Health Research

Randomized Mexiletine Trial for Myotonic Dystrophy Type-1

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Basic Study Information

Will the drug mexiletine (150mg three times daily) improve walking, myotonia (delayed grip release), strength, pain, functionality, cardiac conduction irregularities, or quality of life in participants after 3 and 6 months of treatment?
The study involves three visits with overnight stays at the University of Rochester. Travel costs may be reimbursed up to $500 per visit. Study procedures include taking study drug (mexiletine or placebo), a physical exam, collection of blood and urine samples, muscle testing, questionnaires, EKGs, DEXA scans, and 24-hour Holter monitoring. There is no cost to you to participate, and you will be provided an honorarium after completing each visit.
University of Rochester Medical Center

Lead Researcher (Principal Investigator)

Richard Moxley, MD

Study Contact Information

Elizabeth Luebbe
(585) 275-7867

Want to participate in this study?

Your Information
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Do you have difficulty relaxing your fingers after making a tight fist (grip myotonia)?

Are you able to walk for 6 minutes without difficulty?

Have you had a DNA/genetic test (blood test) for myotonic dystrophy?



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Additional Study Information


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