Skip to main content

Coronavirus (COVID-19): Visitor Restrictions, Resources, and Updates

Explore URMC

  • Kuo Group Photo
  • Kuo Research Photo 0
  • Kuo Research Photo 5
  • Kuo Research Photo 1
  • Kuo Research Photo 4
  • Kuo Research Photo 3
  • Kuo Research Photo 6

Kuo Lab

Welcome to the Kuo Lab

Our multidisciplinary research team of engineers, biologists, orthopaedic surgeons, and sports medicine doctors are working together to pursue the following major thematic research areas in the Kuo Lab:

  • Tissue engineering with stem cells
  • Mechanical regulation of tissue formation
  • Etiology of birth defects
  • Scarless wound healing

with significant focus on musculoskeletal tissue systems. The research objective is to inform tissue engineering and regenerative medicine strategies by recapitulating key aspects of embryonic tissue development and scarless healing. Our unique approach combines engineering techniques with classical embryo models to characterize the structure-property relationships of embryonic tissues as design parameters for engineering 3-dimensional (3D) polymeric scaffolds and bioreactor (mechanical loading) culture systems. We hypothesize 3D culture systems that present key embryonic tissue cues will instruct stem cells to regenerate new tissues, such as tendon and ligament, as replacement body parts. With this approach we are also developing unique benchtop tissue analogs, as complements to animal models, to study the mechanobiology of tissue formation and healing, with the goal of identifying novel targets for the development of new therapeutics.

Catherine K. Kuo, Ph.D.

Catherine K. Kuo, Ph.D.
Principal Investigator


  • Tendon tissue engineering
  • Stem cell potential for tenogenesis
  • Mechanical regulation and mechanobiology of embryonic tendon development
  • Animal and engineered tissue models of musculoskeletal birth defects
  • Embryonic scarless wound healing
  • Scaffolds and bioreactors to mechanically and chemically regulate stem cell differentiation
View All Projects


View All Publications

Contact Us

  Kuo Lab
215 Robert B. Goergen Hall
Rochester, NY 14620