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Ciucci Lab

Welcome to the Ciucci Lab

T lymphocytes are critical players in the immune responses to autoimmune diseases, infections and tumors. During infection, T cells are needed to eliminate or restrain pathogens and for the development of immune memory that prevents reinfection. In addition, T cells can recognize malignant cells and directly mediate tumor rejection. Therefore, T cells are the focus of most cancer immunotherapy efforts, including T cell transfer and checkpoint inhibitor therapies. However, the heterogeneity of T cell responses to both tumor and pathogens and their versatility overtime have limited our ability to manipulate them in patients.
To tackle this problem, we are studying T cell repertoire formation and its response to infection and tumors at the single-cell resolution.
Results from this research aim at identifying novel T cell subpopulations that could be used in patients as diagnostic or prognostic tools to tailored therapeutic intervention. In addition, given the critical role of T cells in immunity, investigating their diversity, differentiation and function is expected to facilitate the design of cancer immunotherapy strategies and the treatment or prevention of infectious and autoimmune diseases.

Thomas Ciucci, Ph.D.

Thomas Ciucci, Ph.D.
Principal Investigator

Projects

Tumor Immunology Thumb

Tumor Immunology

Vaccine and Infectious Disease Thumb

Vaccine and Infectious Diseases

T Cell Transcriptome Thumb

T Cell Transcriptome and Epigenome

T Cell Repertoire Thumb

T Cell Repertoire Engagement

View All Projects

Publications

View All Publications

Contact Us

  Ciucci Lab
601 Elmwood Ave
KMRB 3-9643
Rochester, NY 14642