Principal Investigator

Lisa A. DeLouise, Ph.D., M.P.D. University of Rochester work Box 697 601 Elmwood Ave Rochester NY 14642 office: MC 6-6823 p (585) 275-1810 f (585) 273-1346

Honors & News

  • July 8, 2016

    Lisa A. DeLouise Receives Patent for Microfluidic Device

    Lisa A. DeLouise, Ph.D., M.P.D., associate professor of Dermatology, Biomedical Engineering, Material Chemistry and Electrical and Computer Engineering and a member of the Environmental Health and Science Center, has received a patent for her microfluidic device and a method of manufacturing the device.

    Research in the DeLouise Lab – funded by NYSTAR, NSF, DCFAR, CTSI and URVentures – has led to the development of a single cell screening technology platform based on microbubble well array. Single cell screening technologies can facilitate the discovery of rare cells.

    DeLouise's current work, in collaboration with James J. Kobie, Ph.D., assistant professor of Infectious Diseases, seeks to sort antigen-specific antibody-secreting B cells for the development of therapeutic monoclonal antibodies and the detection of cancer stem cells that harbor genetic mutations that confer their tumor-initiating and drug-resistant properties.

  • October 6, 2015

    Success Stories: Pilot Grants lead to R01, new business

    Lisa DeLouise, Ph.D., M.P.D., associate professor of Dermatology, has received two Pilot Grants from the CTSI, each of which helped to support a line of research that blossomed into much more. She shared her experiences with CTSI Stories.

    The first one I got was in 2007, and it was for nanoparticle skin research. I look at cosmetic products to see if they have efficacy and any unintended toxicity issues, and back in 2006, I got involved in the question of whether nanoparticles that are increasingly formulated into various topical cosmetic products have any of these side effects.

    In sunscreens, for example, there are ingredients that can have unintended biological consequences, so I was looking at a couple compounds used in sunscreens – titanium oxide and zinc oxide – which absorb UV light so your skin is protected. When these compounds were first used, they were approved by the FDA at the micron level – so, relatively speaking, the particles were too large to seep through skin.

  • June 18, 2015

    Brian Palmer Wins Best Overall Poster by a Student or Postdoc at Toxicology Retreat

    Congratulations to Brian Palmer, a Toxicology graduate student in Lisa DeLouise's lab on winning Best Overall Poster by a Student or Postdoc at the 2015 Toxicology Department Retreat. Brian's current research focus is investigating the epidermal penetration of topically applied nanoparticles and the effect they have on skin resident immune cells in a murine model.

  • May 15, 2015

    Chitavi Devi Maulloo Awarded 2015 Janet Howell Clark Prize

    The 2015 Janet Howell Clark Prize is being awarded to Chitavi Devi Maulloo (CHM BS, BMG BS '15). The Janet Howell Clark Prize is awarded annually to a senior woman who has shown the greatest promise in creative work in astronomy, biology, chemistry, or physics, and who has shown outstanding versatility in the mastery of allied fields. Selection is based on recommendations by the respective departments, which are evaluated by a committee appointed by the Dean of the College. The award consists of a cash prize and recognition at a special senior ceremony the Saturday of commencement. Chitavi will also be recognized at the Chemistry Diploma Ceremony.

  • February 11, 2015

    Former DeLouise Lab Member, Luke Mortensen Promoted to Assistant Professor at University of Georgia

    Luke Mortensen, Ph.D.

    Former BME graduate student in Lisa DeLouise's lab, Luke Mortensen, Ph.D. has been promoted at the University of Georgia to Assistant Professor in Regenerative Medicine and Engineering.

    Luke's current research focuses on intravital microscopy development for the study of tissue regeneration. Currently his lab is using custom multiphoton microscope to elucidate the mechanism of mesenchymal stem cell (MSC) therapy in congenital bone diseases like osteogenesis imperfecta.

    Congratulations Luke!

  • November 5, 2014

    Chitavi Maulloo Wins the Junior Scholar Award and the Catherine Block Memorial Fund Prize

    Chitavi Maulloo

    On Oct 8, 2014 Chitavi Maulloo, a student in Lisa DeLouise's lab won the Junior Scholar Award and the Catherine Block Memorial Fund Prize from the Department of Chemistry. The Junior Scholar Award for Juniors is given to a chemistry student in the junior class, in recognition of outstanding accomplishment and promise for a professional career in chemistry. This award consists of a cash prize and certificate of recognition. The recipients are announced at the Chemistry Awards Get-Together in the Fall semester.

    The Catherine Block Memorial Fund Prize, established in memory of Catherine Block, an exceptional Chemistry student here at the University, is awarded each year to a woman in the Junior class in recognition of her outstanding ability and achievement in the field of science. The award consists of a cash prize. The recipient will be recognized at the Chemistry Awards Get-Together in the Fall semester.

  • June 4, 2014

    Brian Palmer Wins Two Awards at Toxicology Retreat

    Brian Palmer

    Congratulations to Brian Palmer, a Toxicology graduate student in Lisa DeLouise's lab on winning two awards at the Annual Toxicology Retreat. Brian won the department 'Question" Award given to the student who asks the most insightful questions throughout the year at department seminars and also won the McGregor Award for best poster presentation by a first year graduate student.

  • May 6, 2014

    Quhui (Fiona) Pu Wins the 2014 Charles and Janet Forbes Entrepreneurial Competition

    On May 2, 2014 Fiona Pu and Kyle Fedorchak won first place in the 2014 Charles and Janet Forbes Entrepreneurial Competition. They presented a business plan to commercialize a device that enables the testing of biological membranes including measurements of skin barrier function. This device product concept was developed in collaboration with fellow UR Dermates colleagues, Amanda Chen and Jacob VanderBurgh, while working on their Biomedical Engineering senior design project. Internal product customers were Drs. Beck and DeBenedetto (Dermatology) and the team was supervised by Dr. DeLouise (Dermatology and BME).

  • April 19, 2014

    Jared Fialkoff Wins The President’s Award at UR Undergraduate Symposium

    On April 18, Jared Fialkoff won the highest honor, The President’s Award at the University of Rochester Undergraduate Symposium for his research and oral talk entitled, Gold Nanoparticle (AuNP) siRNA Delivery to Treat Allergic Contact Dermatitis. Jared is a Chemical Engineering undergrad working in Lisa DeLouise's lab.

  • July 30, 2013

    Rochester Has New Big Employers

    Kodak, Bausch and Lomb, and Xerox were without question Rochester's biggest employers for decades. "We're moving from more manufacturing based employment to a more service based employment," Rochester Business Alliance CEO Sandy Parker explained. Even if you look at companies that still employ significant numbers here, like Xerox, they themselves are moving away from manufacturing and more towards being service providers.

    Dr. Lisa DeLouise found a new career at the University of Rochester Medical Center after working at Xerox for 16 years. We thought we were pulled together to have a meeting to hear about investors in our technology, explained DeLouise. And when we were told we were all being laid off, it was a bit of a shock. DeLouise is now an associate professor of dermatology and biomedical engineering.

  • July 5, 2011

    DeLouise and King Publish Article in Virtual Journal of Biological Physics Research

    Lisa DeLouise and Mike King (Cornell) have recently published an article, Continuously perfused microbubble array for 3D tumor spheroid model, in the June 15, 2011 issue of Virtual Journal of Biological Physics Research. The Virtual Journal, which is published by the American Physical Society and the American Institute of Physics in cooperation with numerous other societies and publishers, is an edited compilation of links to articles from participating publishers, covering a focused area of frontier research.

  • September 30, 2008

    When Particles Are So Small That They Seep Right Through Skin

    Scientists are finding that particles that are barely there – tiny objects known as nanoparticles that have found a home in electronics, food containers, sunscreens, and a variety of applications – can breach our most personal protective barrier: The skin.

    The particles under scrutiny by Lisa DeLouise, Ph.D., are almost unfathomably tiny. The particles are less than one five-thousandth the width of a human hair. If the width of that strand of hair were equivalent to the length of a football field, a typical nanoparticle wouldn't even belly up to the one-inch line.

  • September 9, 2008

    Cancer Cells Need Salting Before Cooking

    Korean scientists have used table salt to help them move closer to creating a porous silicon nanobomb that will literally blow up cancerous cells. Thermotherapy - that uses near infra-red (NIR) light to destroy cells - stopped being used in the 1990s, but thanks to new research is making a comeback as a possible alternative to currently available therapies for removing cancerous cells. Recently agents such as carbon nanotubes - that emit heat after irradiation with NIR - have been tried in combination with thermotherapy to kill cancer cells selectively.

    Lisa DeLouise, Ph.D., an expert in porous silicon at the University of Rochester Medical Centre in the US, says 'nanoparticle thermotherapy is an emerging field with great potential for biomedical research'.

  • August 20, 2008

    Sun Damage May Exacerbate Skin Penetration of Nano-sunscreens

    Nanoparticles may penetrate sun damaged skin causing concern about their increasingly widespread use in sunscreens, according to new research. In a paper published in Nano Letters, scientists at the University of Rochester found that quantum dot nanoparticles penetrated UV damaged skin more than non-compromised skin.