Principal Investigator

Dirk Bohmann, Ph.D. University of Rochester work Box 633 601 Elmwood Ave Rochester NY 14642 office: KMRB 2-9639 p (585) 273-1446

Research Projects

  • JNK, Oxidative Stress and Aging

    JNK, Oxidative Stress and Aging

    We are interested in the relationship between cellular oxidative stress defense and aging. Previous data showed that JNK signaling can induce a genetic program that confers stress resistance, and that active JNK signaling can prolong lifespan in Drosophila. Further, we showed that the life-extending effect of JNK is mediated by activation of the transcription factor Foxo (a.k.a. Daf 16 in C. elegans) and by suppressing the effects of insulin/IGF signaling. More info...

  • NRF2 Signaling

    NRF2 Signaling

    Nrf2 is a signal-activated transcription factor that had previously been characterized in mammals, where it mediates responses to electrophiles, oxidative stress and carcinogens. Nrf2-induced processes protect many organs, including the gastrointestinal tract and the nervous system, from xenobiotic damage. Importantly, Nrf2 is a prominent target for cancer chemo-preventive interventions and Nrf2-activating agents are currently being evaluated for therapeutic utility in clinical trials. More info...

  • Drosophila as a Cancer Model

    Drosophila as a Cancer Model

    Previous research in the lab showed that JNK signaling activates genes that are required for epithelial movements and morphogenesis during embryonic development. Integrins and profilin were identified as important mediators of this response. More recently, we have turned to the role of JNK signaling in pathological cell movements. By generating clones of malignant cells in eye imaginal discs we can model tumor behavior in vivo. More info...