Reactions that Lead to the Formation of Radicals that are Trapped in DNA

Radical trapping and reactions are being measured in a series of DNA crystals, testing our working model. Imbedded in the model are a number of specific hypotheses, such as:

  1. holes are initially trapped on sugar and guanine in a ratio of ˜1:3, and
  2. while most (~70%) of the electrons are initially trapped by reversible proton transfer to one-electron reduced cytosine, there is an important fraction (˜20%) that are trapped by irreversible proton transfer to the C5-C6 bond of reduced cytosine and thymine.

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