The development of adult tissues and organs requires the integrated interactions of multiple tissues, cell-types and processes. We hypothesize that oligosaccharides on the cell surface are crucial for orchestrating development processes because glycoconjugates are expressed in regulated temporal and spatial patterns and because they are capable of modulate cellular interactions.
Learn more about Glycosyltransferases in C. elegans Development
In developing embryos, signals sent between cells involve molecules that play regulatory roles in programming cell fate, cell adhesion and cell migration properties. Many of these molecules are posttranslationally modified with glycan chains. Recent studies have shown that the posttranslational modification process is critical in regulating cell function and in orchestrating the gene expression patterns in groups of cells or in boundaries or compartments of tissues--important events in the formation of organ systems and anatomical structures.
Learn more about Functional Genomics and Proteomics Research