Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.
We made the remarkable discovery that C. albicans evolved an unusual mechanism of survival in adverse environments that cause lethality or inhibit growth. Using four different environments, we demonstrated that this naturally diploid microbe survived in a specific environment by altering a specific chromosome. Alterations included loss and gain of the entire chromosomes or loss and gain of the large portions of chromosomes. For example, survival on the medium containing the toxic sugar L-sorbose involved predominantly the formation of monosomy of chromosome 5 (Ch5).
- Chromosome 5 of human pathogen Candida albicans carries multiple genes for negative control of caspofungin and anidulafungin susceptibility.Antimicrob Agents Chemother, . (2016 Oct 10).
- Stabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway.J Thromb Haemost. 14, 1021-30. (2016 May 01).
- Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.J Thromb Haemost. 13, 1843-53. (2015 Oct 01).