URMC / Labs / Gasiewicz Lab / Publications Recent Publications Zhai WSun YJiang MWang MGasiewicz TAZheng JChang C (2016 Mar 14). Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia. Oncogene. Moses MAHenry ECRicke WAGasiewicz TA (2015 Mar). The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model. Cancer prevention research (Philadelphia, Pa.). Bhat RAdam ATLee JJGasiewicz TAHenry ECRotella DP (2014 May 15). Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors. Bioorganic & medicinal chemistry letters. Gasiewicz TASingh KPBennett JA (2014 Mar). The Ah receptor in stem cell cycling, regulation, and quiescence. Annals of the New York Academy of Sciences. Bennett JASingh KPUnnisa ZWelle SLGasiewicz TA (2015). Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells. PloS one. Singh KPBennett JACasado FLWalrath JLWelle SLGasiewicz TA (2014 Jan 15). Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice. Stem cells and development. Casado FLSingh KPGasiewicz TA (2011 Oct). Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration. Molecular pharmacology. Singh KPGarrett RWCasado FLGasiewicz TA (2011 May). Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions. Stem cells and development. Latchney SELioy DTHenry ECGasiewicz TAStrathmann FGMayer-Pröschel MOpanashuk LA (2011 Feb). Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Stem cells and development. Laiosa MDMills JHLai ZWSingh KPMiddleton FAGasiewicz TASilverstone AE (2010 May). Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation. Molecular pharmacology. Casado FLSingh KPGasiewicz TA (2010 Apr 15). The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases. Blood cells, molecules & diseases. Gasiewicz TASingh KPCasado FL (2010 Mar 19). The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity. Chemico-biological interactions. Henry ECWelle SLGasiewicz TA (2010 Mar). TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts. Toxicological sciences : an official journal of the Society of Toxicology. Singh KPCasado FLOpanashuk LAGasiewicz TA (2009 Feb 15). The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochemical pharmacology. Yin ZHenry ECGasiewicz TA (2009 Jan 20). (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. Biochemistry. Singh KPWyman ACasado FLGarrett RWGasiewicz TA (2009 Jan). Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells. Carcinogenesis. Vezina CMAllgeier SHMoore RWLin TMBemis JCHardin HAGasiewicz TAPeterson RE (2008 Dec). Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate. Toxicological sciences : an official journal of the Society of Toxicology. Baglole CJMaggirwar SBGasiewicz TAThatcher THPhipps RPSime PJ (2008 Oct 24). The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. The Journal of biological chemistry. Collins LLWilliamson MAThompson BDDever DPGasiewicz TAOpanashuk LA (2008 May). 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicological sciences : an official journal of the Society of Toxicology. Henry ECGasiewicz TA (2008 Apr 15). Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. Archives of biochemistry and biophysics. Gasiewicz TAHenry ECCollins LL (2008). Expression and activity of aryl hydrocarbon receptors in development and cancer. Critical reviews in eukaryotic gene expression. Ryan EPHolz JDMulcahey MSheu TJGasiewicz TAPuzas JE (2007 Oct). Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Thatcher THMaggirwar SBBaglole CJLakatos HFGasiewicz TAPhipps RPSime PJ (2007 Mar). Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. The American journal of pathology. Bemis JCAlejandro NFNazarenko DABrooks AIBaggs RBGasiewicz TA (2007 Jan). TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. Toxicological sciences : an official journal of the Society of Toxicology. Kim SHHenry ECKim DKKim YHShin KJHan MSLee TGKang JKGasiewicz TARyu SHSuh PG (2006 Jun). Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Molecular pharmacology. Henry ECBemis JCHenry OKende ASGasiewicz TA (2006 Jun 1). A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Archives of biochemistry and biophysics. Garrett RWGasiewicz TA (2006 Jun). The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms, quiescence, and expression of clock genes in murine hematopoietic stem and progenitor cells. Molecular pharmacology. Bemis JCNazarenko DAGasiewicz TA (2005 Oct). Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Toxicological sciences : an official journal of the Society of Toxicology. Martey CABaglole CJGasiewicz TASime PJPhipps RP (2005 Sep). The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. American journal of physiology. Lung cellular and molecular physiology. Palermo CMWestlake CAGasiewicz TA (2005 Apr 5). Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry. Williamson MAGasiewicz TAOpanashuk LA (2005 Feb). Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. Filbrandt CRWu ZZlokovic BOpanashuk LGasiewicz TA (2004 Jun). Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. Minsavage GDPark SKGasiewicz TA (2004 May 14). The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation. The Journal of biological chemistry. Laiosa MDWyman AMurante FGFiore NCStaples JEGasiewicz TASilverstone AE (2003 Nov 1). Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor. Journal of immunology (Baltimore, Md. : 1950). Joiakim AMathieu PAPalermo CGasiewicz TAReiners JJ (2003 Nov). The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug metabolism and disposition: the biological fate of chemicals. Zhou JGasiewicz TA (2003 Aug 1). 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism. Archives of biochemistry and biophysics. Palermo CMHernando JIDertinger SDKende ASGasiewicz TA (2003 Jul). Identification of potential aryl hydrocarbon receptor antagonists in green tea. Chemical research in toxicology. Zhou JGHenry ECPalermo CMDertinger SDGasiewicz TA (2003 Apr). Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. Molecular pharmacology. Minsavage GDVorojeikina DPGasiewicz TA (2003 Apr 1). Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements. Archives of biochemistry and biophysics. Henry ECGasiewicz TA (2003 Feb). Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis. Molecular pharmacology. Laiosa MDLai ZWThurmond TSFiore NCDeRossi CHoldener BCGasiewicz TASilverstone AE (2002 Sep). 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicological sciences : an official journal of the Society of Toxicology. Wyman ALavin ALWilding GEGasiewicz TA (2002 May 1). 2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system. Toxicology and applied pharmacology. Nazarenko DADertinger SDGasiewicz TA (2001 Jun). In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice. Toxicological sciences : an official journal of the Society of Toxicology. Nazarenko DADertinger SDGasiewicz TA (2001 Apr). Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates. BioTechniques. Dertinger SDNazarenko DASilverstone AEGasiewicz TA (2001 Jan). Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. Carcinogenesis. Thurmond TSGasiewicz TA (2000 Nov). A single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin produces a time- and dose-dependent alteration in the murine bone marrow B-lymphocyte maturation profile. Toxicological sciences : an official journal of the Society of Toxicology. Lai ZWFiore NCHahn PJGasiewicz TASilverstone AE (2000 Oct 1). Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicology and applied pharmacology. Park SHenry ECGasiewicz TA (2000 Sep 15). Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation. Archives of biochemistry and biophysics. Dertinger SDLantum HBSilverstone AEGasiewicz TA (2000 Jul 15). Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. Biochemical pharmacology. Thurmond TSMurante FGStaples JESilverstone AEKorach KSGasiewicz TA (2000 Jul). Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Endocrinology.