URMC / Labs / Dewhurst Lab / Publications Publications Piekna-Przybylska DBambara RABalakrishnan L (2016 Apr 22). Acetylation regulates DNA repair mechanisms in human cells. Cell cycle (Georgetown, Tex.). Blanchard CBrooks LBeckley AColquhoun JDewhurst SDunman PM (2016 Feb). Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments. Antimicrobial agents and chemotherapy. Nishimura CPolesskaya ODewhurst SSilva JN (2016). Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation. Journal of visualized experiments : JoVE. Puccini JMMarker DFFitzgerald TBarbieri JKim CSMiller-Rhodes PLu SMDewhurst SGelbard HA (2015 Apr 1). Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. Cox ABaker SFNogales AMartínez-Sobrido LDewhurst S (2015 Mar). Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine. Journal of virology. Cox ADewhurst S (2015). A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy. Journal of virology. Ying BTollefson AESpencer JFBalakrishnan LDewhurst SCapella CBuller RMToth KWold WS (2014 Dec). Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters. Antimicrobial agents and chemotherapy. Silva JNPolesskaya OWei HSRasheed IYChamberlain JMNishimura CFeng CDewhurst S (2014 Oct). Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation (New York, N.Y. : 1994). Nogales ABaker SFOrtiz-Riaño EDewhurst STopham DJMartínez-Sobrido L (2014 Sep). Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development. Journal of virology. Polesskaya OWong CLebron LChamberlain JMGelbard HAGoodfellow VKim MDaiss JLDewhurst S (2014 Apr). MLK3 regulates fMLP-stimulated neutrophil motility. Molecular immunology. Domm WBrewer MBaker SFFeng CMartínez-Sobrido LTreanor JDewhurst S (2014 Mar). Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies. Journal of virological methods. Lewis CADewhurst SMcMahon JMBunce CAKeefer MCAlio AP (2014). Theoretical model of critical issues in informed consent in HIV vaccine trials. AIDS care. Lin FRoiland RPolesskaya OChapman BJohnson MBrasch JChen DGMapstone M (2013 Dec 7). Fatigability Disrupts Cognitive Processes' Regulation of Inflammatory Reactivity in Old Age. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. Rhoo KHGranger MSur JFeng CGelbard HADewhurst SPolesskaya O (2014). Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model. PloS one. Goodfellow VSLoweth CJRavula SBWiemann TNguyen TXu YTodd DESheppard DPollack SPolesskaya OMarker DFDewhurst SGelbard HA (2013 Oct 24). Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. Journal of medicinal chemistry. Easterhoff DDiMaio JTLiyanage WLo CWBae WDoran TMSmrcka ANilsson BLDewhurst S (2013 Sep 15). Fluorescence detection of cationic amyloid fibrils in human semen. Bioorganic & medicinal chemistry letters. Lu NSilva JGu YGerber SWu HGelbard HDewhurst SMiao H (2013 Jul 1). Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images. Pattern recognition. Marker DFTremblay MÈPuccini JMBarbieri JGantz Marker MALoweth CJMuly ECLu SMGoodfellow VSDewhurst SGelbard HA (2013 Jun 12). The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. Arany SBenoit DSDewhurst SOvitt CE (2013 Jun). Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. Ma QGelbard HAMaggirwar SBDewhurst SGendelman HEPeterson DRDiFrancesco RHochreiter JSMorse GDSchifitto G (2013 Jun). Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients. Journal of neurovirology. Easterhoff DOntiveros FBrooks LRKim YRoss BSilva JNOlsen JSFeng CHardy DJDunman PMDewhurst S (2013 Jun). Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen. Antimicrobial agents and chemotherapy. Sullivan MABrooks LRWeidenborner PDomm WMattiacio JXu QTiberio MWentworth TKobie JBryk PZheng BMurphy MSanz IDewhurst S (2013 Mar 12). Anti-idiotypic monobodies derived from a fibronectin scaffold. Biochemistry. Mapstone MHilton TNYang HGuido JJLuque AEHall WJDewhurst SShah K (2013). Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging and disease. Alcéna DCKobie JJKaminski DARosenberg AFMattiacio JLBrewer MDewhurst SDykes CJin XKeefer MCSanz I (2013). 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles. PloS one. Capella CBeltejar MJBrown CFong VDaddacha WKim BDewhurst S (2012 Oct). Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase. Journal of virology. Arany SXu QHernady EBenoit DSDewhurst SOvitt CE (2012 Jun). Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. Journal of cellular biochemistry. Olsen JSDiMaio JTDoran TMBrown CNilsson BLDewhurst S (2012 Apr 6). Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide. The Journal of biological chemistry. Polesskaya OSun ASalahura GSilva JNDewhurst SKasischke K (2012). Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence. Journal of visualized experiments : JoVE. Kobie JJAlcena DCZheng BBryk PMattiacio JLBrewer MLabranche CYoung FMDewhurst SMontefiori DCRosenberg AFFeng CJin XKeefer MCSanz I (2012). 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. PloS one. Silva JPolesskaya OKnight WZheng JTGranger MLopez TOntiveros FFeng CYan CKasischke KADewhurst S (2012). Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. Journal of neuroinflammation. Olsen JSEasterhoff DDewhurst S (2011 Dec). Advances in HIV microbicide development. Future medicinal chemistry. Aggarwal SDewhurst STakimoto TKim B (2011 Oct 7). Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex. The Journal of biological chemistry. Hazard MSteele SWang DPearson TScheideler MDewhurst S (2011 Oct). CTSA-IP: a solution to identifying and aggregating intellectual property across the NIH Clinical Translational Science Award (CTSA) consortium of biomedical research institutes. Clinical and translational science. Domm WBrooks LChung HLFeng CBowers WJWatson GMcGrath JLDewhurst S (2011 Sep 16). Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier. Vaccine. Bussey KADesmet EAMattiacio JLHamilton ABradel-Tretheway BBussey HEKim BDewhurst STakimoto T (2011 Jul). PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. Journal of virology. Caserta MTDewhurst S (2011 May 12). Dazed and confused by HHV-6. Blood. Mattiacio JWalter SBrewer MDomm WFriedman AEDewhurst S (2011 Mar 21). Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env. Vaccine. Easterhoff DDiMaio JTDoran TMDewhurst SNilsson BL (2011 Mar 2). Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides. Biophysical journal. Polesskaya OSilva JSanfilippo CDesrosiers TSun AShen JFeng CPolesskiy ADeane RZlokovic BKasischke KDewhurst S (2011 Feb 10). Methamphetamine causes sustained depression in cerebral blood flow. Brain research. Lu SMTremblay MÈKing ILQi JReynolds HMMarker DFVarrone JJMajewska AKDewhurst SGelbard HA (2011). HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PloS one. Fong VOsterbur MCapella CKim YEHine CGorbunova VSeluanov ADewhurst S (2011). Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PloS one. Polesskaya OCunningham LLFrancis SPLuebke AEZhu XCollins DVasilyeva ONSahler JDesmet EAGelbard HAMaggirwar SBWalton JPFrisina RDDewhurst S (2010 Dec 1). Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing research. Olsen JSBrown CCapule CCRubinshtein MDoran TMSrivastava RKFeng CNilsson BLYang JDewhurst S (2010 Nov 12). Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection. The Journal of biological chemistry. Perry SWBarbieri JTong NPolesskaya OPudasaini SStout ALu RKiebala MMaggirwar SBGelbard HA (2010 Oct 20). Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. The Journal of neuroscience : the official journal of the Society for Neuroscience. Gelbard HADewhurst SMaggirwar SBKiebala MPolesskaya OGendelman HE (2010 Oct). Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. Gorantla SMakarov EFinke-Dwyer JGebhart CLDomm WDewhurst SGendelman HEPoluektova LY (2010 Jun 15). CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. Journal of immunology (Baltimore, Md. : 1950). Love TMThurston SWKeefer MCDewhurst SLee HY (2010 Jun). Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences. Journal of virology. Desmet EAHollenbaugh JASime PJWright TWTopham DJSant AJTakimoto TDewhurst SMaggirwar SB (2010 May 10). Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. Eggert DDash PKGorantla SDou HSchifitto GMaggirwar SBDewhurst SPoluektova LGelbard HAGendelman HE (2010 Jan 15). Neuroprotective activities of CEP-1347 in models of neuroAIDS. Journal of immunology (Baltimore, Md. : 1950). Aggarwal SBradel-Tretheway BTakimoto TDewhurst SKim B (2010). Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. PloS one. Kennedy EMHergott CDewhurst SKim B (2009 Dec 1). The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate. Biochemistry. Schifitto GZhong JGill DPeterson DRGaugh MDZhu TTivarus MCruttenden KMaggirwar SBGendelman HEDewhurst SGelbard HA (2009 Apr). Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment. Journal of neurovirology. Volcy KDewhurst S (2009 Feb 5). Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells. Virology. Bimber BNChugh PGiorgi EEKim BAlmudevar ALDewhurst SO'Connor DHLee HY (2009). Nef gene evolution from a single transmitted strain in acute SIV infection. Retrovirology. Bradel-Tretheway BGKelley ZChakraborty-Sett STakimoto TKim BDewhurst S (2008 Dec). The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit. The Journal of general virology. Sapinoro RVolcy KRodrigo WWSchlesinger JJDewhurst S (2008 Apr 10). Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells. Virology. Paletzki RFMyakishev MVPolesskaya OOrosz AHyman SEVinson C (2008 Apr 9). Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience. Norman JPPerry SWReynolds HMKiebala MDe Mesy Bentley KLTrejo MVolsky DJMaggirwar SBDewhurst SMasliah EGelbard HA (2008). HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PloS one. Taylor SRGonzalez-Begne MDewhurst SChimini GHiggins CFMelvin JEElliott JI (2008 Jan 1). Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. Journal of immunology (Baltimore, Md. : 1950). Chugh PBradel-Tretheway BMonteiro-Filho CMPlanelles VMaggirwar SBDewhurst SKim B (2008). Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology. Myakishev MPolesskaya OKulichkova VBaranova AGause LKonstantinova I (2008). PCR-based detection of Pol III-transcribed transposons and its application to the rodent model of ultraviolet response. Cell stress & chaperones. Sapinoro RMaguire CABurgess ADewhurst S (2007 Dec). Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors. The journal of gene medicine. Duke CMMaguire CAKeefer MCFederoff HJBowers WJDewhurst S (2007 Oct 16). HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. Santos KSanfilippo CMNarrow WCCasey AERodriguez-Colon SMMcDermott MPFederoff HJBowers WJDewhurst S (2007 Oct). Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. Journal of virological methods. Lankes HAZanghi CNSantos KCapella CDuke CMDewhurst S (2007 May). In vivo gene delivery and expression by bacteriophage lambda vectors. Journal of applied microbiology. Malboeuf CMSimon DALee YELankes HADewhurst SFrelinger JGRose RC (2007 Apr 30). Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo. Vaccine. Sui ZSniderhan LFSchifitto GPhipps RPGelbard HADewhurst SMaggirwar SB (2007 Mar 1). Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. Journal of immunology (Baltimore, Md. : 1950). Dewhurst SMaggirwar SBSchifitto GGendelman HEGelbard HA (2007 Mar). Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Gorantla SSneller HWalters LSharp JGPirruccello SJWest JTWood CDewhurst SGendelman HEPoluektova L (2007 Mar). Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. Journal of virology. Santos KDuke CMRodriguez-Colon SMDakwar AFan SKeefer MCFederoff HJFrelinger JGBowers WJDewhurst S (2007 Feb 19). Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. Chugh PFan SPlanelles VMaggirwar SBDewhurst SKim B (2007 Feb 9). Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. Journal of molecular biology. Santos KSimon DAConway EBowers WJMitra SFoster THLugade ALord EMFederoff HJDewhurst SFrelinger JG (2007 Feb). Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human gene therapy. Zanghi CNSapinoro RBradel-Tretheway BDewhurst S (2007). A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery. Nucleic acids research. Polesskaya OOSmith RFFryxell KJ (2007 Jan 1). Chronic nicotine doses down-regulate PDE4 isoforms that are targets of antidepressants in adolescent female rats. Biological psychiatry. Polesskaya OOFryxell KJMerchant ADLocklear LLKer KFMcDonald CGEppolito AKSmith LNWheeler TLSmith RF (2007 Jan). Nicotine causes age-dependent changes in gene expression in the adolescent female rat brain. Neurotoxicology and teratology. Gorantla SSneller HWalters LSharp JGPirruccello SJWest JWood CDewhurst SGendelman HEPoluektova L (2007 Jan 01). A new paradigm for studies of HIV-1 pathobiology in humanized Balb/c-Rag2-/-?c-/- mice. J. Virol. PMCID: PMC1865995 . Sui ZFan SSniderhan LReisinger ELitzburg ASchifitto GGelbard HADewhurst SMaggirwar SB (2006 Jul 1). Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation. Journal of immunology (Baltimore, Md. : 1950). Santos KDuke CMDewhurst S (2006 Jun). Amplicons as vaccine vectors. Current gene therapy. Sui ZSniderhan LFFan SKazmierczak KReisinger EKovács ADPotash MJDewhurst SGelbard HAMaggirwar SB (2006 May). Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons. The European journal of neuroscience. Hall CBCaserta MTSchnabel KCMcDermott MPLofthus GKCarnahan JAGilbert LMDewhurst S (2006 Apr 15). Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6. The Journal of infectious diseases. Polesskaya OOAston CSokolov BP (2006 Feb 15). Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1. Journal of neuroscience research. Maguire CASapinoro RGirgis NRodriguez-Colon SMRamirez SHWilliams JDewhurst S (2006 Jan 30). Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens. Vaccine. Zeng LPlanelles VSui ZGartner SMaggirwar SBDewhurst SYe LNerurkar VRYanagihara RLu Y (2006 Jan). HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1. The journal of gene medicine. Dou HEllison BBradley JKasiyanov APoluektova LYXiong HMaggirwar SDewhurst SGelbard HAGendelman HE (2005 Sep 14). Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. Zhen ZBradel-Tretheway BSumagin SBidlack JMDewhurst S (2005 Sep). The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro. Journal of virology. Liu QRWalther DDrgon TPolesskaya OLesnick TGStrain KJde Andrade MBower JHMaraganore DMUhl GR (2005 Apr 5). Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. Perry SWNorman JPLitzburg AZhang DDewhurst SGelbard HA (2005 Apr 1). HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. Journal of immunology (Baltimore, Md. : 1950). Fan SMaguire CARamirez SHBradel-Tretheway BSapinoro RSui ZChakraborty-Sett SDewhurst S (2005 Apr). Valproic acid enhances gene expression from viral gene transfer vectors. Journal of virological methods. Jin NKovács ADSui ZDewhurst SMaggirwar SB (2005 Mar). Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death. Neuropharmacology. Gorantla SSantos KMeyer VDewhurst SBowers WJFederoff HJGendelman HEPoluektova L (2005 Feb). Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. Journal of virology. Zanghi CNLankes HABradel-Tretheway BWegman JDewhurst S (2005). A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda. Nucleic acids research. Fan SRamirez SHGarcia TMDewhurst S (2004 Dec 6). Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. Brain research. Molecular brain research. Diamond TLRoshal MJamburuthugoda VKReynolds HMMerriam ARLee KYBalakrishnan MBambara RAPlanelles VDewhurst SKim B (2004 Dec 3). Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. The Journal of biological chemistry. Renda MJBradel-Tretheway BPlanelles VBambara RADewhurst S (2004 Dec). Inhibition of HIV type 1 replication using lentiviral-mediated delivery of mutant tRNA(Lys3)A58U. AIDS research and human retroviruses. Hall CBCaserta MTSchnabel KCBoettrich CMcDermott MPLofthus GKCarnahan JADewhurst S (2004 Oct). Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). The Journal of pediatrics. Caserta MTMcDermott MPDewhurst SSchnabel KCarnahan JAGilbert LLathan GLofthus GKHall CB (2004 Oct). Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. The Journal of pediatrics. Zhen ZBradel-Tretheway BGDewhurst SBidlack JM (2004 Jul 30). Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors. Journal of neuroscience methods. Ramirez SHFan SMaguire CAPerry SHardiek KRamkumar VGelbard HADewhurst SMaggirwar SB (2004 Jul 15). Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. Journal of neuroscience research. Dewhurst S (2004 Jun). Human herpesvirus type 6 and human herpesvirus type 7 infections of the central nervous system. Herpes : the journal of the IHMF. Latchney LRFallon MACulp DJGelbard HADewhurst S (2004 May). Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. Lu YLiu CZeng LLin ZDewhurst SGartner SPlanelles V (2003 Nov). Efficient gene transfer into human monocyte-derived macrophages using defective lentiviral vectors. Cellular and molecular biology (Noisy-le-Grand, France). Dou HBirusingh KFaraci JGorantla SPoluektova LYMaggirwar SBDewhurst SGelbard HAGendelman HE (2003 Oct 8). Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. Polesskaya OOHaroutunian VDavis KLHernandez ISokolov BP (2003 Oct 1). Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia. Journal of neuroscience research. Diamond TLSouroullas GWeiss KKLee KYBambara RADewhurst SKim B (2003 Aug 8). Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque. The Journal of biological chemistry. Bradel-Tretheway BGZhen ZDewhurst S (2003 Aug). Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame. Journal of virological methods. Wang XMesserle MSapinoro RSantos KHocknell PKJin XDewhurst S (2003 Jul). Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes. Journal of virology. Wang XWiley RDEvans TGBowers WJFederoff HJDewhurst S (2003 Jun 2). Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. Richards JLAbend JRMiller MLChakraborty-Sett SDewhurst SWhetter LE (2003 May). A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells. European journal of biochemistry / FEBS. Mir AAMyakishev MVPolesskaya OOMoitra JPetersen DMiller LOrosz AVinson C (2003 Apr). A search for candidate genes for lipodystrophy, obesity and diabetes via gene expression analysis of A-ZIP/F-1 mice. Genomics. Richards JMiller MAbend JKoide AKoide SDewhurst S (2003 Mar 7). Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. Journal of molecular biology. Sokolov BPPolesskaya OOUhl GR (2003 Jan). Mouse brain gene expression changes after acute and chronic amphetamine. Journal of neurochemistry. Perry SWDewhurst SBellizzi MJGelbard HA (2002 Dec). Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk? Journal of neurovirology. Hocknell PKWiley RDWang XEvans TGBowers WJHanke TFederoff HJDewhurst S (2002 Jun). Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. Journal of virology. Polesskaya OOSokolov BP (2002 Mar 15). Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. Journal of neuroscience research. Caserta MTMock DJDewhurst S (2001 Sep 15). Human herpesvirus 6. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Ramirez SHSanchez JFDimitri CAGelbard HADewhurst SMaggirwar SB (2001 Aug). Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. Journal of neurochemistry. Tong NSanchez JFMaggirwar SBRamirez SHGuo HDewhurst SGelbard HA (2001 May). Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. The European journal of neuroscience. Skrincosky DWillis RAHocknell PKFrelinger JGMirandola PWang XDewhurst S (2001). Epitope mapping of human herpesvirus-7 gp65 using monoclonal antibodies. Archives of virology. Bal HPChroboczek JSchoehn GRuigrok RWDewhurst S (2000 Oct). Adenovirus type 7 penton purification of soluble pentamers from Escherichia coli and development of an integrin-dependent gene delivery system. European journal of biochemistry / FEBS. Skrincosky DHocknell PWhetter LSecchiero PChandran BDewhurst S (2000 May). Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7. Journal of virology. Tong NPerry SWZhang QJames HJGuo HBrooks ABal HKinnear SAFine SEpstein LGDairaghi DSchall TJGendelman HEDewhurst SSharer LRGelbard HA (2000 Feb 1). Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. Journal of immunology (Baltimore, Md. : 1950). Maggirwar SBRamirez STong NGelbard HADewhurst S (2000 Feb). Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells. Journal of neurochemistry. Dewhurst SLda Cruz RLWhetter L (2000 Jan 1). Pathogenesis and treatment of HIV-1 infection: recent developments (Y2K update). Frontiers in bioscience : a journal and virtual library. Norton RACaserta MTHall CBSchnabel KHocknell PDewhurst S (1999 Nov). Detection of human herpesvirus 6 by reverse transcription-PCR. Journal of clinical microbiology. Dominguez GDambaugh TRStamey FRDewhurst SInoue NPellett PE (1999 Oct). Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. Journal of virology. Hodge Sde Rosayro JGlenn AOjukwu ICDewhurst SMcClure HMBischofberger NAnderson DCKlumpp SANovembre FJ (1999 Oct). Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj. Journal of virology. Maggirwar SBTong NRamirez SGelbard HADewhurst S (1999 Aug). HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. Journal of neurochemistry. Wilhelm KParker GDewhurst-Savellis JAsghari A (1999 Jul). Psychological predictors of single and recurrent major depressive episodes. Journal of affective disorders. Whetter LEOjukwu ICNovembre FJDewhurst S (1999 Jul). Pathogenesis of simian immunodeficiency virus infection. The Journal of general virology. Fine SMMaggirwar SBElliott PREpstein LGGelbard HADewhurst S (1999 Mar 1). Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia. Journal of neuroimmunology. Hodge SNovembre FJWhetter LGelbard HADewhurst S (1998 Dec 20). Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14. Virology. Maggirwar SBSarmiere PDDewhurst SFreeman RS (1998 Dec 15). Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. Rotola ARavaioli TGonelli ADewhurst SCassai EDi Luca D (1998 Nov 10). U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture. Proceedings of the National Academy of Sciences of the United States of America. Deng SXPanahian NJames HGelbard HAFederoff HJDewhurst SEpstein LG (1998 Sep 1). Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption. Journal of neuroscience methods. Hodge SNovembre FJDewhurst S (1998 Aug). Endogenous tumor necrosis factor-alpha contributes to lymphoproliferation induced by simian immunodeficiency virus variant, SIVsmmPBj14. Immunology letters. Perry SWHamilton JATjoelker LWDbaibo GDzenko KAEpstein LGHannun YWhittaker JSDewhurst SGelbard HA (1998 Jul 10). Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. The Journal of biological chemistry. New DRMaggirwar SBEpstein LGDewhurst SGelbard HA (1998 Jul 10). HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. The Journal of biological chemistry. Whetter LNovembre FJSaucier MGummuluru SDewhurst S (1998 Jul). Costimulatory pathways in lymphocyte proliferation induced by the simian immunodeficiency virus SIVsmmPBj14. Journal of virology. Saucier MHodge SDewhurst SGibson TGibson JPMcClure HMNovembre FJ (1998 May 10). The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages. Virology. Deng HDewhurst S (1998 Jan). Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. Journal of virology. Hall CBCaserta MTSchnabel KCLong CEpstein LGInsel RADewhurst S (1998 Jan). Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Bulboaca GHDeng HDewhurst SCalos MP (1998). Telomeric sequences from human herpesvirus 6 do not mediate nuclear retention of episomal DNA in human cells. Archives of virology. Bar-Peled OBen-Hur HBiegon AGroner YDewhurst SFuruta ARothstein JD (1997 Dec). Distribution of glutamate transporter subtypes during human brain development. Journal of neurochemistry. Dewhurst SSkrincosky Dvan Loon N (1997 Nov 18). Human herpesvirus 7. Expert reviews in molecular medicine. Dewhurst SSkrincosky Dvan Loon N (1997 Nov 5). Human herpesvirus 6. Expert reviews in molecular medicine. Walker PHitch GJDewhurst SAWhiteley HEBrandimonte MA (1997 Jul). The representation of nonstructural information in visual memory: evidence from image combination. Memory & cognition. Krajewski SJames HJRoss JBlumberg BMEpstein LGGendelman HEGummuluru SDewhurst SSharer LRReed JCGelbard HA (1997 Jun). Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis. Neuropathology and applied neurobiology. Dykes CChan HKrenitsky DMDewhurst S (1997 May). Stringent structural and sequence requirements of the human herpesvirus 6B lytic-phase origin of DNA replication. The Journal of general virology. van Loon NDykes CDeng HDominguez GNicholas JDewhurst S (1997 Apr). Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7. Journal of virology. Dewhurst SWhetter L (1997 Mar 1). Pathogenesis and treatment of HIV-1 infection: recent developments. Frontiers in bioscience : a journal and virtual library. Gummuluru SNovembre FJLewis MGelbard HADewhurst S (1996 Nov 1). Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14. Virology. Fine SMAngel RAPerry SWEpstein LGRothstein JDDewhurst SGelbard HA (1996 Jun 28). Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. The Journal of biological chemistry. Dewhurst SSander DMSgro JY (1996 Feb). Resources for HIV/AIDS on the Internet. Molecular medicine today. Gummuluru SNovembre FJSeshi BDewhurst S (1996 Jan 1). SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes. Virology. Dewhurst SGelbard HAFine SM (1996 Jan). Neuropathogenesis of AIDS. Molecular medicine today. Secchiero PNicholas JDeng HXiaopeng Tvan Loon NRuvolo VRBerneman ZNReitz MSDewhurst S (1995 Dec). Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity. Journal of virology. Dollard SCJames HJSharer LREpstein LGGelbard HADewhurst S (1995 Dec). Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis. Neuropathology and applied neurobiology. van Loon NMGummuluru SSherwood DJMarentes RHall CBDewhurst S (1995 Oct). Direct sequence analysis of human herpesvirus 6 (HHV-6) sequences from infants and comparison of HHV-6 sequences from mother/infant pairs. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Frenkel LMWagner LEDemeter LMDewhurst SCoombs RWMurante BLReichman RC (1995 May). Effects of zidovudine use during pregnancy on resistance and vertical transmission of human immunodeficiency virus type 1. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Talley AKDewhurst SPerry SWDollard SCGummuluru SFine SMNew DEpstein LGGendelman HEGelbard HA (1995 May). Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Molecular and cellular biology. Saito YSharer LRDewhurst SBlumberg BMHall CBEpstein LG (1995 Mar). Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy. Journal of neurovirology. Frenkel LMWagner LEAtwood SMCummins TJDewhurst S (1995 Feb). Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine. Journal of clinical microbiology. Dollard SCGummuluru STsang SFultz PNDewhurst S (1994 Dec). Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14. Journal of virology. Caserta MTHall CBSchnabel KMcIntyre KLong CCostanzo MDewhurst SInsel REpstein LG (1994 Dec). Neuroinvasion and persistence of human herpesvirus 6 in children. The Journal of infectious diseases. Dewhurst SKrenitsky DMDykes C (1994 Oct). Human herpesvirus 6B origin: sequence diversity, requirement for two binding sites for origin-binding protein, and enhanced replication from origin multimers. Journal of virology. Hall CBLong CESchnabel KCCaserta MTMcIntyre KMCostanzo MAKnott ADewhurst SInsel RAEpstein LG (1994 Aug 18). Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. The New England journal of medicine. Thomson BJDewhurst SGray D (1994 May). Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini. Journal of virology. Dewhurst SDollard SCPellett PEDambaugh TR (1993 Dec). Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29. Journal of virology. Krohn KJHakkarainen KAavik EDewhurst SSadaie RMullins JI (1993 Sep). Transcomplementation of simian immunodeficiency virus Rev with human T-cell leukemia virus type I Rex. Journal of virology. Dewhurst SMcIntyre KSchnabel KHall CB (1993 Feb). Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. Journal of clinical microbiology. Dewhurst SChandran BMcIntyre KSchnabel KHall CB (1992 Sep). Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants. Virology. Dewhurst SEmbretson JEFultz PNMullins JI (1992 Jun). Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14: characterization and comparison to acutely pathogenic clones. AIDS research and human retroviruses. Iglewski WJDewhurst S (1991 Jun 3). Cellular mono(ADP-ribosyl) transferase inhibits protein synthesis. FEBS letters. Dewhurst SEmbretson JEAnderson DCMullins JIFultz PN (1990 Jun 14). Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM-PBj14. Nature. Smith DBMosely RPBegent RHCoakham HBGlaser MGDewhurst SKelly ABagshawe KD (1990 Feb). Quantitative distribution of 131I-labelled monoclonal antibodies administered by the intra-ventricular route. European journal of cancer (Oxford, England : 1990). Fultz PNAnderson DCMcClure HMDewhurst SMullins JI (1990). SIVsmm infection of macaque and mangabey monkeys: correlation between in vivo and in vitro properties of different isolates. Developments in biological standardization. Mullins JIHoover EADonahue PRDewhurst SQuackenbush SLMurphey-Corb MMartin LNFultz PNGallo MVReinhart TA (1990). The FeLV and SIV AIDS pathogenesis models: search for and analysis of molecularly defined pathogens. Developments in biological standardization. Green AJDewhurst SEBegent RHBagshawe KDRiggs SJ (1990). Accurate quantification of 131I distribution by gamma camera imaging. European journal of nuclear medicine. Sakai KDewhurst SMa XYVolsky DJ (1988 Nov). Differences in cytopathogenicity and host cell range among infectious molecular clones of human immunodeficiency virus type 1 simultaneously isolated from an individual. Journal of virology. Dewhurst SSakai KZhang XHWasiak AVolsky DJ (1988 Jan). Establishment of human glial cell lines chronically infected with the human immunodeficiency virus. Virology. Dewhurst SSakai KBresser JStevenson MEvinger-Hodges MJVolsky DJ (1987 Dec). Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV. Journal of virology. Dewhurst SStevenson MVolsky DJ (1987 Mar 9). Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells. FEBS letters. Dewhurst SBresser JStevenson MSakai KEvinger-Hodges MJVolsky DJ (1987 Mar 9). Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV). FEBS letters. Dewhurst SStevenson MMcComb RDVolsky DJ (1987). Expression of glial fibrillary acidic protein in human glioma cell lines as detected by molecular hybridization. Acta neuropathologica. Smith DMDewhurst SShepherd SVolsky DJGoldsmith JC (1987 Jan). False-positive enzyme-linked immunosorbent assay reactions for antibody to human immunodeficiency virus in a population of midwestern patients with congenital bleeding disorders. Transfusion. Volsky DJSakai KStevenson MDewhurst S (1986 Dec). Retroviral etiology of the acquired immune deficiency syndrome (AIDS). AIDS research. Goldsmith JCDewhurst SHedenskog MCasareale DVolsky DJ (1986 Oct). High prevalence and high titers of LAV/HTLV-III antibodies in healthy hemophiliacs in the midwestern United States. The American journal of medicine. Hedenskog MDewhurst SLudvigsen CSinangil FRodriguez LWu YTVolsky DJ (1986 Aug). Testing for antibodies to AIDS-associated retrovirus (HTLV-III/LAV) by indirect fixed cell immunofluorescence: specificity, sensitivity, and applications. Journal of medical virology. Dewhurst SVolsky DJ (1986 Mar 13). A simple method for the production of specific antiserum to the second nuclear antigen (EBNA-2) of Epstein-Barr virus (EBV). Journal of immunological methods. Volsky DJWu YTStevenson MDewhurst SSinangil FMerino FRodriguez LGodoy G (1986 Mar 6). Antibodies to HTLV-III/LAV in Venezuelan patients with acute malarial infections. The New England journal of medicine. Volsky DJRodriguez LDewhurst SSinangil FSakai KMerino FEsparza BDe Salvo L (1986). Antibodies to acquired immune deficiency syndrome (AIDS)-associated virus (HTLV-III/LAV) in Venezuelan populations. AIDS research. Rodriquez LDewhurst SSinangil FMerino FGodoy GVolsky DJ (1985 Nov 16). Antibodies to HTLV-III/LAV among aboriginal Amazonian Indians in Venezuela. Lancet (London, England).