MultiformeIs temozolomide more effective in treating glioblastoma multiforme with or without the addition of veliparib?
10334Brain Cancer: Radiation Therapy With Concomitant and Adjuvant Temozolomide or Radiation Therapy With Adjuvant PCV or Temozolomide Alone in Treating Patients With Anaplastic GliomaWill giving temozolomide alone, radiation followed by PCV, or temozolomide together with radiation therapy followed by temozolomide be more effective in treating anaplastic glioma?
10356Lymphoma: A Phase 2 Multicenter Study Evaluating Subjects With Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)Is KTE-C19 safe and effective in treating your lymphoma when administered after a 3 day course of chemotherapy?
10376Leukemia (AML): An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation (IDHENTIFY)Is the study drug AG-221 safe and effective in treating Acute Myeloid Leukemia (AML) when compared to standard therapies?
10382Urinary tract cancer: Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract CancerWill giving chemotherapy before surgery for upper tract urothelial cancer work better to control your cancer?
10385Leukemia (ALL): A Study Evaluating KTE-C19 in Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) (ZUMA-3)Is the experimental product KTE-C19 safe and effective in treating your ALL?
10388Leukemia (CLL) & Lymphoma: A Phase 1/2, Open Label, Multicenter Study to Assess the Safety and Tolerability of Durvalumab (anti-PD-L1 Antibody) as Monotherapy and in Combination Therapy in Subjects With Lymphoma or Chronic Lymphocytic LeukemiaHow safe and effective is treatment with Durvalumab in treating lymphoma or CLL?
10398Pancreatic Cancer: PEGylated Recombinant Human Hyaluronidase in Combo With Nab-Paclitaxel + Gemcitabine VS. Placebo + Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal AdenocarcinomaHow safe and how well tolerated is the study drug PEGPH20 compared with placebo when used in combination with nab-paclitaxel and gemcitabine?
10412GU (testicular): EXCAP (Exercise for Cancer Patients) and eHealth exercise intervention for testicular cancer survivorsWill exercise intervention in testicular cancer survivors improve quality of life, depression, anxiety, ability to sleep, energy expenditure, muscular strength, muscle mass, and motivation to exercise?
10428Bladder Cancer: Testing the PD-1 Inhibitor Pembrolizumab as Maintenance Therapy After Initial Chemotherapy in Metastatic Bladder CancerWhat are the good and bad effects of pembrolizumab compared to a placebo in people with metastatic or unresectable bladder cancer that responded after initial chemotherapy?
10429Skin Cancer: Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell CarcinomaWhat are the good or bad effects of REGN2810 in patients with advanced cutaneous squamous cell carcinoma? These effects could be good (for example, shrinking of tumors) or bad (called side effects).
10433Gynecologic Cancer (Ovary, Peritoneal): Trametinib in Treating Patients With Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity CancerWhich will work better to treat your low-grade serious ovarian or peritoneal cancer: trametinib OR one of the standard treatments available that your doctor will choose for you (either letrozole, tamoxifen, paclitaxel, pegylated liposomal doxorubicin [PLD], or topotecan)?
10437Multiple Myeloma: Integrating Touchscreen-based Geriatric Assessment and Frailty Screening for Adults with Multiple Myeloma to Drive Personalized Treatment Decisions What is the feasibility and usability of using a touchscreen-based assessment tool and its impact on treatment decision-making?
10440Evaluation of a tablet-based care coordination system for older cancer patients receiving treatmentIs the use of a tablet-based electronic system helpful to coordinate care in older adults with cancer who are undergoing treatments?
10441Gynecologic (Cervical) Cancer: Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical HysterectomyWhat are the effects of giving additional chemotherapy after the usual chemotherapy and radiation for your cervical cancer?
10442Gynecologic (cervical) cancer: Radiation Therapy With or Without Chemotherapy in Patients With Stage I or Stage II Cervical Cancer Who Previously Underwent SurgeryWill weekly chemotherapy with cisplatin and simultaneous radiation therapy increase the time you live cancer-free compared to radiation alone?
10444Gynecologic (endometrial) cancer: Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial CancerWill radiation therapy in combination with weekly treatment with the chemotherapy drug cisplatin work better than the standard treatment for endometrial cancer? The standard treatment for patients with your type of cancer is radiation therapy alone.
10448Bladder Cancer: Study of Pembrolizumab With or Without Platinum-based Combination Chemotherapy Versus Chemotherapy Alone in Urothelial CarcinomaWhich of 3 treatments will work better at treating your type of cancer?
10466Lung or Gastric Cancers: Phase 1b Open-Label Study of PEGPH20 With PembrolizumabHow effective is treatment with the investigational drug PEGPH20 in combination with the immunotherapy antibody, pembrolizumab in stopping the growth or shrinking tumors in patients with non small cell lung cancer (NSCLC) or a type of gastric cancer called adenocarcinoma?
10468Lung Cancer: Afatinib Dimaleate With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage IV or Recurrent, EGFR Mutation Positive Non-small Cell Lung CancerWill the addition of cetuximab to the usual afatinib help to shrink tumors? Will the aide effects be better or worse with the combination?
10469Multiple MyelomaIs there a way to determine which patients are more or less likely to experience disease progression?
10470Multiple Myeloma: Selinexor and Backbone Treatments of Multiple Myeloma Patients (STOMP)Will adding selinexor to other treatment combinations have any effect on your cancer?
10472Ovarian Cancer: Efficacy and Safety Study of Cediranib in Combination With Olaparib in Patients With Recurrent Platinum-Resistant Ovarian Cancer (CONCERTO)How effective and tolerable is treatment with the combination of cediranib and olaparib in patients with ovarian cancer?
10473Abnormal Cervix Cells: CA-IX, p16, Proliferative Markers, and HPV in Diagnosing Cervical Lesions in Patients With Abnormal Cervical CellsCan the presence of human Papillomavirus (HPV) and certain chemical substances (biomarkers) in cervical cells can help identify which women with a cytologic diagnosis of Atypical Glandular Cells (AGC) have a benign condition and which have a pre-cancerous condition or an invasive cancer that requires surgical removal?
10474Bladder Cancer: A Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Urothelial CarcinomaHow well does INCB054828 work in treating metastatic or surgically unresectable Urothelial Carcinoma?
10476Biliary Cancer: Efficacy and Safety of INCB054828 in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous TherapyHow well does advanced/metastatic or surgically unresectable Cholangiocarcinoma with or without FGF/FGFR alterations respond to treatment with INCB054828, a selective FGFR inhibitor?
10477Esophageal Cancer: Induction Chemotherapy for Locally Advanced Esophageal CancerWill additional chemotherapy given before standard treatment help to extend the life of esophageal cancer patients?
10479GvHD: A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH1)Will taking ruxolitinib in combination with corticosteroids be a safe and effective treatment for people with acute Graft vs Host Disease (GvHD)?
10481Breast cancer: Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast CancerWhat are the effects (good or bad) of adding a chemotherapy drug called carboplatin to the usual chemotherapy drugs given after surgery?
10482Brain Cancer: Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in GlioblastomaWill adding treatment with ICT-107 to the usual treatment for glioblastoma (surgery, radiation and chemotherapy) help to prevent brain tumors from coming back better than standard treatment alone?
10493Lymphoma (Bone Marrow Transplant): Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell LymphomaWhat are the good and/or bad effects of using an oral medication, ibrutinib, along with the autologous hematopoietic stem cell transplantation (AutoHCT) versus AutoHCT alone?
10494Chronic Graft Versus Host Disease (Bone Marrow Transplant): Ibrutinib in Combination With Corticosteroids Versus Placebo in Combination With Corticosteroids in Subjects With New Onset Chronic Graft Versus Host Disease (cGVHD) (iNTEGRATE)What are the effects of combining two drugs: ibrutinib and prednisone compared to placebo (sometimes called a “sugar pill”) and prednisone in patients with chronic Graft Versus Host Disease (cGVHD)?
10495Cancer (Geriatric): Cognitive Rehabilitation For At-Risk Older Cancer Patients Receiving Chemotherapy: A Pilot Study Evaluating Feasibility And ImpactDoes a dual-approach cognitive rehabilitation intervention help reduce loss of independence and chemotherapy-related cognitive impairment?
10497Pancreatic Cancer: Sapanisertib in Treating Patients With Metastatic or Refractory Pancreatic Neuroendocrine Tumor That Cannot Be Removed by SurgeryWhat are the good and/or bad effects of the study drug MLN0128 (TAK-228) in patients with advanced pancreatic neuroendocrine tumors (PNET) that are no longer responding to rapalog therapy?
10498Pancreatic Cancer: A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma (CanStem111P)Will patients with pancreatic cancer have a longer cancer free survival when receiving treatment with nab-Paclitaxel and Gemcitabine with the study drug, BBI-608, versus treatment with nab-Paclitaxel and Gemcitabine alone?
10504Prostate Cancer: A Study of Rucaparib Verses Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency (TRITON3)What is the safety and anti-tumor effect of rucaparib with that of comparator treatment in patients with prostate cancer, and who have mutations in BRCA or ATM?
10505Prostate Cancer: A Study of Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency (TRITON2)Is rucaparib is a good treatment option in patients with prostate cancer, and who have mutations in BRCA, ATM, or other DNA-repair genes that are linked with benefit from treatment with a PARP inhibitor?
10506Kidney Cancer: A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy (IMmotion010)What are the good or bad effects of atezolizumab versus placebo on you and your Renal Cell Carcinoma (RCC)?
10507Prostate Cancer: ODM-201 in Addition to Standard ADT and Docetaxel in Metastatic Castration Sensitive Prostate Cancer (ARASENS)Is Darolutamide (ODM-201) effective at keeping your cancer under control when given in addition to standard treatment which includes androgen deprivation therapy (ADT) and docetaxel chemotherapy?
10509Ovarian Cancer: A Study of Niraparib Maintenance Treatment in Patients With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based ChemotherapyCan niraparib help delay worsening of cancer among patients who had a good response to previous treatment with a platinum-type chemotherapy drug?
10512Head and Neck Cancer: Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone SurgeryDo the changes in a gene called TP53 influence the response to radiation therapy alone or radiation therapy in combination with cisplatin chemotherapy?
10513Head and Neck Cancer: Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412)What is the safety, tolerability and anti-tumor activity of the research study drug pembrolizumab (MK-3475) in combination with chemoradiation (CRT) to placebo in combination with CRT in subjects with locally advanced head and neck squamous cell carcinoma?
10514Leukemia (AMS or MDS): A Biomarker-Directed Phase 2 Trial of SY-1425 in Patients With Acute Myeloid Leukemia or Myelodysplastic SyndromeCan the investigational drug, SY-1425 (tamibarotene) work in treating AML and MDS in patients with a certain biomarker in their blood?
10515Multiple Myeloma or Lymphoma: Study of CLR 131 in Relapsed or Refractory Select B-Cell MalignanciesIs the study drug, CLR 131, effective for the treatment of multiple myeloma or certain lymphomas?
10516Lymphoma (FL): Obinutuzumab With or Without PI3K-delta Inhibitor TGR-1202, Lenalidomide, or Combination Chemotherapy in Treating Patients With Relapsed or Refractory Grade I-IIIa Follicular LymphomaWhat are the good and bad effects of using TGR-1202 and lenalidomide in combination with the antibody, obinutuzumab?
10517Lymphoma (iNHL): A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects With Relapsed/Refractory Indolent Non-Hodgkin Lymphoma (ZUMA-5)Is the experimental product, KTE-C19, when administered after you receive a 3 day course of chemotherapy, safe and effective in treating your disease?
10519Lymphoma: A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral eFT508 in Subjects With Hematological MalignanciesWill the new study drug, eFT508, be useful as a cancer treatment in the future?
10520Lymphoma/Leukemia (CLL): A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic LeukemiaHow safe is the investigational intervention of ibrutinib and obinutuzumab and what is the best order of administration of these two drugs?
10521Lymphoma (iNHL): A Study to Evaluate the Effect of Vitamin D on PFS in Indolent Non-Hodgkin's Lymphoma (ILyAD)Can modification of vitamin D levels in the blood, through supplementation, improve outcomes in patients with indolent lymphoma treated with rituximab?
10525Lymphoma (DLBCL): Impact of CD34+ Cell Dose on Progression-free Survival Following High-Dose Therapy and Autologous Stem Cell Transplantation for Relapsed and Refractory Diffuse Large B-cell Lymphoma (DLBCL)What is the impact of the stem cell dose (number of cells) on the outcome after autologous transplant?
10526Squamous Cell Carcinoma of the Head and Neck Cancer: PD 0332991 and Cetuximab in Patients With Incurable SCCHNWhat is the maximum tolerated dose of palbociclib when given in combination with cetuximab? What are the effects of this drug combination and how effective is it?
10527Study to identify the best type of anesthesia (medicine that puts you to sleep) during cancer surgeryThis study looks at two different kinds of anesthesia (medicine that puts you to sleep during surgery) to see if one is better than the other during cancer surgery.
10528Breast Cancer: Platinum Based Chemotherapy or Capecitabine in Treating Patients With Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant ChemotherapyWhat are the good and bad effects of getting more treatment with capecitabine (i.e. one of the usual approaches) compared to getting more treatment with a platinum-based chemotherapy (cisplatin or carboplatin) after surgery?
10529Myelodysplastic Syndromes: A Safety and Efficacy Study of Pracinostat and Azacitidine in Patients With High Risk Myelodysplastic SyndromesHow does the investigational drug pracinostat work and how safe is it when given with azacitidine?
10531Biliary Cancer: Phase 1b PEGPH20 with Cis & Gem; PEGPH20 with Atezolizumab, Cis & Gem; and compared with Cis & Gem alone in HA-High Subjects with Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder AdenocarcinomaWhat is the safety, tolerability and efficacy of PEGPH20 with Cis and Gem and PEGPH20 with Cis and Gem and Atezolizumab in comparison to Cis and Gem alone?
10542Bladder Cancer: A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer (EV-201)How does enfortumab vedotin affect patients with urothelial cancer?
10543Lung Cancer: VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer (CLASSICAL-Lung)What is the safety and tolerability of VX15/2503 when given in combination with avelumab and what dose level of VX15/2503 to be given with 10 mg/kg of avelumab every 2 weeks?
10544Colon Cancer: Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch RepairWhat are the good and bad effects of using the drug atezolizumab along with the usual chemotherapy, FOLFOX, compared to the usual chemotherapy, FOLFOX, alone?
10545(Myelofibrosis): Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis Previously Treated With RuxolitinibWhat dose of the study drug, pacritinib, is safest and works best for patients with myelofibrosis?
10546Lymphoma (PTCL): A Study of Duvelisib in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL)What are the good or bad effects of 3 different doses of duvelisib on you and your relapsed or refractory PTCL and which dose level is best at treating PTCL?
10547Head and Neck Cancer: ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive TreatmentHow safe and what are the effects of ACTOplus met® XR on people and their risk of cancers of the head or neck?
10548Bone Marrow Transplant (Hodgkin Lymphoma (HL)): Pembrolizumab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin LymphomaWhat is the Complete Response (CR) rate prior to Autologous Hematopoietic Stem Cell Transplant (AHSCT) with the combination of pembrolizumab and ICE salvage chemotherapy for relapsed/refractory Hodgkin lymphoma?
10551Lymphoma/Leukemia (CLL/SLL): Venetoclax in Combination With Ublituximab and Umbralisib (TGR-1202) in Patients With Relapsed or Refractory CLL/SLLWhat is the safety and efficacy of a new investigational combination of drugs venetoclax in combination with Ublituximab and Umbralisib (TGR-1202)) that have not been tried before?
10552Lung Cancer (NSCLC): Expanded Access For Lorlatinib For Patients With Non Small Cell Lung Cancer Carrying an ALK or ROS1 RearrangementThere is no research question. This is an expanded access program.
10553Lung Cancer (NSCLC): A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLCWhat are the effects of the study drugs, lorlatinib when given alone to crizotinib given alone and which is better for treating ALK-positive NSCLC?
10554Breast Cancer: HOMING Study: Harvest of Circulating Tumor Cells (CTCs) from Patients with Metastatic Breast Cancer (MBC) using the Parsortix PC1 System Can the new Parsortix PC1 system capture and harvest CTCs (circulating tumor cells) from blood and show that the cells can be used for different types of subsequent evaluations including cancer related gene expression evaluations?
10555Leukemia (AML & MDS): Azacitidine With or Without Nivolumab or Midostaurin, or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic SyndromeWhat are the good and bad effects of using different new treatment options (azacitidine & nivolumab or azacitidine & midostaurin) to one of the current standard treatment options (azacitidine alone) given for patients with AML or MDS who cannot tolerate or do not want to get intensive chemotherapy?
10556Multiple Cancers: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)Will matching certain drugs or drug combinations in adults whose tumors have specific gene abnormalities; effectively treat their cancer, regardless of their cancer type?
10557Melanoma: Ipilimumab With or Without Nivolumab in Treating Patients With Melanoma That Is Stage IV or Stage III and Cannot Be Removed by SurgeryWhat are the good and bad effects of using ipilimumab in combination with nivolumab compared to the usual approach of using ipilimumab alone?
10558Lung Cancer (NSCLC): A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid TumorsHow safe is and what is the anti-cancer effectiveness of the investigational study drug, PF-06801591?
10559Multiple Myeloma: A Study of Denosumab in Multiple Myeloma Patients With Renal InsufficiencyHow safe is and what is the tolerability of denosumab in newly diagnosed or relapsed multiple myeloma patients?
10560Gastric & Gastroesophageal Cancer: A Study of FPA144 Combined With Modified FOLFOX6 in Gastric/Gastroesophageal Cancer (FIGHT)How safe and what is the tolerability of the new investigational compound, called FPA144, in combination with chemotherapy (a combination of 5-fluorouracil, oxaliplatin, and leucovorin called mFOLFOX6), for the treatment of gastric and/or gastroesophageal cancer and other solid tumors?
10562Multiple Cancers: Nivolumab and Ipilimumab in Treating Patients With Rare TumorsWhat are the good and bad effects of the combination of study drugs called ipilimumab and nivolumab in treating rare cancers and cancers of unknown primary origin?
10563Leukemia (AML): Ivosidenib Expanded Access Program in Relapsed/Refractory AML With an IDH1 MutationThere is no research question. This is an expanded access program.
10564Multiple Cancers: A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic MalignanciesWhat is the safety and tolerability of INCAGN01949, how is INCAGN01949 broken down and eliminated from the body, how does INCAGN01949 act in and on the body, and what are the effects that INCAGN01949 have on your cancer when combined with nivolumab and/or ipilimumab?
10570Multiple Myeloma: Effects of Hyperbaric Oxygen (HBO) on Blood Count Recovery After Autologous Hematopoietic Stem Cell (HSPC) Transplant for Multiple MyelomaWhat are the effects of Hyperbaric Oxygen (HBO) therapy on the engraftment process and patient recovery following transplant, on hospital stay, blood and platelet transfusion needs, use of growth factors, and incidence and severity of mucositis, and on multiple myeloma disease control?
10571Bladder Cancer: Different Strains of BCG With or Without Vaccine in High Grade Non- Muscle Invasive Bladder CancerWhat are the good and bad effects of using the Tokyo-172 version of BCG with the currently used BCG LIVE (TICE® BCG) version on people with bladder cancer receiving BCG in the bladder and what are the good and bad effects of adding a BCG vaccination (given under the skin) in addition to placing BCG in only the bladder?
10572Colorectal Cancer: Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal CancerIs adding the experimental drug, atezolizumab (MPDL3280A), to a usual treatment or giving the experimental drug alone better than the usual treatment alone and what are the good and bad effects of atezolizumab when added to the usual treatment and given alone?
10578Hairy Cell Leukemia: Quality of Life and Clinical Outcomes of Hairy Cell Leukemia Patients: A Longitudinal StudyWhat is the quality of life of patients with hairy cell leukemia?
10579Gastric or Gastroesophageal Junction: Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)What is the safety, efficacy, and tolerablity of the research study drug pembrolizumab (MK-3475) in combination with cisplatin and capecitabine or cisplatin and 5-fluorouracil (5-FU) or FLOT (docetaxel, oxaliplatin, 5-FU and leucovorin)?
10580Leukemia (AML & MDS): Connect® MDS and AML: The Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease RegistryWhat are the patterns of diagnosis, treatment and outcomes including disease progression and survival; what are the patterns for quality of life in patients newly diagnosed with Lower-Risk MDS, Higher-Risk MDS, ICUS or AML and what effect does different treatments have on a patient's disease and on their quality of life?
10581Ovarian Cancer: CANscriptTM Clinical Outcomes in a Real-World Setting (ANCERS)-2Are the CANscript™ (a sensitivity assay, which is a different way to test if your cancer is sensitive to the drugs or drug combination) test results helpful in selecting which treatment you should receive?
10585Ovarian Cancer: Phase 2, A Study of Niraparib Combined With Bevacizumab Maintenance Treatment in Patients With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based ChemotherapyDoes niraparib, in combination with with bevacizumab, help delay the worsening of cancer in people who had a good response to earlier treatment in with a platinum-type chemotherapy drug?
10586Ovarian Cancer: Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal CancerWhat are good and bad effects of adding atezolizumab to the usual chemotherapy (liposomal doxorubicin) and to the usual chemotherapy with bevacizumab?
10587Lymphoma (Diffuse Large B Cell): A Study Evaluating the Efficacy of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma (DLBCL) (ZUMA-7)Is the experimental treatment, axi-cel, safety and effective in treating your lymphoma, compared to standard of care therapy, which includes platinum-based combination therapy with rituximab, followed by high dose therapy and autologus stem cell transplant (ASCT)?
10588Lymphoma (Follicular Lymphoma (FL)): Pilot Study to Evaluate Circulating Tumor DNA in Follicular LymphomaCan liquid biopsies be part of routine care for patients with follicular lymphoma?
10589Sarcoma: Immunotherapy + Radiation in Resectable Soft Tissue SarcomaWhat are the side effects of adding two medications, ipilimumab and nivolumab, to radiation for your sarcoma?
10590Lymphoma/Leukemia (CLL/SLL): A Study Comparing BGB-3111 With Bendamustine Plus Rituximab in Patients With Previously Untreated CLL or SLLWhat are the good and bad effects of the experimental drug BGB-3111, versus a known standard treatment called bendamustine plus rituximab (B+R) on you and your chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)?
10599Ovarian Cancer: Utilizing Human Ovarian, Fallopian and Primary Peritoneal Cancer Patient Tissue to Identify Novel TherapiesWhat is the natural history of ovarian, fallopian and peritoneal cancer, the causes, diagnosis and treatments?
10600Lymphoma (DLBCL): A Study Comparing the Efficacy & Safety of Polatuzumab Vedotin w/ Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone vs Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, & Prednisone in Diffuse Large B-Cell Lymphoma (POLARIX)What are the good and bad effects of polatuzumab vedotin in combination with four other drugs, rituximab (R) (also known as Rituxan® and MabThera®), cyclophosphamide (C), doxorubicin (H), and prednisone (P) (when given together, referred to as R-CHP) compared with vincristine (O) in combination with R-CHP (referred to as R-CHOP) on you and your lymphoma and which treatment is better?
10601Colorectal Cancer: S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by SurgeryWhat are the good and bad effects of using a combination of antibodies called trastuzumab and pertuzumab compared to using the usual chemotherapy of cetuximab and irinotecan?
10602Lung Cancer: Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung CancerWhat are the good and bad effects of using nivolumab (OPDIVO®) along with the usual chemotherapy regimen of cisplatin/carboplatin and etoposide compared to using the usual chemotherapy approach alone?