Transfusion immunomodulation—transfusions alter the recipient’s immune system by down regulating cellular immunity, some innate immune functions, yet paradoxically contributing to inappropriate inflammation.
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Importance of the ABO Blood Group in Transfusion
The importance of the ABO blood group in transfusion—it seems strange that almost 120 years after the discovery of this most important blood group for transfusion and transplantation one should be discussing its importance. But tradition has it that small amounts of incompatible plasma or cells are not all that important.
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Potential Contribution of 0.9% NaCl To Adverse Effects In Patients
Crystalloid solutions are ubiquitously employed for volume resuscitation and administration of blood transfusions, and the solution of choice has been normal saline (0.9% NaCl). Normal saline is the favorite of internists and pediatricians, but surgeons and anesthesiologists in particular have always been partial to more physiologic solutions such as Ringer’s Lactate and Plasma-Lyte A.
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