Welcome to the Rahman Lab
My laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation and DNA methylation), involvement of anti-inflammatory and anti-aging proteins sirtuins, HDACs, DNA damage/repair, and cellular senescence in chronic lung inflammatory diseases including COPD. Recent research includes in understanding the role of sirtuins/HDACs in aging and accelerated decline in lung function, cellular senescence, and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in the pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants (tobacco smoke, e-cigarettes, oxidants/aldehydes), identifying molecular targets, and the potential benefit of therapeutic interventions in airways disease.
Current Research Projects
Inflammation, Advancing Age and Nutrition, 1st Edition
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- Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.Am J Respir Cell Mol Biol. 53, 782-92. (2015 Dec 01).
- Circadian molecular clock in lung pathophysiology.Am J Physiol Lung Cell Mol Physiol. 309, L1056-75. (2015 Nov 15).
- Comparison of Clinical and Radiographic Periodontal Status Among Habitual Waterpipe Smokers and Cigarette Smokers.J Periodontol, 1-9. (2015 Oct 02).