Principal Investigator

Stephen A. McAleavey, Ph.D University of Rochester work Box 270168 Rochester NY 14627-0168 office: Goergen Hall 309 p (585) 275-7768 f (585) 276-1999

Honors & News

  • May 5, 2016

    Jonathan Langdon wins Outstanding Dissertation Award for Engineering

    Jonathan Langdon

    Congratulations to graduate student Jonathan Langdon of the McAleavey Lab who received the prestigious Outstanding Dissertation Award for Engineering this year. This honor attests to Jonathan's exceptional work in the field of biomedical ultrasound and comes with a monetary award of $1,000. His thesis was titled, Development of Single Track Location Shear Wave Viscoelasticity Imaging for Real-Time Characterization of Biological Tissues.

    "Jonathan was an outstanding PhD student in our biomedical engineering program, said Diane Dalecki, director of the Rochester Center for Biomedical Ultrasound, and professor of biomedical engineering. His dissertation research made significant advances in new ultrasound elastography technologies for measuring and visualizing viscoleastic properties of tissues. I am delighted to see Jonathan's work recognized with this award.

    The summary of Jonathan's research project is below:

    Development of Single Track Location Shear Wave Viscoelasticity Imaging for Real-Time Characterization of Biological Tissues In response to chronic inflammation, many tissues undergo a transformation known as fibrosis that results in increased stiffness of the tissue. The parenchyma of the liver is one such tissue and may undergo fibrotic change as a result of a number of chronic diseases. The gold standard for monitoring the progression of chronic liver disease is biopsy. However, it is associated with a non-trivial morbidity. Therefore, non-invasive methods of assessing disease state are being sought. Elastography is a set of measurement methods that allow for the non-invasive estimation of tissue stiffness. Unfortunately, distinguishing between early stages of fibrosis has proven to be a challenge since a high level of measurement precision is required. Single Tracking Location Shear Wave Elasticity Imaging (STL-SWEI) is an elastography method that has been shown to improve measurement precision by compensating for speckle-induced bias. This method was previously investigated in the setting of liver fibrosis using a rat model. However, the precision of the measurements proved to be inadequate to distinguish the very earliest fibrosis stages. Additionally, it is unclear from the previous work that the Single Tracking Location per se is responsible for any measurement improvement. In this work, the STL-SWEI method is improved upon by introducing a real-time imaging software suite with matched implementations of both STL and Multiple Tracking Location (MTL) SWEI.

    Additionally, a novel viscoelastic estimator is implemented based on Maximum Likelihood Estimation theory. Third, a suite of graphic processing unit (GPU) accelerated simulation tools are introduced that allow for the simulation of SWEI images and exploration of the effects of boundary conditions on SWEI estimates. Finally, the ability of STL-SWEI to distinguish between stages of fibrosis in rat liver is re-evaluated using these new tools and directly compared to MTL-SWEI.

  • March 7, 2016

    Steve McAleavey Receives 9th Percentile Score for Grant Supporting Ultrasound Imaging Research

    BME Professor Stephen McAleavey recently received a 9th percentile score for his R21 grant entitled, "Quantification of Shear Wave Strain Dependence in Breast Tissues. Many women presently undergo breast biopsy due to lesions detected with x-ray and ultrasound imaging. The great majority of these biopsies are negative, resulting in needless expense and worry. The goal of this project is to improve the power of ultrasound imaging to predict if a breast lesion is benign or malignant. This will be achieved by a novel, high resolution technique to non-invasively map the non-linear mechanical properties of breast tissue. These properties are determined by the microstructure of the tissue and show marked differences between benign and malignant tissues.

    This project will combine the efforts of faculty in HSEAS (Stephen McAleavey, PhD in BME, Marvin Doyley, PhD in ECE) and the URMC (Linda M. Schiffhauer, MD in Pathology, and Avice O'Connell, MD in Imaging Sciences).

  • April 29, 2015

    BME Professor Steve McAleavey Awarded PumpPrimer II Grant

    BME Professor Steve McAleavey has been awarded a University of Rochester PumpPrimer II grant for his research project titled “Towards Diagnostic Ultrasonic Imaging of Tissue Non-Linearity: Strain Dependence of Shear Wave Velocity in Liver and Breast Tissue.” 

    This project is a first step towards a long-term goal of characterizing non-linear mechanical properties of tissues non-invasively and in vivo with ultrasound, with application to clinical disease monitoring as well as basic research. 

  • November 17, 2014

    New Ultrasound Imaging Patent Issued for Professor McAleavey

    Graduate student Jonathan Langdon (left) and Professor McAleavey in the lab.

    The patent titled Methods and Systems for Spatially Modulated Ultrasound Radiation Force Imaging (US 8753277) has recently been assigned to the UR with inventor Stephen A. McAleavey. The patent describes a new method for using ultrasound to determine the shear modulus of a tissue noninvasively. Changes in shear modulus of tissues can be associated with certain pathologies, such as cancer and liver fibrosis. Thus, Professor McAleavey’s new ultrasound technology holds great promise for increasing early detection and diagnosis of disease in patients. Stephen McAleavey is an Associate Professor of Biomedical Engineering, and member of the Rochester Center for Biomedical Ultrasound (RCBU).

  • May 6, 2013

    Upstate Researchers Tackle Toilet Training for Autistic Children

    Researchers in upstate New York have developed a wearable sensor system that will help toilet train autistic children. The device, created at the University of Rochester, involves a moisture pager that can connect to a smartphone app and alert caregivers to accidents.

    It seems like something that you would think already exists, and it doesn't, says Stephen McAleavey, a biomedical engineering professor, and part of the team that developed the technology. So the goal with this was to develop a wireless device that could be used to monitor children - for when they're having an accident - and to try to make it as easy to use for the parents or the caregivers as possible.

  • August 6, 2012

    Professor McAleavey Awarded Patent

    A conventional ultrasound image (left) is insensitive to the stiffness or shear modulus of tissue, as shown in this image of a test object with a 1 cm stiff inclusion. The greater modulus of the inclusion is clearly revealed in the SMURF image (right).

    Professor Stephen McAleavey of the Department of Biomedical Engineering has been awarded a new U.S. Patent. The patent, number 8,225,666, is titled Ultrasound Imaging of Tissue Stiffness by Spatially Modulated Acoustic Radiation Force Impulse. The patent details a new ultrasound elastography technique, termed SMURF imaging, that uses acoustic radiation force to quantify tissue stiffness. Tissue stiffness is a known indicator of disease. Thus, this new technology will be useful clinically to noninvasively diagnosis fibrosis, cancerous tumors, vascular diseases, and monitor the progress of ablation therapies. Professor McAleavey is an active member of the Rochester Center for Biomedical Ultrasound (RCBU).

  • June 5, 2012

    What's Innovocracy?

    A local company is connecting innovators with people who want to fund their inventions. Their first venture is with the University of Rochester. Researchers at the University of Rochester come up with a lot of inventions that, if they had money, would be extremely helpful to the public. So what Innovocracy wants to do is link up inventors at the institutions like the U of R with people who want to help those inventions become marketable.

    Despite it being summer at the University of Rochester, researchers are still busy working. Dr. Stephen McAleavey, UR Researcher, said, We got a team of 4 or 5 of our seniors to work on the project for a semester.

  • April 15, 2011

    Students and Faculty Recognized at the Undergraduate Research Symposium

    BME professor Laurel Carney, Ph.D. (with Kelli Summers, and Benjamin Freedman) was recognized by the Student Association as the Engineering Professor of the Year.

    Congratulations to the RCBU and BME students whose work was recognized at the prestigious annual University of Rochester Undergraduate Research Exposition 2011. Undergraduate students from RCBU and BME research laboratories participated in the symposium. BME undergrads Benjamin Freedman '11 and Kelli Summers '11 were both invited to speak at the Engineering and Applied Sciences Symposium Talks.

    Freedman discussed his work, What is Q-Angle really measuring? A novel alternative to predict patellar maltracking, which received the Dean's Award. Summers spoke about her research with Dr. James McGrath, Mechanisms Underlying Collective Cell Migration in Vitro, which was recognized by President Seligman with the President's Award. Aaron Zakrzewski (ME '11), mentored by Mechanical Engineering Professor Sheryl Gracewski, gave an oral presentation of his research titled Natural frequency of bubbles within rigid and compliant tubes. Aaron also received a Deans' Award for Undergraduate Research in Engineering and Applied Sciences for his presentation. In addition, five of the seven poster exhibitions from the Hajim School of Engineering and Applied Sciences were by BME students:

    Molly Boutin (Benoit Lab) BME '11
    A Polymeric Delivery System to Induce Differentiation in hMSCs
    Jasmine Carvalho (Dalecki Lab) BME '11
    Investigations of Ultrasound Parameters to Promote Spatial Organization of Cells in Three-Dimensional Engineered Tissues
    Vlabhav Kakkad (McAleavey Lab) BME '12
    Experimental Implementation of Shear Wave Induced Phase Encoding Imaging
    Angela Ketterer (Carney Lab) BME '12
    Design and Implementation of a Behavioral Apparatus for Auditory Research in Birds
    Hannah Watkins (Benoit Lab) BME '11
    Novel Parthenolide Delivery System for Acute Myeloid Leukemia Treatment
    (Received the Professor's Choice Award)
  • July 6, 2010

    Dr. McAleavey Promoted to Associate Professor with Tenure

    Congratulations to Dr. Stephen McAleavey (BME), who was promoted from assistant professor to associate professor with tenure. Professor McAleavey has been with the University of Rochester since 1996, when he worked as a graduate research associate with Professor Kevin Parker in Electrical Engineering. He became assistant professor with the Department of Biomedical Engineering in 2004.

    Dr. McAleavey's area of research expertise centers on developing novel ultrasound imaging techniques based on shear waves. His research has led to the development of three patents: Method for Image Reconstruction from Shear Wave Modulated Ultrasound Echo Data; Shear Modulus Estimation by Application of Spatially Modulated Impulsive Acoustic Radiation Force; and Methods, Systems, and Computer Program Products for Imaging using Virtual Extended Shear Wave Sources (in conjunction with GE Trahey, KR Nightingale, and RW Nightingale).

  • December 16, 2009

    Congratulations to Dr. McAleavey!

    Congratulations to Dr. Stephen McAleavey on the birth of his first child. Stephen and his wife welcomed a daughter, Laura Katherine McAleavey, on December 15. She weighed in at 7 pounds 3 ounces, was 20.7 inches long, arrived at 9:29 AM. Mom and baby are both doing well.

  • May 18, 2009

    RCBU Members Attend Acoustical Society of America Meeting

    The RCBU was well represented at the Meeting of the Acoustical Society of America held in Portland, Oregon on May 18-22, 2009, with the following presentations: Ultrasound Standing Wave Fields Control the Spatial Distribution of Cells and Protein in Three-Dimensional Engineered Tissue by Kelley A. Garvin, Denise Hocking, and Diane Dalecki. Kelley Garvin won the Best Student Paper Competition in the Biomedical Ultrasound/Bioresponse to Vibration Technical Section with this paper. Lung Hemorrhage Produced by Exposure to Underwater Acoustic Impulses by Diane Dalecki, Sally Z. Child, and Carol H. Raeman. Comparison of Unconfined Compression and Spatially Modulated Ultrasound Radiation Force Estimates of Shear Modulus by Stephen McAleavey, Erin Collins, Johanna Kelly, Etana Elegbe, and Manoj Menon.

  • December 1, 2007

    RCBU Members Receive Grant to Develop Tool for Early Detection and Monitoring of Liver Disease

    RCBU members Kevin Parker (PI), Robert Lerner, Stephen McAleavey, and Diane Dalecki received funding from the Stanford University Center on Longevity for the project titled, Elastography in the Early Detection and Management of Liver Disease. The goal of this project is to develop a safe, non-invasive, inexpensive tool for the early detection and monitoring of liver disease.

  • December 1, 2007

    The Stanford Center on Longevity Awards Stephen McAleavey, Ph.D. Grant to Study Incontinence Management

    Stephen McAleavey (PI) was awarded a grant from the Stanford Center on Longevity for research on a Wireless Urine Monitor and Aids for Bladder Training and Incontinence Management. The goal of this project is to develop an assistive device for bladder training. The device, which incorporates a disposable sensor and wireless monitor, records the time of incontinence episodes. Urinary incontinence affects at least 10% of the age 65 or older population, and as many as 60% of those living in nursing homes.

  • September 24, 2007

    NIH awards grant to study Ultrasound Technologies for Tissue Engineering

    Diane Dalecki, Ph.D. and Denise Hocking, Ph.D., serve as multi-PIs on a grant from the NIH NIBIB titled Ultrasound Technologies for Tissue Engineering. The overall goal is to develop ultrasound-based enabling technologies for the fabrication and monitoring of functional, 3D artificial tissues. Through the project, they will develop the use of ultrasound to regulate the structure and organization of the extracellular matrix in order to stimulate cell processes that are critical for engineering functional tissue constructs. Current studies are testing the ability of ultrasound to produce conformational changes in fibronectin, an extracellular matrix protein that plays key roles in regulating cell growth and migration. Working with co-investigators Stephen McAleavey, Ph.D. and Sheryl Gracewski, Ph.D., the team is also developing and applying new ultrasound imaging and tissue characterization techniques to noninvasively monitor the material and biological properties of engineered tissues, and to validate the measurements through mechanical testing and finite element modeling.

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