URMC / Labs / Maggirwar Lab / Publications Publications De Jesús Andino FJones LMaggirwar SBRobert J (2016). Frog Virus 3 dissemination in the brain of tadpoles, but not in adult Xenopus, involves blood brain barrier dysfunction. Scientific reports. Jones LDJackson JWMaggirwar SB (2016). Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction. PloS one. Singh VBSingh MVGorantla SPoluektova LYMaggirwar SB (2016). Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice. Scientific reports. Jackson JWSingh MVSingh VBJones LDDavidson GATure SMorrell CNSchifitto GMaggirwar SB (2016). Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis. PloS one. Piepenbrink MSSamuel MZheng BCarter BFucile CBunce CKiebala MKhan AAThakar JMaggirwar SBMorse DRosenberg AFHaughey NJValenti WKeefer MCKobie JJ (2016). Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PloS one. Singh VBWooten AKJackson JWMaggirwar SBKiebala M (2015 Apr). Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation. Journal of neurovirology. Kiebala MSkalska JCasulo CBrookes PSPeterson DRHilchey SPDai YGrant SMaggirwar SBBernstein SH (2015 Feb). Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach. Experimental hematology. Lannan KLSahler JKim NSpinelli SLMaggirwar SBGarraud OCognasse FBlumberg NPhipps RP (2015). Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles. Frontiers in immunology. Kiebala MSingh MVPiepenbrink MSQiu XKobie JJMaggirwar SB (2015). Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. PloS one. Singh MVDavidson DCJackson JWSingh VBSilva JRamirez SHMaggirwar SB (2014 May 15). Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. Journal of immunology (Baltimore, Md. : 1950). Ma QGelbard HAMaggirwar SBDewhurst SGendelman HEPeterson DRDiFrancesco RHochreiter JSMorse GDSchifitto G (2013 Jun). Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients. Journal of neurovirology. McMillan DHWoeller CFThatcher THSpinelli SLMaggirwar SBSime PJPhipps RP (2013 Jun 1). Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts. American journal of physiology. Lung cellular and molecular physiology. Davidson DCSchifitto GMaggirwar SB (2013). Valproic acid inhibits the release of soluble CD40L induced by non-nucleoside reverse transcriptase inhibitors in human immunodeficiency virus infected individuals. PloS one. Davidson DCJackson JWMaggirwar SB (2013). Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation? Journal of neuroinflammation. Singh MVDavidson DCKiebala MMaggirwar SB (2012 May). Detection of circulating platelet-monocyte complexes in persons infected with human immunodeficiency virus type-1. Journal of virological methods. Davidson DCHirschman MPSun ASingh MVKasischke KMaggirwar SB (2012). Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. PloS one. Morrell CNMaggirwar SB (2011 Sep). Recently recognized platelet agonists. Current opinion in hematology. McMillan DHBaglole CJThatcher THMaggirwar SSime PJPhipps RP (2011 Jul). Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation. The American journal of pathology. Davidson DCHirschman MPSpinelli SLMorrell CNSchifitto GPhipps RPMaggirwar SB (2011 Jan 1). Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals. Journal of immunology (Baltimore, Md. : 1950). Kulkarni AAThatcher THOlsen KCMaggirwar SBPhipps RPSime PJ (2011). PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PloS one. Kiebala MMaggirwar SB (2011). Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PloS one. Cao SWu CYang YSniderhan LFMaggirwar SBDewhurst SLu Y (2011). Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS. Journal of neuroinflammation. Xu XSteere RRFedorchuk CAPang JLee JYLim JHXu HPan ZKMaggirwar SBLi JD (2011). Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation. PloS one. Polesskaya OCunningham LLFrancis SPLuebke AEZhu XCollins DVasilyeva ONSahler JDesmet EAGelbard HAMaggirwar SBWalton JPFrisina RDDewhurst S (2010 Dec 1). Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing research. Perry SWBarbieri JTong NPolesskaya OPudasaini SStout ALu RKiebala MMaggirwar SBGelbard HA (2010 Oct 20). Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. The Journal of neuroscience : the official journal of the Society for Neuroscience. Gelbard HADewhurst SMaggirwar SBKiebala MPolesskaya OGendelman HE (2010 Oct). Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. Ramirez SHFan SDykstra HReichenbach NDel Valle LPotula RPhipps RPMaggirwar SBPersidsky Y (2010 Jul 14). Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. Desmet EAHollenbaugh JASime PJWright TWTopham DJSant AJTakimoto TDewhurst SMaggirwar SB (2010 May 10). Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. Spinelli SLCasey AEPollock SJGertz JMMcMillan DHNarasipura SDMody NAKing MRMaggirwar SBFrancis CWTaubman MBBlumberg NPhipps RP (2010 Mar). Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arteriosclerosis, thrombosis, and vascular biology. Eggert DDash PKGorantla SDou HSchifitto GMaggirwar SBDewhurst SPoluektova LGelbard HAGendelman HE (2010 Jan 15). Neuroprotective activities of CEP-1347 in models of neuroAIDS. Journal of immunology (Baltimore, Md. : 1950). Spinelli SLMaggirwar SBBlumberg NPhipps RP (2010). Nuclear emancipation: a platelet tour de force. Science signaling. Kiebala MPolesskaya OYao ZPerry SWMaggirwar SB (2010). Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production. PloS one. Sniderhan LFGarcia-Bates TMBurgart MBernstein SHPhipps RPMaggirwar SB (2009 Nov). Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma. Experimental hematology. Garcia-Bates TMPeslak SABaglole CJMaggirwar SBBernstein SHPhipps RP (2009 Jul). Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival. Cancer immunology, immunotherapy : CII. Schifitto GZhong JGill DPeterson DRGaugh MDZhu TTivarus MCruttenden KMaggirwar SBGendelman HEDewhurst SGelbard HA (2009 Apr). Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment. Journal of neurovirology. Skalska JBrookes PSNadtochiy SMHilchey SPJordan CTGuzman MLMaggirwar SBBriehl MMBernstein SH (2009). Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide. PloS one. Baglole CJMaggirwar SBGasiewicz TAThatcher THPhipps RPSime PJ (2008 Oct 24). The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. The Journal of biological chemistry. Sniderhan LFStout ALu YChao MVMaggirwar SB (2008 Jul). Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling. Molecular and cellular neurosciences. Yang SRValvo SYao HKode ARajendrasozhan SEdirisinghe ICaito SAdenuga DHenry RFromm GMaggirwar SLi JDBulger MRahman I (2008 Jun). IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. American journal of respiratory cell and molecular biology. Norman JPPerry SWReynolds HMKiebala MDe Mesy Bentley KLTrejo MVolsky DJMaggirwar SBDewhurst SMasliah EGelbard HA (2008). HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PloS one. Chugh PBradel-Tretheway BMonteiro-Filho CMPlanelles VMaggirwar SBDewhurst SKim B (2008). Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology. Pingle SCJajoo SMukherjea DSniderhan LFJhaveri KAMarcuzzi ARybak LPMaggirwar SBRamkumar V (2007 Oct). Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase. Molecular pharmacology. Wang JGigliotti FBhagwat SPMaggirwar SBWright TW (2007 Jun). Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism. American journal of physiology. Lung cellular and molecular physiology. Goyos AGuselnikov SChida ASSniderhan LFMaggirwar SBNedelkovska HRobert J (2007 Jun). Involvement of nonclassical MHC class Ib molecules in heat shock protein-mediated anti-tumor responses. European journal of immunology. Sui ZSniderhan LFSchifitto GPhipps RPGelbard HADewhurst SMaggirwar SB (2007 Mar 1). Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. Journal of immunology (Baltimore, Md. : 1950). Dewhurst SMaggirwar SBSchifitto GGendelman HEGelbard HA (2007 Mar). Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. Thatcher THMaggirwar SBBaglole CJLakatos HFGasiewicz TAPhipps RPSime PJ (2007 Mar). Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. The American journal of pathology. Chugh PFan SPlanelles VMaggirwar SBDewhurst SKim B (2007 Feb 9). Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. Journal of molecular biology. Cheng TPetraglia ALLi ZThiyagarajan MZhong ZWu ZLiu DMaggirwar SBDeane RFernández JALaRue BGriffin JHChopp MZlokovic BV (2006 Nov). Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature medicine. Ray DMMorse KMHilchey SPGarcia TMFelgar REMaggirwar SBPhipps RPBernstein SH (2006 Sep). The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway. Experimental hematology.