Cells undergoing apoptosis can release soluble cues (find-me signals) that promote the recruitment of phagocytes in the initial stages of apoptotic cell clearance. Triphosphate nucleotides (ATP and UTP), acting via P2Y receptors on phagocytes, were recently identified as such a find-me cue.
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The transition from inflammation to resolution is critical for the restoration of tissue function following injury or infection. Tissue resident macrophages (TRM) are key initiators of inflammation through the release of cytokines that recruit neutrophils and other inflammatory leukocytes to the damaged tissue. TRM also play a vital role in resolving inflammation by clearing dead cells and producing pro-resolving mediators that stimulate wound healing and restoration of tissue homeostasis.
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Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is the most prevalent lymphoid malignancy in many regions of the world including the United States (~140,000 patients). The addition of therapeutic unconjugated CD20 monoclonal antibodies (mAb) to chemotherapies that target B cell proliferation has significantly improved CLL patient outcomes and survival.
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