URMC / Labs / Kobie Lab / Publications Publications Jaworski JPBryk PBrower ZZheng BHessell AJRosenberg AFWu TTSanz IKeefer MCHaigwood NLKobie JJ (2017). Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques. PloS one. Huang HLiu SJean MSimpson SHuang HMerkley MHayashi TKong WRodríguez-Sánchez IZhang XYosief HOMiao HQue JKobie JJBradner JSantoso NGZhang WZhu J (2017). A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association. Frontiers in microbiology. Jean MJHayashi THuang HBrennan JSimpson SPurmal AGurova KKeefer MCKobie JJSantoso NGZhu J (2017). Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation. Frontiers in microbiology. Keefer MZheng BRosenberg AFKobie JJ (2016 Sep 9). Increased steady-state memory B cell subsets among high-risk participants in an HIV vaccine trial. AIDS research and human retroviruses. Piepenbrink MSSamuel MZheng BCarter BFucile CBunce CKiebala MKhan AAThakar JMaggirwar SBMorse DRosenberg AFHaughey NJValenti WKeefer MCKobie JJ (2016). Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PloS one. Kobie JJZheng BPiepenbrink MSHessell AJHaigwood NLKeefer MCSanz I (2015 Apr). Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal Antibodies. Monoclonal antibodies in immunodiagnosis and immunotherapy. Kiebala MSingh MVPiepenbrink MSQiu XKobie JJMaggirwar SB (2015). Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. PloS one. Bobo BPhelan DRebhahn JPiepenbrink MSZheng BMosmann TRKobie JJDeLouise LA (2014 Sep 21). Microbubble array diffusion assay for the detection of cell secreted factors. Lab on a chip. Michaud HASenGupta Dde Mulder MDeeks SGMartin JNKobie JJSacha JBNixon DF (2014 Aug 15). Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells. Journal of immunology (Baltimore, Md. : 1950). Kobie JJTreanor JJRitchlin CT (2014). Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody. Immunological investigations. Jaworski JPKobie JBrower ZMalherbe DCLanducci GSutton WFGuo BReed JSLeon EJEngelmann FZheng BLegasse APark BDickerson MLewis ADColgin LMAxthelm MMessaoudi ISacha JBBurton DRForthal DNHessell AJHaigwood NL (2013 Oct). Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques. Journal of virology. Jones MCKobie JJDelouise LA (2013 Jun). Characterization of cell seeding and specific capture of B cells in microbubble well arrays. Biomedical microdevices. Sullivan MABrooks LRWeidenborner PDomm WMattiacio JXu QTiberio MWentworth TKobie JBryk PZheng BMurphy MSanz IDewhurst S (2013 Mar 12). Anti-idiotypic monobodies derived from a fibronectin scaffold. Biochemistry. Alcéna DCKobie JJKaminski DARosenberg AFMattiacio JLBrewer MDewhurst SDykes CJin XKeefer MCSanz I (2013). 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles. PloS one. Sullivan MAWentworth TKobie JJSanz I (2012 Sep). Anti-idiotypic monobodies for immune response profiling. Methods (San Diego, Calif.). Kobie JJAlcena DCZheng BBryk PMattiacio JLBrewer MLabranche CYoung FMDewhurst SMontefiori DCRosenberg AFFeng CJin XKeefer MCSanz I (2012). 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. PloS one. Kobie JJZheng BBryk PBarnes MRitchlin CTTabechian DAAnandarajah APLooney RJThiele RGAnolik JHCoca AWei CRosenberg AFFeng CTreanor JJLee FESanz I (2011). Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor. Arthritis research & therapy. Qi YOperario DJOberholzer CMKobie JJLooney RJGeoras SNMosmann TR (2010 Dec). Human basophils express amphiregulin in response to T cell-derived IL-3. The Journal of allergy and clinical immunology. Halliley JLKyu SKobie JJWalsh EEFalsey ARRandall TDTreanor JFeng CSanz ILee FE (2010 Apr 30). Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization. Vaccine. Mosmann TRKobie JJLee FEQuataert SA (2009 Dec). T helper cytokine patterns: defined subsets, random expression, and external modulation. Immunologic research. Hilchey SPKobie JJCochran MRSecor-Socha SWang JCHyrien OBurack WRMosmann TRQuataert SABernstein SH (2009 Nov 15). Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. Journal of immunology (Baltimore, Md. : 1950). Wang JCKobie JJZhang LCochran MMosmann TRRitchlin CTQuataert SA (2009 Feb 28). An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform. Journal of immunological methods. Kyu SYKobie JYang HZand MSTopham DJQuataert SASanz ILee FE (2009 Jan 1). Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells. Journal of immunological methods. Rebhahn JABishop CDivekar AAJiminez-Garcia KKobie JJLee FEMaupin GMSnyder-Cappione JEZaiss DMMosmann TR (2008 Oct). Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion. Computer methods and programs in biomedicine. Hamalainen-Laanaya HKKobie JJChang CZeng WP (2007 Nov 15). Temporal and spatial changes of histone 3 K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation. Journal of immunology (Baltimore, Md. : 1950). Zaiss DMYang LShah PRKobie JJUrban JFMosmann TR (2006 Dec 15). Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Science (New York, N.Y.). Kobie JJShah PRYang LRebhahn JAFowell DJMosmann TR (2006 Nov 15). T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. Journal of immunology (Baltimore, Md. : 1950). Hahn TAlvarez IKobie JJRamanathapuram LDial SFulton ABesselsen DWalker EAkporiaye ET (2006 May 1). Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. International journal of cancer. Yang LKobie JJMosmann TR (2005 Nov 15). CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells. Journal of immunology (Baltimore, Md. : 1950). Ramanathapuram LVKobie JJBearss DPayne CMTrevor KTAkporiaye ET (2004 Jul). alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells. Cancer immunology, immunotherapy : CII. Kobie JJWu RSKurt RALou SAdelman MKWhitesell LJRamanathapuram LVArteaga CLAkporiaye ET (2003 Apr 15). Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer research. Kobie JJAkporiaye ET (2003 Jan 01). Immunosuppressive Role of Transforming Growth Factor –Beta in Breast Cancer Clinical and Applied Immunology Reviews. Wu RSKobie JJBesselsen DGFong TCMack VDMcEarchern JAAkporiaye ET (2001 Jul). Comparative analysis of IFN-gamma B7.1 and antisense TGF-beta gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma. Cancer immunology, immunotherapy : CII. McEarchern JAKobie JJMack VWu RSMeade-Tollin LArteaga CLDumont NBesselsen DSeftor EHendrix MJKatsanis EAkporiaye ET (2001 Jan 1). Invasion and metastasis of a mammary tumor involves TGF-beta signaling. International journal of cancer. Kobie JJPeto JPrentice M (1994 Jan 01). Toughness response of electrodes within arc furnace cycling Materials Evaluation.