Our laboratory has demonstrated that persistent activation of AhR by dioxin results in altered numbers and functions of hematopoietic stem cells (HSCs) in mouse bone marrow. Combined with data showing that a lack of AhR function also results in altered HSC characteristics and hematopoietic diseases (such as leukemia), our findings strongly suggest that a normal role for AhR may be to regulate HSC’s. The lab is currently studying this connection as well as how changing AhR regulation and function leads to hematopoietic diseases.
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Several epidemiological studies and clinical trials have shown the effectiveness of green tea (GT) extract for the prevention of UV-induced skin injuries, oxidative DNA damage, as well as prostate cancer. Epigallocatechin-3-gallate (EGCG), a major antioxidant in GT, has been suggested to target several biomedically relevant molecules and disease-related cellular processes. However, the precise molecular and cellular mechanisms by which EGCG acts to modulate tumor growth have yet to be determined.
Learn more about Interactions of EGCG and Hsp90 in Oncogenesis