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AHR Conference 2016

PROGRAM

Wednesday, August 3, 2016


Memorial Art Gallery (MAG),
500 University Avenue, Rochester, NY 14607
 

4:00 pm - 6:00 pm
Complimentary Memorial Art Gallery Exhibits Access (Free Parking)

4:00 pm - 7:30 pm
Registration Desk Open
Memorial Art Gallery Vaden Brul Pavilion

6:00 pm
Welcome & Introduction of Keynote Lecture (Memorial Art Gallery Auditorium)
Paige Lawrence, University of Rochester (USA)
Alvaro Puga, University of Cincinnati (USA)

Dioxin and the aryl hydrocarbon receptor: Synergy of discovery
Linda Birnbaum, Director, National Institute of Environmental Health Science, National Institutes of Health (USA)

7:00 pm - 9:00 pm
Cocktail Reception
Open Bar, Hors d’oeuvres, Sweets, Coffee/Tea
Memorial Art Gallery Vaden Brul Pavilion

Thursday, August 4, 2016

University of Rochester School of Medicine and Dentistry (SMD)
601 Elmwood Avenue, Rochester, NY, 14642

All oral presentations are held in the Class of ’62 Auditorium

7:15 am 
Shuttle service from the Strathallan to the University of Rochester
A complementary shuttle bus will leave the hotel at 7:15 and at 7:45
Speakers are encouraged to arrive early to preload presentations no later than 7:45 AM

7:00 am
Conference registration opens (Location: Flaum Foyer)

8:00 am
Meeting Opening (Location: Class of ’62 Auditorium)
Paige Lawrence

Session One: Canonical and non-canonical AHR signaling pathways
Chair: Alvaro Puga, University of Cincinnati (USA)

8:15 am
Diversity as opportunity: Insights from 600 million years of AHR evolution 
Mark Hahn, Woods Hole Oceanographic Institute (USA)

8:45 am
Neanderthal vs. human: Evolutionary evidence for the segregation of exogenous and endogenous AHR ligand sensitivity
Gary Perdew, Pennsylvania State University (USA)

9:15 am
New insights into non-canonical AHR signaling
Cornelis Elferink, University of Texas Medical Branch Galveston (USA)

9:45 am
Break (Location: Flaum Atrium)
Beverages & light snacks

Session Two: The ligands: Good, bad & ugly
Chair: Miroslav Machala, Masaryk University (Czech Republic)

10:15 am
A fistful of ligands: AHR ligand promiscuity and response
Michael Denison, University of California Davis (USA)

10:45 am
Indolo[3,2-b]carbazoles as endogenous AHR ligands - Formation, metabolism and biological functions
Emma Wincent, Institute of Environmental Medicine (Sweden)

11:15 am
Beyond the aryl hydrocarbon receptor - Metabolic reprogramming in TCDD-elicited hepatotoxicity
Tim Zacharewski, Michigan State University (USA)

11:45 am
Lunch and Poster Session I (Location: Flaum Atrium, LeChase Assembly Hall)

Session Three: AHR activation by microorganisms
Chair: Gary Perdew, Pennsylvania State University (USA)

1:15 pm
AHR as a master regulator of the host-gut microbiota communication network
Andrew Patterson, Pennsylvania State University (USA)

1:45 pm
Endogenous and bacterially derived AHR ligands influence inflammation and disease outcome
Francesca Fallarino, University of Perugia (Italy)

2:15 pm
AHR activation by probiotics inhibits colitis
Atsushio Nakao, University of Yamanashi (Japan)

2:45 pm
Break (Location: Flaum Atrium)
Beverages, light snacks, and Ice Cream Truck

Session Four: Regulation of cellular differentiation
Chair: Chiharu Tohyama, University of Tsukuba (Japan)

3:15 pm
AHR-controlled interleukin 22 protects intestinal stem cells from genotoxic stress
Andreas Diefenbach, University of Freiburg (Germany)

3:45 pm
AHR regulates cellular pluripotency and differentiation through Alu-regulated stemness genes
Pedro Fernandez-Salguero, Universidad de Extremadura (Spain)

Session Five: Emerging science I
Chair: Cornelia Dietrich, Institute of Toxicology, University Medical Center, Mainz, Germany

4:15 pm
ARNT isoform-specific regulation of AHR signaling
Casey Wright, The University of Texas at Austin (USA)

4:28 pm
Repression of the AHR is required to maintain mitotic progression and prevent loss of pluripotency of embryonic stem cells
Chia-I Ko, University of Cincinnati College of Medicine (USA)

4:40 pm
NAD+ depletion by PARP activation mediates thymus involution and hepatic steatosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo
Siliva Diani-Moore, Weill Cornell Medicine (USA)

4:52 pm
Association of an orphan nuclear receptor NR2E3 with liver cancer via lysine (K)-specific demethylase 1-dependent repression of aryl hydrocarbon receptor expression
Kyounghyun Kim, University of Cincinnati College of Medicine (USA)

5:05 pm
AHR control of oral squamous cell carcinoma migration and tumorigenesis
David Sherr, Boston University School of Public Health (USA)

5:20 pm
Moderated Discussion
Are the physiological effects of AHR activation the basis of the toxicity of some of its ligands?
Discussion Leader: Robert Barouki, Paris Descartes University (France)

6:30 pm
Adjourn for the day

6:00 pm - 7:30 pm
Shuttle service from University of Rochester to the Strathallan
A bus will pick up conference attendees outside the Flaum Atrium exit at about 6:00, 6:30, 7:00 PM

Friday, August 5, 2016

University of Rochester School of Medicine and Dentistry (SMD)
601 Elmwood Avenue, Rochester, NY, 14642

All oral presentations are held in the Class of ’62 Auditorium

7:15 am
Shuttle service from the Strathallan to the University of Rochester
A complementary shuttle bus will leave the hotel at 7:15 and at 7:45
Speakers are encouraged to arrive early to preload presentations by 7:45 AM

Session Six: AHR as a regulator of developmental pathways
Chair: Francisco Quintana, Brigham and Women’s Hospital (USA)

8:00 am
AHR regulates liver and endothelial development
Christopher Bradfield, University of Wisconsin (USA)

8:30 am
Interaction of the TCDD-AHR and MAPK pathways disrupts epithelial morphogenesis
Ying Xia, University of Cincinnati (USA)

9:00 am
AHR and the development of the vertebrate heart
Warren Heideman, University of Wisconsin (USA)

9:30 am
Break (Location: Flaum Atrium)
Beverages & light snacks

Session Seven: AHR signaling: Insights into therapeutic applications
Chair: Nancy Kerkvliet, Oregon State University (USA)

10:00 am
Targets of immunosuppressive tryptophan metabolism 
Michael Platten, University Hospital of Heidelberg (Germany)

10:30 am
Lessons learned from ancient coal tar therapy: The AHR as a therapeutic target for inflammatory skin diseases
Ellen van den Bogaard, Radboud University Medical Center (the Netherlands)

11:00 am
AHR is critical for skin barrier integrity and a target for dietary intervention
Charlotte Esser, Leibniz Research Institute for Environmental Medicine (Germany)

Session Eight: Emerging science II
Chair: Robert Barouki, Paris Descartes University (France)

11:30 am
AHR-dependent immunomodulatory effects of benzo(a)pyrene in activated bone marrow derived macrophages
Sina Riemschneider, Fraunhofer Institute for Cell Therapy and Immunology (Germany)

11:42 am
Identification of novel cellular pathways that contribute to AHR activation-induced CD8+ T dysfunction during influenza A virus infection
Christina Post, University of Rochester (USA)

11:54 am
Tryptophan metabolite activation of the AHR regulates IL-10 receptor expression on intestinal epithelia
Jordi Lanis, University of Colorado Anschutz Medical Campus (USA)

12:15 pm
Lunch and Poster Session II (Location: Flaum Atrium, LeChase Assembly Hall)

Session Nine: Upsides and downsides of AHR signaling
Chair: Raimo Pohjamvirta, University of Helsinki (Finland)

1:45 pm
Significance of AHR signaling on the mammalian brain development
Eiki Kimura, University of Tokyo (Japan)

2:15 pm
TIPARP and mono-ADP-ribosylation regulate AHR activity and dioxin toxicity
Jason Matthews, University of Oslo (Norway)

2:45 pm
Role of AHR signaling in effects on neurodevelopment in Vietnamese children perinatally exposed to agent orange
Muneko Nishijo, Kanazawa Medical University (Japan)

3:15 pm
Break (Location: Flaum Atrium)
Beverages, light snacks, and Ice Cream Truck

Session Ten: AHR as a mediator of inflammation
Chair: David Shepherd, University of Montana (USA)

3:45 pm
Role of AHR in inflammatory responses of human primary macrophages in response to environmental pollutants
Valerie Lecureur, University of Rennes 1 (France)

4:15 pm
Aryl hydrocarbon receptor signaling modifies toll-like receptor-regulated responses in dendritic cells
Christoph Vogel, University of California Davis (USA)

4:45 pm
Oculomotor deficits in AHR knockout mice: An inflammatory disease?
Xavier Coumoul, University Paris Descartes INSERM UMR-S 1124 (France)

Session Eleven: Emerging science III
Chair: Lisa Chadwick, National Institute of Environmental Health Sciences, NIH (USA)

5:15 pm
Expression of the AHR in cutaneous langerin-positive dendritic cells is crucial for disease development in a mouse model of systemic lupus erythematosus
Christoph Baumann, University of Münster (Germany)

5:27 pm
Long-term self-renewal of hematopoietic stem cells is dependent on proper regulation of mitochondria homeostasis and bioenergetics by the AHR during development
Michael Laiosa, University of Wisconsin-Milwaukee (USA)

5:39 pm
The aryl hydrocarbon receptor and its ligands inhibit myofibroblast formation and activation: Implications for thyroid eye disease
Collynn Woeller, University of Rochester (USA)

5:51 pm
Investigating the role of the AHR pathway in the pathogenesis of dry-age related macular degeneration
Goldis Malek, Duke University School of Medicine (USA)

6:03 pm
Adjourn

6:00 -7:00 pm
Shuttle service from the University of Rochester to the Strathallan
The bus will pick up conference attendees outside the Flaum Atrium exit at 6:00 and again at 6:30 PM

Saturday, August 6, 2016

University of Rochester School of Medicine and Dentistry (SMD)
601 Elmwood Avenue, Rochester, NY, 14642

All oral presentations are held in the Class of ’62 Auditorium

7:30  am
Shuttle service from the Strathallan to the University of Rochester
A complementary bus will leave the hotel at 7:30 and at 8:00
Speakers are encouraged to arrive early to preload presentations by 8:15 AM

Session Twelve: Role of AHR in immune regulation
Chair: Charlotte Esser, Leibniz Research Institute for Environmental Medicine (Germany)

8:30 am
TCDD-mediated impairment of human hematopoietic stem cell to B cell lineage commitment
Norbert Kaminski, Michigan State University (USA)

9:00 am
Consequences of AHR activation in dendritic cells
David Shepherd, University of Montana (USA)

9:30 am
Environmental exposures – The missing link in immune responses after transplantation
Joshua Mezrich, University of Wisconsin (USA)

10:00 am
Break (Location: Flaum Atrium)
Beverages & light snacks

Session Thirteen: AHR as a tool for disease prevention and treatment
Chair: Richard Phipps, University of Rochester (USA)

10:30 am
Novel benzoquinones as AHR-based therapeutics for immune-mediated disease
Nancy Kerkvliet, Oregon State University (USA)

11:00 am
Regulation of inflammation by AHR expressed in CNS resident cells
Francisco Quintana, Harvard University (USA)

11:30 am
AH receptor as a drug target for inhibiting cancer cell migration/invasion
Stephen Safe, Texas A&M University (USA)

12:00 pm
Meeting Summary
David Sherr

12:20 pm
Wrap up and Farewell
Paige Lawrence

12:30 pm
Conference Adjourns

12:45 pm
Complimentary shuttle service will be available from the University of Rochester to the Rochester Airport and Strathallan
 

ROC Fall Skyline

Please check back regularly for more information. If you have questions, please contact Ms. Laurie Furibondo (Laurie_Furibondo@URMC.Rochester.edu) or call +1-585-276-7277.