Principal Investigator

Hartmut Land, Ph.D. University of Rochester work Box 633 601 Elmwood Ave Rochester NY 14642 office: KMRB 2-9633 p (585) 273-1142

CRG Expression Profiles as Indicators for Drug Efficacy and Mechanism

Due to the essential role of cooperation response genes (CRGs) in malignant cell transformation, CRG expression profiles reflect the causal underpinnings of the malignant state at molecular level. The utility of gene expression profiles for classification of drug function has been established through the work of others. We have developed technologies for in silico screening of cooperation response gene expression profiles in response to drug challenge. In this context, we predict that CRG expression profiles can be effectively used for identification of cancer ablative drugs. This path of investigation is aimed at facilitating translation of our discoveries into clinical application.

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