Welcome to the Kuo Lab
Our multidisciplinary research team of engineers, biologists, orthopaedic surgeons, and sports medicine doctors are working together to pursue the following major thematic research areas in the Kuo Lab:
- Tissue engineering with stem cells
- Mechanobiology of tissue formation
- Etiology of birth defects
- Scarless wound healing
with significant focus on musculoskeletal tissue systems. The research objective is to inform tissue engineering and regenerative medicine strategies by recapitulating key aspects of embryonic tissue development and scarless healing. Our unique approach combines engineering techniques with classical embryo models to characterize the structure-property relationships of embryonic tissues as design parameters for engineering 3-dimensional (3D) polymeric scaffolds and bioreactor (mechanical loading) culture systems. We hypothesize 3D culture systems that present key embryonic tissue cues will instruct stem cells to regenerate new tissues, such as tendon and ligament, as replacement body parts. With this approach we are also developing unique benchtop tissue analogs, as complements to animal models, to study the mechanobiology of tissue formation and healing, with the goal of identifying novel targets for the development of new therapeutics.