URMC / Labs / Topham Lab / Publications Publications Lambert Emo KHyun YMReilly EBarilla CGerber SFowell DKim MTopham DJ (2016 Sep). Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen. PLoS pathogens. Jegaskanda SLuke CHickman HDSangster MYWieland-Alter WFMcBride JMYewdell JWWright PFTreanor JRosenberger CMSubbarao K (2016 Jun 28). The generation and protective ability of influenza-specific antibody-dependent cellular cytotoxicity in humans elicited by vaccination, natural infection or experimental challenge. The Journal of infectious diseases. DeDiego MLAnderson CSYang HHolden-Wiltse JFitzgerald TTreanor JJTopham DJ (2016 Jun). Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection. Immunology. Szafranski PGambin TDharmadhikari AVAkdemir KCJhangiani SNSchuette JGodiwala NYatsenko SASebastian JMadan-Khetarpal SSurti UAbellar RGBateman DAWilson ALMarkham MHSlamon JSantos-Simarro FPalomares MNevado JLapunzina PChung BHWong WLChu YWMok GTKerem EReiter JAmbalavanan NAnderson SAKelly DRShieh JRosenthal TCScheible KSteiner LIqbal MAMcKinnon MLHamilton SJSchlade-Bartusiak KEnglish DHendson GRoeder ERDeNapoli TSLittlejohn ROWolff DJWagner CLYeung AFrancis DFiorino EKEdelman MFox JHayes DAJanssens SDe Baere EMenten BLoccufier AVanwalleghem LMoerman PSznajer YLay ASKussmann JLChawla JPayton DJPhillips GEBrosens ETibboel Dde Klein AMaystadt IFisher RSebire NMale AChopra MPinner JMalcolm GPeters GArbuckle SLees MMead ZQuarrell OSayers ROwens MShaw-Smith CLioy JMcKay Ede Leeuw NFeenstra ISpruijt LElmslie FThiruchelvam TBacino CALangston CLupski JRSen PPopek EStankiewicz P (2016 May). Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins. Human genetics. Nogales ADeDiego MLTopham DJMartínez-Sobrido L (2016 Apr 27). Rearrangement of influenza virus spliced segments for the development of live attenuated vaccines. Journal of virology. Yang HBaker SFGonzález METopham DJMartínez-Sobrido LZand MHolden-Wiltse JWu H (2016). An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein. Journal of biopharmaceutical statistics. Anderson CSDeDiego MLTopham DJThakar J (2016). Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection. Computational and mathematical methods in medicine. Anderson CSDeDiego MLThakar JTopham DJ (2016). Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates. PloS one. Scheible KMEmo JYang HHolden-Wiltse JStraw AHuyck HMisra STopham DJRyan RMReynolds AMMariani TJPryhuber GS (2015 Dec). Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants. Clinical immunology (Orlando, Fla.). Lim KHyun YMLambert-Emo KTopham DJKim M (2015 Nov). Visualization of integrin Mac-1 in vivo. Journal of immunological methods. Halliley JLKhurana SKrammer FFitzgerald TCoyle EMChung KYBaker SFYang HMartínez-Sobrido LTreanor JJSubbarao KGolding HTopham DJSangster MY (2015 Oct 15). High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine. The Journal of infectious diseases. Rangel-Moreno Jde la Luz Garcia-Hernandez MRamos-Payan RBiear JHernady ESangster MYRandall TDJohnston CJFinkelstein JNWilliams JP (2015 Oct). Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function. Radiation research. Lim KHyun YMLambert-Emo KCapece TBae SMiller RTopham DJKim M (2015 Sep 4). Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways. Science (New York, N.Y.). Boule LAWinans BLambert KVorderstrasse BATopham DJPavelka MSLawrence BP (2015 Aug 1). Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection. American journal of physiology. Lung cellular and molecular physiology. Baker SFNogales ASantiago FWTopham DJMartínez-Sobrido L (2015 Jul 9). Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA). Vaccine. Misra RSShah SFowell DJWang HScheible KMisra SKHuyck HWyman CPRyan RMReynolds AMMariani TJKatzman PJPryhuber GS (2015 May). Preterm cord blood CD4⁺ T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4⁺ T cells in bronchopulmonary dysplasia. Human immunology. Lee AJDas SRWang WFitzgerald TPickett BEAevermann BDTopham DJFalsey ARScheuermann RH (2015 May). Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans. Journal of virology. Wu HMiao HXue HTopham DJZand M (2015 May 1). Quantifying Immune Response to Influenza Virus Infection via Multivariate Nonlinear ODE Models with Partially Observed State Variables and Time-Varying Parameters. Statistics in biosciences. Maitre NLBallard RAEllenberg JHDavis SDGreenberg JMHamvas APryhuber GS (2015 May). Respiratory consequences of prematurity: evolution of a diagnosis and development of a comprehensive approach. Journal of perinatology : official journal of the California Perinatal Association. Tankam PHe ZChu YJWon JCanavesi CLepine THindman HBTopham DJGain PThuret GRolland JP (2015 Mar 15). Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases. Optics letters. Sundararajan ASangster MYFrey SAtmar RLChen WHFerreira JBargatze RMendelman PMTreanor JJTopham DJ (2015 Jan 15). Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine. Vaccine. Pryhuber GSMaitre NLBallard RACifelli DDavis SDEllenberg JHGreenberg JMKemp JMariani TJPanitch HRen CShaw PTaussig LMHamvas A (2015). Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States. BMC pediatrics. Ramon SBaker SFSahler JMKim NFeldsott EASerhan CNMartínez-Sobrido LTopham DJPhipps RP (2014 Dec 15). The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? Journal of immunology (Baltimore, Md. : 1950). Babu TMLevine MFitzgerald TLuke CSangster MYJin HTopham DKatz JTreanor JSubbarao K (2014 Nov 28). Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine. Vaccine. Guo HBaker SFMartínez-Sobrido LTopham DJ (2014 Oct). Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus. Journal of virology. Nogales ABaker SFOrtiz-Riaño EDewhurst STopham DJMartínez-Sobrido L (2014 Sep). Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development. Journal of virology. Baker SFNogales AFinch CTuffy KMDomm WPerez DRTopham DJMartínez-Sobrido L (2014 Sep). Influenza A and B virus intertypic reassortment through compatible viral packaging signals. Journal of virology. Miao HSangster MYLivingstone AMHilchey SPZhang LTopham DJMosmann TRHolden-Wiltse JPerelson ASWu HZand MS (2014). Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection. PloS one. Alam SKnowlden ZASangster MYSant AJ (2014 Jan). CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. Journal of virology. Berry CMPenhale WJSangster MY (2014). Passive broad-spectrum influenza immunoprophylaxis. Influenza research and treatment. Chen JPompano RRSantiago FWMaillat LSciammas RSun THan HTopham DJChong ASCollier JH (2013 Nov). The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. Biomaterials. Overstreet MGGaylo AAngermann BRHughson AHyun YMLambert KAcharya MBillroth-Maclurg ACRosenberg AFTopham DJYagita HKim MLacy-Hulbert AMeier-Schellersheim MFowell DJ (2013 Sep). Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV. Nature immunology. Fouchier RAKawaoka YCardona CCompans RWGarcía-Sastre AGovorkova EAGuan YHerfst SOrenstein WAPeiris JSPerez DRRicht JARussell CSchultz-Cherry SLSmith DJSteel JTompkins SMTopham DJTreanor JJTripp RAWebby RJWebster RG (2013 Aug 9). Gain-of-function experiments on H7N9. Science (New York, N.Y.). Fouchier RAKawaoka YCardona CCompans RWFouchier RAGarcía-Sastre AGovorkova EAGuan YHerfst SKawaoka YOrenstein WAPeiris JSPerez DRRicht JARussell CSchultz-Cherry SLSmith DJSteel JTompkins SMTopham DJTreanor JJTripp RAWebby RJWebster RG (2013 Aug 8). Avian flu: Gain-of-function experiments on H7N9. Nature. Fouchier RAKawaoka YCardona CCompans RWGarcía-Sastre AGovorkova EAGuan YHerfst SOrenstein WAPeiris JSPerez DRRicht JARussell CSchultz-Cherry SLSmith DJSteel JTompkins SMTopham DJTreanor JJTripp RAWebby RJWebster RG (2013 Aug 7). Gain-of-Function Experiments on H7N9. Science (New York, N.Y.). Baker SFGuo HAlbrecht RAGarcía-Sastre ATopham DJMartínez-Sobrido L (2013 Aug). Protection against lethal influenza with a viral mimic. Journal of virology. Sangster MYBaer JSantiago FWFitzgerald TIlyushina NASundararajan AHenn ADKrammer FYang HLuke CJZand MSWright PFTreanor JJTopham DJSubbarao K (2013 Jun). B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination. Clinical and vaccine immunology : CVI. He XSSasaki SBaer JKhurana SGolding HTreanor JJTopham DJSangster MYJin HDekker CLSubbarao KGreenberg HB (2013 Jan 15). Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccine. The Journal of infectious diseases. Yang HTopham DJHolden-Wiltse JWu H (2013). Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays. Journal of biopharmaceutical statistics. Scheible KSecor-Socha SWightman TWang HMariani TJTopham DJPryhuber GQuataert S (2012 Nov). Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection. Cytometry. Part A : the journal of the International Society for Analytical Cytology. van Helden MJvan Kooten PJBekker CPGröne ATopham DJEaston AJBoog CJBusch DHZaiss DMSijts AJ (2012 Oct 5). Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice. Vaccine. van Helden MJde Graaf NBoog CJTopham DJZaiss DMSijts AJ (2012 Sep 1). The bone marrow functions as the central site of proliferation for long-lived NK cells. Journal of immunology (Baltimore, Md. : 1950). Chapman LMAggrey AAField DJSrivastava KTure SYui KTopham DJBaldwin WMMorrell CN (2012 Jul 15). Platelets present antigen in the context of MHC class I. Journal of immunology (Baltimore, Md. : 1950). Li XMiao HHenn ATopham DJWu HZand MSMosmann TR (2012 Jun 29). Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination. Vaccine. Santiago FWLambert Emo KFitzgerald TTreanor JJTopham DJ (2012 Jun 29). Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systems. Vaccine. Sundararajan AHuan LRichards KAMarcelin GAlam SJoo HYang HWebby RJTopham DJSant AJSangster MY (2012). Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization. PloS one. Guo HTopham DJ (2012). Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice. PloS one. Sharma SSundararajan ASuryawanshi AKumar NVeiga-Parga TKuchroo VKThomas PGSangster MYRouse BT (2011 Nov 22). T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proceedings of the National Academy of Sciences of the United States of America. Santiago FWFitzgerald TTreanor JJTopham DJ (2011 Nov 8). Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virus. Vaccine. Wu HKumar AMiao HHolden-Wiltse JMosmann TRLivingstone AMBelz GTPerelson ASZand MSTopham DJ (2011 Nov 1). Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors. Journal of immunology (Baltimore, Md. : 1950). Su XSangster MYD'Souza DH (2011 Nov). Time-dependent effects of pomegranate juice and pomegranate polyphenols on foodborne viral reduction. Foodborne pathogens and disease. de Graaf Nvan Helden MJTextoris-Taube KChiba TTopham DJKloetzel PMZaiss DMSijts AJ (2011 Apr). PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. European journal of immunology. Scheible KZhang GBaer JAzadniv MLambert KPryhuber GTreanor JJTopham DJ (2011 Mar 3). CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses. Vaccine. Mace CRTopham DJMosmann TRQuataert SATreanor JJMiller BL (2011 Jan 15). Label-free, arrayed sensing of immune response to influenza antigens. Talanta. Azadniv MBowers WJTopham DJCrispe IN (2011). CD4+ T cell effects on CD8+ T cell location defined using bioluminescence. PloS one. Guo HSantiago FLambert KTakimoto TTopham DJ (2011 Jan). T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model. Journal of virology. Chapman TJLambert KTopham DJ (2011). Rapid reactivation of extralymphoid CD4 T cells during secondary infection. PloS one. Su XSangster MYD'Souza DH (2010 Dec). In vitro effects of pomegranate juice and pomegranate polyphenols on foodborne viral surrogates. Foodborne pathogens and disease. Richards KATopham DChaves FASant AJ (2010 Nov 1). Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus. Journal of immunology (Baltimore, Md. : 1950). Sundararajan AGanapathy RHuan LDunlap JRWebby RJKotwal GJSangster MY (2010 Oct). Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antiviral research. Guo HTopham DJ (2010 Aug). Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection. Journal of virology. Miao HHollenbaugh JAZand MSHolden-Wiltse JMosmann TRPerelson ASWu HTopham DJ (2010 Jul). Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus. Journal of virology. Desmet EAHollenbaugh JASime PJWright TWTopham DJSant AJTakimoto TDewhurst SMaggirwar SB (2010 May 10). Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. Chapman TJTopham DJ (2010 Apr 1). Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. Journal of immunology (Baltimore, Md. : 1950). Joo HMHe YSundararajan AHuan LSangster MY (2010 Mar 2). Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination. Vaccine. Bernard MPBancos SChapman TJRyan EPTreanor JJRose RCTopham DJPhipps RP (2010 Feb 3). Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine. Baer JSantiago FYang HWu HHolden-Wiltse JTreanor JTopham DJ (2010 Jan 22). B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Vaccine. Li ZWang HXue LShin DMRoopenian DXu WQi CFSangster MYOrihuela CJTuomanen ERehg JECui XZhang QMorse HCMorris SW (2009 Nov 5). Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood. Lee HYTopham DJPark SYHollenbaugh JTreanor JMosmann TRJin XWard BMMiao HHolden-Wiltse JPerelson ASZand MWu H (2009 Jul). Simulation and prediction of the adaptive immune response to influenza A virus infection. Journal of virology. Elphick GFSarangi PPHyun YMHollenbaugh JAAyala ABiffl WLChung HLRezaie ARMcGrath JLTopham DJReichner JSKim M (2009 Apr 23). Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. Zeng JJoo HMRajini BWrammert JPSangster MYOnami TM (2009 Apr 15). The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice. Journal of immunology (Baltimore, Md. : 1950). Crompton PDMircetic MWeiss GBaughman AHuang CYTopham DJTreanor JJSanz ILee FEDurbin APMiura KNarum DLEllis RDMalkin EMullen GEMiller LHMartin LBPierce SK (2009 Mar 1). The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals. Journal of immunology (Baltimore, Md. : 1950). Lin GHSedgmen BJMoraes TJSnell LMTopham DJWatts TH (2009 Jan 15). Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease. Journal of immunology (Baltimore, Md. : 1950). Kyu SYKobie JYang HZand MSTopham DJQuataert SASanz ILee FE (2009 Jan 1). Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells. Journal of immunological methods. Bancos SBernard MPTopham DJPhipps RP (2009). Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cellular immunology. Joo HMHe YSangster MY (2008 Mar 4). Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia. Proceedings of the National Academy of Sciences of the United States of America. Klein ICornejo JCPolakos NKJohn BWuensch SATopham DJPierce RHCrispe IN (2007 Dec 1). Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood. Borowski ABBoesteanu ACMueller YMCarafides CTopham DJAltman JDJennings SRKatsikis PD (2007 Nov 15). Memory CD8+ T cells require CD28 costimulation. Journal of immunology (Baltimore, Md. : 1950). Richter MVTopham DJ (2007 Oct 15). The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection. Journal of immunology (Baltimore, Md. : 1950). Richards KAChaves FAKrafcik FRTopham DJLazarski CASant AJ (2007 Jul). Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin. Journal of virology. Polakos NKKlein IRichter MVZaiss DMGiannandrea MCrispe INTopham DJ (2007 Jul 1). Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Journal of immunology (Baltimore, Md. : 1950). Richter MRay SJChapman TJAustin SJRebhahn JMosmann TRGardner HKotelianski VdeFougerolles ARTopham DJ (2007 Apr 1). Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection. Journal of immunology (Baltimore, Md. : 1950). Vanitha DJJoo HMRouse BTSangster MY (2007 Mar 30). Quantitative analysis of herpes simplex virus type 1-specific memory B cells generated by different routes of infection. Virology. Treanor JWu HLiang HTopham DJ (2006 Nov 17). Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Vaccine. Kessels HWSchepers Kvan den Boom MDTopham DJSchumacher TN (2006 Jul 15). Generation of T cell help through a MHC class I-restricted TCR. Journal of immunology (Baltimore, Md. : 1950). Li XVanitha DJJoo HMHe YRouse BTSangster MY (2006 Jun 30). A strategy for selective, CD4+ T cell-independent activation of virus-specific memory B cells for limiting dilution analysis. Journal of immunological methods. Polakos NKCornejo JCMurray DAWright KOTreanor JJCrispe INTopham DJPierce RH (2006 Apr). Kupffer cell-dependent hepatitis occurs during influenza infection. The American journal of pathology. Topham DJChapman TJRichter M (2006 Mar). Lymphoid and extralymphoid CD4 T cells that orchestrate the antiviral immune response. Expert review of clinical immunology. Divekar AAZaiss DMLee FELiu DTopham DJSijts AJMosmann TR (2006 Feb 1). Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells. Journal of immunology (Baltimore, Md. : 1950). Chapman TJCastrucci MRPadrick RCBradley LMTopham DJ (2005 Sep 30). Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection. Virology. Lipatov ASAndreansky SWebby RJHulse DJRehg JEKrauss SPerez DRDoherty PCWebster RGSangster MY (2005 Apr). Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. The Journal of general virology. Aronica MASwaidani SZhang YHMitchell DMora ALMcCarthy SO'Neal JTopham DSheller JRBoothby M (2004 Dec). Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells. The Journal of allergy and clinical immunology. Ray SJFranki SNPierce RHDimitrova SKoteliansky VSprague AGDoherty PCde Fougerolles ARTopham DJ (2004 Feb). The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity. Sangster MYRiberdy JMGonzalez MTopham DJBaumgarth NDoherty PC (2003 Oct 6). An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. The Journal of experimental medicine. Topham DJCrispe IN (2003 May). Contrasting urban and rural lifestyles of memory CD8+ T cells. Immunity. Topham DJCastrucci MRWingo FSBelz GTDoherty PC (2001 Dec 15). The role of antigen in the localization of naive, acutely activated, and memory CD8(+) T cells to the lung during influenza pneumonia. Journal of immunology (Baltimore, Md. : 1950). Topham DJCardin RCChristensen JPBrooks JWBelz GTDoherty PC (2001 Aug). Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity. The Journal of general virology. Marshall DRTurner SJBelz GTWingo SAndreansky SSangster MYRiberdy JMLiu TTan MDoherty PC (2001 May 22). Measuring the diaspora for virus-specific CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. Doherty PCChristensen JPBelz GTStevenson PGSangster MY (2001 Apr 29). Dissecting the host response to a gamma-herpesvirus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. Wang DFeng JWen RMarine JCSangster MYParganas EHoffmeyer AJackson CWCleveland JLMurray PJIhle JN (2000 Jul). Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity. Sangster MYTopham DJD'Costa SCardin RDMarion TNMyers LKDoherty PC (2000 Feb 15). Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus. Journal of immunology (Baltimore, Md. : 1950). Marshall DSealy RSangster MColeclough C (1999 Nov 1). TH cells primed during influenza virus infection provide help for qualitatively distinct antibody responses to subsequent immunization. Journal of immunology (Baltimore, Md. : 1950). Marine JCTopham DJMcKay CWang DParganas EStravopodis DYoshimura AIhle JN (1999 Sep 3). SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. Marine JCMcKay CWang DTopham DJParganas ENakajima HPendeville HYasukawa HSasaki AYoshimura AIhle JN (1999 Sep 3). SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. Moriggl RSexl VPiekorz RTopham DIhle JN (1999 Aug). Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity. Urosevic NSilvia OJSangster MYMansfield JPHodgetts SIShellam GR (1999 Apr). Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice. The Journal of general virology. Moriggl RTopham DJTeglund SSexl VMcKay CWang DHoffmeyer Avan Deursen JSangster MYBunting KDGrosveld GCIhle JN (1999 Feb). Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. Moriggl RMarine JCTopham DJTeglund SSexl VMcKay CPiekorz RWang DParganas EYoshimura AIhle JN (1999). Differential roles of cytokine signaling during T-cell development. Cold Spring Harbor symposia on quantitative biology. Brown MPTopham DJSangster MYZhao JFlynn KJSurman SLWoodland DLDoherty PCFarr AGPattengale PKBrenner MK (1998 Nov). Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice. Nature medicine. Topham DJDoherty PC (1998 Nov 1). Longitudinal analysis of the acute Sendai virus-specific CD4+ T cell response and memory. Journal of immunology (Baltimore, Md. : 1950). Bunting KDGalipeau JTopham DBenaim ESorrentino BP (1998 Oct 1). Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice. Blood. Parganas EWang DStravopodis DTopham DJMarine JCTeglund SVanin EFBodner SColamonici ORvan Deursen JMGrosveld GIhle JN (1998 May 1). Jak2 is essential for signaling through a variety of cytokine receptors. Cell. Shellam GRSangster MYUrosevic N (1998 Apr). Genetic control of host resistance to flavivirus infection in animals. Revue scientifique et technique (International Office of Epizootics). Bunting KDSangster MYIhle JNSorrentino BP (1998 Jan). Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nature medicine. Sangster MYMackenzie JSShellam GR (1998). Genetically determined resistance to flavivirus infection in wild Mus musculus domesticus and other taxonomic groups in the genus Mus. Archives of virology. Topham DJDoherty PC (1998 Jan). Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells. Journal of virology. Doherty PCHamilton-Easton AMTopham DJRiberdy JBrooks JWCardin RD (1997 Dec). Consequences of viral infections for lymphocyte compartmentalization and homeostasis. Seminars in immunology. Topham DJTripp RADoherty PC (1997 Dec 1). CD8+ T cells clear influenza virus by perforin or Fas-dependent processes. Journal of immunology (Baltimore, Md. : 1950). Doherty PCTopham DJTripp RACardin RDBrooks JWStevenson PG (1997 Oct). Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections. Immunological reviews. Walker WSCastrucci MRSangster MYCarson RTKawaoka Y (1997 Sep 15). HEL-Flu: an influenza virus containing the hen egg lysozyme epitope recognized by CD4+ T cells from mice transgenic for an alphabeta TCR. Journal of immunology (Baltimore, Md. : 1950). Sangster MYMo XYSealy RColeclough C (1997 Aug 15). Matching antibody class with pathogen type and portal of entry: cognate mechanisms regulate local isotype expression patterns in lymph nodes draining the respiratory tract of mice inoculated with respiratory viruses, according to virus replication competence and site of inoculation. Journal of immunology (Baltimore, Md. : 1950). Tripp RATopham DJWatson SRDoherty PC (1997 Apr 15). Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking. Journal of immunology (Baltimore, Md. : 1950). Hurwitz JLSoike KFSangster MYPortner ASealy REDawson DHColeclough C (1997 Apr). Intranasal Sendai virus vaccine protects African green monkeys from infection with human parainfluenza virus-type one. Vaccine. Mo XYTripp RASangster MYDoherty PC (1997 Mar). The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon. Journal of virology. Mo XYSangster MYTripp RADoherty PC (1997 Mar). Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene. Journal of virology. Topham DJTripp RAHamilton-Easton AMSarawar SRDoherty PC (1996 Oct 1). Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig. Journal of immunology (Baltimore, Md. : 1950). Thierfelder WEvan Deursen JMYamamoto KTripp RASarawar SRCarson RTSangster MYVignali DADoherty PCGrosveld GCIhle JN (1996 Jul 11). Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. Bright JJTopham DJNag BLodge PASriram S (1996 Jul). Vaccination with peptides from MHC class II beta chain hypervariable region causes allele-specific suppression of EAE. Journal of neuroimmunology. Hall RABrand TNLobigs MSangster MYHoward MJMackenzie JS (1996 Jun). Protective immune responses to the E and NS1 proteins of Murray Valley encephalitis virus in hybrids of flavivirus-resistant mice. The Journal of general virology. Shimoda Kvan Deursen JSangster MYSarawar SRCarson RTTripp RAChu CQuelle FWNosaka TVignali DADoherty PCGrosveld GPaul WEIhle JN (1996 Apr 18). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. Doherty PCTopham DJTripp RA (1996 Apr). Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory. Immunological reviews. Topham DJTripp RASarawar SRSangster MYDoherty PC (1996 Feb). Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium. Journal of virology. Sangster MSmith FSColeclough CHurwitz JL (1995 Sep 10). Human parainfluenza virus type 1 immunization of infant mice protects from subsequent Sendai virus infection. Virology. Mo XYSangster MSarawar SColeclough CDoherty PC (1995 Sep). Differential antigen burden modulates the gamma interferon but not the immunoglobulin response in mice that vary in susceptibility to Sendai virus pneumonia. Journal of virology. Fabry ZTopham DJFee DHerlein JCarlino JAHart MNSriram S (1995 Jul 1). TGF-beta 2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo. Journal of immunology (Baltimore, Md. : 1950). Ewing CTopham DJDoherty PC (1995 Jun 20). Prevalence and activation phenotype of Sendai virus-specific CD4+ T cells. Virology. Sangster MHyland LSealy RColeclough C (1995 Feb 20). Distinctive kinetics of the antibody-forming cell response to Sendai virus infection of mice in different anatomical compartments. Virology. Hyland LSangster MSealy RColeclough C (1994 Sep). Respiratory virus infection of mice provokes a permanent humoral immune response. Journal of virology. Topham DJNag BArimilli SSriram S (1994 Aug 16). A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. Sarawar SRSangster MCoffman RLDoherty PC (1994 Aug 1). Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype. Journal of immunology (Baltimore, Md. : 1950). Sangster MYUrosevic NMansfield JPMackenzie JSShellam GR (1994 Jan). Mapping the Flv locus controlling resistance to flaviviruses on mouse chromosome 5. Journal of virology. Sangster MYHeliams DBMacKenzie JSShellam GR (1993 Jan). Genetic studies of flavivirus resistance in inbred strains derived from wild mice: evidence for a new resistance allele at the flavivirus resistance locus (Flv). Journal of virology. Weaver DSkinner SWalker LSangster M (1991 Aug). Phenotypic inhibition of the renin-angiotensin system, emergence of the Ren-2 gene, and adaptive radiation of mice. General and comparative endocrinology. Sriram STopham DJCarroll LShenoy MAdesina ACraighead JE (1991 Jul). In vivo administration of TNF-alpha prevents EMC-M virus induced viral encephalitis. International immunology. Topham DJAdesina AShenoy MCraighead JESriram S (1991 Jun). Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus. Journal of virology. Sriram STopham DJHuang SKRodriguez M (1989 Oct). Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies. Journal of virology. Sriram STopham DJCarroll L (1987 Sep 1). Haplotype-specific suppression of experimental allergic encephalomyelitis with anti-IA antibodies. Journal of immunology (Baltimore, Md. : 1950). Sangster MYShellam GR (1986). Genetically controlled resistance to flaviviruses within the house mouse complex of species. Current topics in microbiology and immunology.