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CEL Online - Supporting Complex Care: Sickle Cell

Date of Release

Period of Validity
2/1/2017 - 2/1/2020

After reviewing the course information below, there will be a link to register for the activity.

Educational Need
The goal of this series of presentations on sickle cell disease is to give providers a broad understanding of evidence based diagnosis and management of acute complications of the disease.  Topics will include evidence based management of acute “pain” (vaso-occlusive crisis, acute chest), health system impact of disease management, and patient focused impact of disease.  We will also review resources and programs implemented in the Greater Rochester area that can be accessed directly or translated into other regional settings.

At the conclusion of this activity, participants should be able to:

  • Explain the impact of sickle cell disease on adult hospital care
  • Introduce the Complex Care Center and how it can support hospital based care teams
  • Discuss upcoming topics with a few clinical pearls about sickle cell management
  • Identify the diagnostic criteria for VOC and available biomarkers 
  • Discuss evidence based management of VOC
  • Discuss the role of transfusion in the management of VOC
  • Outline the impact of hydroxyurea and follow up care in VOC admission 
  • Describe the impact of sickle cell disease on patients in the community
  • Discuss the impact of hospital based care on patient engagement and perceptions of health care in general
  • Explain the impact of a medical home on health engagement and education
  • Describe the pathophysiology of sickle cell disease
  • Recognize the Health system impact of caring for adults with sickle cell disease 
  • Discuss quality of life and mortality in adults with sickle cell disease
  • Explain evidence based diagnosis & management of Vaso-occlusive Crisis
  • Explain evidence based diagnosis & management Acute Chest Syndrome
  • Identify Local resources for adults with sickle cell disease ​


Bibliographic Sources to Allow for Further Study:

  • Aisiku et al. Annals of Emerg Med, vol 53, no.5, pp587-593
  • McClish, et al. Pain 145 (2009) 246-251
  • Givens, et al. Journal of Emergency Med. Vol 3, No 3, pp 239-243
  • Okumura, et al. Arch Pediatric Adolescent Med. 2006. 160(10) 1054-60
  • Shah et al. Clin J of Pain. 2014
  • Journal of Pain Vol. 12, No 5, 2011, pp 531-538
  • Samir K. Ballas et al. Hematology 2012
  • Manwani, D. & Frenette, PS. Hematology, December 6, 2013 vol. 2013 no. 1 pp 362-369
  • Samir K. Ballas American J. Hematology 2007: 97-105
  • American Society of Hematology 2007
  • NIH. Evidence Based Management of Sickle Cell Disease, Expert Panel Report 2014
  • Ander DS, Vallee PA, Am J Emerg. Med. 15(3): 290-2, 1997 May
  • Pollack et al. Ann Emerg Med. 20 (11): 1210-4, 1991 Nov.
  • Ballas, SK, et al. Definitions of the phenotypic manifestations of sickle cell disease. Am J Hematol. 2010;85(1):6.
  • Castro, O, et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease.  July 15, 1994; Blood: 84 (2)
  • Powars, D, et al.  Sickle cell chronic lung disease: prior morbidity and the risk of pulmonary failure.  Medicine (Baltimore) 1988 Jan; 67(1): 66-76.
  • Charache, S, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332(20):1317.
  • Vichinsky, EP.  Causes and outcomes of the acute chest syndrome in sickle cell disease.  N Engl J Med. 2000; 342(25): 1855

The University of Rochester School of Medicine & Dentistry is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians.

The University of Rochester School of Medicine and Dentistry designates this enduring material for a maximum of 2.50 AMA PRA Category Credit(s)™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity

Planning Committee and Author/Speaker Declarations
The ACCME Standards of Commercial Support require that presentations be free of commercial bias and that any information regarding commercial products/services be based on scientific methods generally accepted by the medical community. All of the planning committee members (listed here) have declared that they have no financial interests or relationships to disclose:

*Tiffany Pulcino, MD, MPH

*Jane Tuttle, PhD, FN-BC

The following authors/speakers have disclosed financial interests/arrangements or affiliations with organizations that could be perceived as real or apparent conflict of interest in the context of the subject of their presentation(s).  Only the current arrangements/interests are included:

Katturah Guess - Speaker declared no financial interest or relationship exists.

No commercial funds have been received to support this educational activity.

Contact Information
For questions regarding certification or credit reports:
University of Rochester Medical Center
Center for Experiential Learning
Phone: (585) 275-7666

Registration Fees:



Criteria for Successful Completion of this Activity Include:

  • Register for the course
  • Review all course materials
  • Completion of  the self-assessment / program evaluation*

*The self-assessment / program evaluation must be completed in one sitting.


  • Will be available for download immediately following completion of the program evaluation.
  • Participants must download and save or print certificates before exiting the course.
  • Please remember to send a copy of your certificate to your credentialing office and to keep a copy for your records.

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