2013 Award Announcement

The Center for Integrative Bioinformatics and Experimental Mathematics (CIBEM) in the Department of Biostatistics and Computational Biology, University of Rochester Medical Center (URMC) recently issued a RFA for the bioinformatics collaboration pilot program to promote collaborations between CIBEM faculty members and experimental bioinformatics scientists. This pilot program is designed to support projects that require both innovative bioinformatics experimental technologies and novel bioinformatics/computational methods. Seven high-quality applications were received. All were reviewed by CIBEM faculty and two were selected to receive awards. Both awarded projects propose to produce multi-type, high-throughput bioinformatics data using novel technologies and approaches, which directly relate to the needs of developing innovative solutions for “Big Data” in biomedical research.

  • One award was given to Dr. Sina Ghaemmaghami, Assistant Professor from Department of Biology on River Campus in collaboration with Dr. Martin Zand from Department of Medicine, URMC. They proposed the project entitled “Quantitative proteomic analysis of influenza-infected mice,” which uses a novel proteomics technology to quantify protein turn-over rates under both steady-state and disturbed dynamics conditions by integrating a 15N labeling technique and time course gene expression data.
  • Another award was given to Dr. Stephen Dewhurst, Professor of Microbiology and Immunology (URMC) in collaboration with a junior faculty member, Dr. Polesskaya Oksana of the same department. They proposed the project entitled “Interaction between aging and HIV-associated neurological disorder,” which will integrate high-throughput RNA-Seq data with two-photon imaging technology to study HIV associated neurological disorders.

Both projects present challenges that will require development of complex computational modeling and novel analysis approaches by CIBEM faculty members. Investigators that consulted and closely collaborated with CIBEM faculty members from the beginning of the proposal development were able to develop a more successful application.

The next RFA solicitation cycle for the bioinformatics collaboration pilot program will be released in January 2014.