Associations with development of familial dysbetalipoproteinemia (FD)
Why not all subjects with the ε2ε2 genotype of the common polymorphism of apolipoprotein E (APOE) go on to develop Type III hyperlipidemia (FD) despite a strong association with the genotype is not known. We hypothesized that three understudied factors would play a significant role in FD development in ε2ε2 subjects. These factors were apolipoprotein E (apoE), compositional features of high-density lipoprotein (HDL) particles, and insulin resistance. This hypothesis will be tested using multivariable logistic regression modeling in the Prevention of Renal and Vascular Endstage Disease (PREVEND) study from the Netherlands.
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