Welcome to the Chakkalakal Lab
Dr. Joe Chakkalakal is a Dean’s Associate Professor in the Department of Pharmacology and Physiology affiliated with the Wilmot Cancer Center at the University Rochester Medical Center. His laboratory is interested in the contribution of stem cells to the maturation, regeneration, and lifelong maintenance of skeletal muscle in various contexts including juvenile growth, aging, and cancer survivorship.
Through the use of conditional genetic strategies Dr. Chakkalakal’s lab has uncovered niche derived signals responsible for the age-related decline of skeletal muscle resident stem cells. More recently, the Chakkalakal lab has found resident stem cell loss or gain is associated with earlier onset or attenuation of age-related skeletal muscle decline respectively. Dr. Chakkalakal’s lab is interested in building on these observations to:
- Uncover how resident stem cell manipulation affects specific aspects of skeletal muscle biology in models of post-natal maturation, aging, accelerated aging and cancer survivorship
- Identify therapies that promote resident stem cell maintenance and function