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Kuo Lab

Welcome to the Kuo Lab

Our multidisciplinary research team of engineers, biologists, orthopaedic surgeons, and sports medicine doctors are working together to pursue the following major thematic research areas in the Kuo Lab:

  • Tissue engineering with stem cells
  • Mechanobiology of tissue formation
  • Etiology of birth defects
  • Scarless wound healing

with significant focus on musculoskeletal tissue systems. The research objective is to inform tissue engineering and regenerative medicine strategies by recapitulating key aspects of embryonic tissue development and scarless healing. Our unique approach combines engineering techniques with classical embryo models to characterize the structure-property relationships of embryonic tissues as design parameters for engineering 3-dimensional (3D) polymeric scaffolds and bioreactor (mechanical loading) culture systems. We hypothesize 3D culture systems that present key embryonic tissue cues will instruct stem cells to regenerate new tissues, such as tendon and ligament, as replacement body parts. With this approach we are also developing unique benchtop tissue analogs, as complements to animal models, to study the mechanobiology of tissue formation and healing, with the goal of identifying novel targets for the development of new therapeutics.

Catherine K. Kuo, Ph.D.

Catherine K. Kuo, Ph.D.

Principal Investigator

Projects

  • Tendon tissue engineering
  • Stem cell potential for tenogenesis
  • Mechanobiology of embryonic tendon development
  • Animal and engineered tissue models of musculoskeletal birth defects
  • Embryonic scarless wound healing
  • Scaffolds and bioreactors to mechanoregulate stem cell differentiation
View All Projects

Publications

View All Publications

Upcoming Events

  • Thursday, October 25, 2018
    Catherine K. Kuo will deliver Keynote Lecture at the DKOU 2018 in Berlin, Germany
    Professor Kuo will deliver a Keynote Lecture entitled “Tendon Regeneration Strategies Inspired by the Embryonic Microenvironment” at the DKOU 2018 German Congress of Orthopaedics and Traumatology in Berlin, Germany, on October 25, 2018. More information can be found here: https://dkou.org/en/keynotes/#tab-id-2
  • Thursday, November 15, 2018
    Catherine K. Kuo will give invited talk at ORS Tendon Conference
    Professor Kuo will give an invited talk on “Embryonically Inspired Tendon Regeneration Approaches” at the ORS Tendon Section 2018 Conference held in Portland, OR, from November 15-17, 2018. More information can be seen here: https://www.ors.org/tendon-2018-conference/

Contact Us

  Kuo Lab
215 Robert B. Goergen Hall
Rochester, NY 14620