Congratulations to Sabrina Xuan Pan On Her Presentation at the BMES 2017 Annual Conference
Thursday, October 12, 2017
Congratulations to Sabrina Xuan Pan for delivering an excellent podium presentation at the BMES 2017 Annual Conference in Phoenix AZ! Her talk was titled "Lysyl Oxidase Expression Patterns of Developing Embryonic Tendon", and was co-authored by Jiewen (Megerize) Li and Catherine K. Kuo.
Professor Kuo Receives NIH Funding
Thursday, October 12, 2017
Professor Catherine K. Kuo has received an NIH R01 grant for the project titled, "Tendon Tissue Engineering Informed by Lysyl Oxidase Regulation of Embryonic Tendon Mechanical Properties.” This project includes fellow BME faculty members Hani Awad, Edward Brown, and Mark Buckley as collaborators. This research will investigate the role of lysyl oxidase (LOX) in regulating tendon mechanical property development. The goal is to develop novel LOX-based strategies with stem cells to promote healing of injured tendons, which are unable to heal naturally.
Abstract: Musculoskeletal injuries are a leading cause of disability and medical costs in the United States. Approximately half of these injuries involve tendons and ligaments. The lifelong dysfunction, pain, and increased risk of re- injury due to poor healing have motivated our long-term goal to regenerate new tendon from stem cells to restore function and quality of life. Typical stem cell-based approaches aim to promote quantity of extracellular matrix (ECM) content, with the assumption that ECM quantity correlates with mechanical properties. However, these approaches have yet to achieve functional tendons. This has led us to ask how tendon develops naturally in the embryo to inform a mesenchymal stem cell (MSC)-based tendon regeneration approach. Our studies in the chick embryo recently showed that lysyl oxidase (LOX)-mediated crosslinking correlates strongly with mechanical properties during tendon development, and that inhibition of LOX activity reduces crosslinking and elastic modulus despite continued increases in matrix content. Furthermore, LOX activity appears to be regulated by embryonic kicking (mechanical loading). Based on these exciting data, we hypothesize LOX is a critical regulator of developing tendon mechanical properties, and that developmentally informed manipulation of LOX activity can promote functional tendon regeneration with MSC. The hypothesis will be tested with the following three specific aims: 1) determine LOX expression patterns and role in embryonic tendon mechanical property development; 2) elucidate how mechanical loading regulates LOX during embryonic tendon development; 3) develop approaches to enhance engineered MSC-construct mechanical properties via LOX-mediated crosslinking. The proposed work is innovative because our approach focuses on restoring ECM quality, rather than quantity, of the regenerating tendon matrix, and aims to inform this approach with embryonic development. Our novel strategy combines the chick embryo model with tissue engineering and bioreactor loading systems to investigate LOX and mechanical loading interactions in functional tendon development. Our long-term goal is to design developmentally inspired LOX-targeted therapies utilizing MSC to improve tendon mechanical properties.
Welcome new postdoctoral fellow Rafael Madero!
Sunday, October 1, 2017
Professor Kuo invited to deliver a Keynote at the Vail Scientific Summit on Regenerative & Translational Medicine
Friday, August 25, 2017
Professor Kuo delivered a Keynote talk on laboratory’s strategies to regenerate tendon at the 2017 Vail Scientific Summit on Regenerative & Translational Medicine in Colorado.
Congratulations to Xuan (Sabrina) Pan for being a Randy Rosier Talk Finalist at the URMC CMSR Symposium!
Friday, July 28, 2017
Sabrina was selected as a finalist for the Randy Rosier Talk Competition for trainees at the URMC Center for Musculoskeletal Research Annual Symposium. Congratulations to Sabrina for being one of the most junior trainees to be a finalist!
Congratulations to Xuan (Sabrina) Pan for being selected as an ORS Poster Award Finalist!
Friday, July 28, 2017
Congratulations to Sabrina for being selected as a Poster Award Finalist at the 1st Orthopaedic Research Society (ORS) Northeast Regional Symposium. Finalists were selected from the top scoring peer-reviewed abstracts. Great job, Sabrina!!
Professor Kuo organizes 1st Orthopaedic Research Society (ORS) Northeast Regional Symposium
Wednesday, July 26, 2017
As the ORS Ambassador for the Northeast, Professor Kuo organized the first ORS Northeast Regional Symposium, held at the University of Rochester in Rochester, NY. Plenary speakers included Professor Farshid Guilak (ORS past president), Dr. Fei Wang (NIH program director), and Dr. Michele Grimm (NSF program director). Nearly 200 attendees from 24 institutions across the U.S. and Canada attended and presented their research. The 2-day symposium was generously supported by the URMC Department of Orthopaedics, UR Department of Biomedical Engineering, and the ORS.
Professor Kuo scores in top 2 percentile with NIH R01 application
Friday, June 9, 2017
Professor Catherine K. Kuo recently received a 2 percentile rank for her NIH R01 application: “Tendon Tissue Engineering Informed by Lysyl Oxidase Regulation of Embryonic Tendon Mechanical Properties”. The goals of the grant are to characterize lysyl oxidase as a critical regulator of developing embryonic tendon mechanical properties, and to develop approaches to manipulate lysyl oxidase activity to promote functional tendon regeneration with stem cells.
Phong Nguyen passes First-Year PhD Exam
Monday, June 5, 2017
Congratulations to Phong Nguyen for successfully passing his First-Year PhD Exam!
Congratulations to new University of Rochester BME Graduates Samantha McGoldrick, Breanna O’Reilly, and Matthew Stein!
Sunday, May 21, 2017
Samantha, Breanna, and Matthew are officially UR BME graduates! In Fall 2017, Samantha will be a PhD candidate at the University of Michigan, and Breanna will be a PhD candidate at Boston University. Soon after graduating, Matthew accepted a position in the Kuo Lab. Congratulations to the three of you!
Professor Kuo invited to deliver seminar at Johns Hopkins University
Sunday, April 23, 2017
Professor Kuo was invited to speak about her research to the Department of Cell Biology at Johns Hopkins University School of Medicine.
Professor Kuo invited as William F. Neuman Visiting Scientist Speaker
Sunday, March 5, 2017
Professor Kuo delivered a seminar about her research as a William F. Neuman Visiting Scientist Speaker in the Center for Musculoskeletal Research Seminar Series at the University of Rochester.
Professors Kuo and Tuan co-chaired the 2017 Fusion Conference on Musculoskeletal Development and Regeneration in Cancun, Mexico
Monday, February 27, 2017
Professors Catherine K. Kuo and Rocky S. Tuan co-chaired the 2nd Fusion Conference on “Musculoskeletal Development and Regeneration” in Cancun, Mexico, February 24 – 27, 2017. This exciting conference is a premier scientific forum for the scientific investigation of the musculoskeletal system, including cartilage, bone, tendon, ligament, and muscle. Junior and senior investigators alike presented cutting edge research and had ample networking opportunities.