URMC / Labs / Maggirwar Lab / Publications Publications Piekna-Przybylska DMaggirwar SB CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres.; Cell cycle (Georgetown, Tex.). 2018 Sep 09. Falsetta MLFoster DCWoeller CFPollock SJBonham ADPiekna-Przybylska DMaggirwar SBHaidaris CGPhipps RP Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia.; Journal of lower genital tract disease; Vol 22(1). 2018 Jan. Singh VBSingh MVPiekna-Przybylska DGorantla SPoluektova LYMaggirwar SB Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection.; Scientific reports; Vol 7(1). 2017 Aug 29. Connor RJones LDQiu XThakar JMaggirwar SB Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.; Journal of leukocyte biology. 2017 Jun 29. Piekna-Przybylska DSharma GMaggirwar SBBambara RA Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.; Cell cycle (Georgetown, Tex.). 2017 Apr 07. Singh MVWeber EASingh VBStirpe NEMaggirwar SB Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?; Journal of neurovirology. 2017 Jan 23. De Jesús Andino FJones LMaggirwar SBRobert J Frog Virus 3 dissemination in the brain of tadpoles, but not in adult Xenopus, involves blood brain barrier dysfunction.; Scientific reports; Vol 6. 2016. Jones LDJackson JWMaggirwar SB Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction.; PloS one; Vol 11(3). 2016. Singh VBSingh MVGorantla SPoluektova LYMaggirwar SB Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice.; Scientific reports; Vol 6. 2016. Jackson JWSingh MVSingh VBJones LDDavidson GATure SMorrell CNSchifitto GMaggirwar SB Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.; PloS one; Vol 11(6). 2016. Piepenbrink MSSamuel MZheng BCarter BFucile CBunce CKiebala MKhan AAThakar JMaggirwar SBMorse DRosenberg AFHaughey NJValenti WKeefer MCKobie JJ Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.; PloS one; Vol 11(7). 2016. Singh VBWooten AKJackson JWMaggirwar SBKiebala M Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation.; Journal of neurovirology; Vol 21(2). 2015 Apr. Kiebala MSkalska JCasulo CBrookes PSPeterson DRHilchey SPDai YGrant SMaggirwar SBBernstein SH Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach.; Experimental hematology; Vol 43(2). 2015 Feb. Lannan KLSahler JKim NSpinelli SLMaggirwar SBGarraud OCognasse FBlumberg NPhipps RP Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles.; Frontiers in immunology; Vol 6. 2015. Kiebala MSingh MVPiepenbrink MSQiu XKobie JJMaggirwar SB Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse.; PloS one; Vol 10(6). 2015. Singh MVDavidson DCJackson JWSingh VBSilva JRamirez SHMaggirwar SB Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation.; Journal of immunology (Baltimore, Md. : 1950); Vol 192(10). 2014 May 15. Ma QGelbard HAMaggirwar SBDewhurst SGendelman HEPeterson DRDiFrancesco RHochreiter JSMorse GDSchifitto G Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.; Journal of neurovirology; Vol 19(3). 2013 Jun. McMillan DHWoeller CFThatcher THSpinelli SLMaggirwar SBSime PJPhipps RP Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts.; American journal of physiology. Lung cellular and molecular physiology; Vol 304(11). 2013 Jun 1. Davidson DCSchifitto GMaggirwar SB Valproic acid inhibits the release of soluble CD40L induced by non-nucleoside reverse transcriptase inhibitors in human immunodeficiency virus infected individuals.; PloS one; Vol 8(3). 2013. Davidson DCJackson JWMaggirwar SB Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?; Journal of neuroinflammation; Vol 10. 2013. Singh MVDavidson DCKiebala MMaggirwar SB Detection of circulating platelet-monocyte complexes in persons infected with human immunodeficiency virus type-1.; Journal of virological methods; Vol 181(2). 2012 May. Davidson DCHirschman MPSun ASingh MVKasischke KMaggirwar SB Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders.; PloS one; Vol 7(12). 2012. Morrell CNMaggirwar SB Recently recognized platelet agonists.; Current opinion in hematology; Vol 18(5). 2011 Sep. McMillan DHBaglole CJThatcher THMaggirwar SSime PJPhipps RP Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation.; The American journal of pathology; Vol 179(1). 2011 Jul. Kulkarni AAThatcher THOlsen KCMaggirwar SBPhipps RPSime PJ PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.; PloS one; Vol 6(1). 2011 Jan 06. Davidson DCHirschman MPSpinelli SLMorrell CNSchifitto GPhipps RPMaggirwar SB Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.; Journal of immunology (Baltimore, Md. : 1950); Vol 186(1). 2011 Jan 1. Kiebala MMaggirwar SB Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells.; PloS one; Vol 6(4). 2011. Cao SWu CYang YSniderhan LFMaggirwar SBDewhurst SLu Y Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS.; Journal of neuroinflammation; Vol 8. 2011. Xu XSteere RRFedorchuk CAPang JLee JYLim JHXu HPan ZKMaggirwar SBLi JD Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.; PloS one; Vol 6(11). 2011. Polesskaya OCunningham LLFrancis SPLuebke AEZhu XCollins DVasilyeva ONSahler JDesmet EAGelbard HAMaggirwar SBWalton JPFrisina RDDewhurst S Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.; Hearing research; Vol 270(1-2). 2010 Dec 1. Perry SWBarbieri JTong NPolesskaya OPudasaini SStout ALu RKiebala MMaggirwar SBGelbard HA Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 30(42). 2010 Oct 20. Gelbard HADewhurst SMaggirwar SBKiebala MPolesskaya OGendelman HE Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.; Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics; Vol 7(4). 2010 Oct. Ramirez SHFan SDykstra HReichenbach NDel Valle LPotula RPhipps RPMaggirwar SBPersidsky Y Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 30(28). 2010 Jul 14. Desmet EAHollenbaugh JASime PJWright TWTopham DJSant AJTakimoto TDewhurst SMaggirwar SB Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.; Virology; Vol 400(2). 2010 May 10. Spinelli SLCasey AEPollock SJGertz JMMcMillan DHNarasipura SDMody NAKing MRMaggirwar SBFrancis CWTaubman MBBlumberg NPhipps RP Platelets and megakaryocytes contain functional nuclear factor-kappaB.; Arteriosclerosis, thrombosis, and vascular biology; Vol 30(3). 2010 Mar. Eggert DDash PKGorantla SDou HSchifitto GMaggirwar SBDewhurst SPoluektova LGelbard HAGendelman HE Neuroprotective activities of CEP-1347 in models of neuroAIDS.; Journal of immunology (Baltimore, Md. : 1950); Vol 184(2). 2010 Jan 15. Spinelli SLMaggirwar SBBlumberg NPhipps RP Nuclear emancipation: a platelet tour de force.; Science signaling; Vol 3(144). 2010. Kiebala MPolesskaya OYao ZPerry SWMaggirwar SB Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production.; PloS one; Vol 5(7). 2010. Sniderhan LFGarcia-Bates TMBurgart MBernstein SHPhipps RPMaggirwar SB Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma.; Experimental hematology; Vol 37(11). 2009 Nov. Garcia-Bates TMPeslak SABaglole CJMaggirwar SBBernstein SHPhipps RP Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival.; Cancer immunology, immunotherapy : CII; Vol 58(7). 2009 Jul. Schifitto GZhong JGill DPeterson DRGaugh MDZhu TTivarus MCruttenden KMaggirwar SBGendelman HEDewhurst SGelbard HA Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.; Journal of neurovirology; Vol 15(2). 2009 Apr. Skalska JBrookes PSNadtochiy SMHilchey SPJordan CTGuzman MLMaggirwar SBBriehl MMBernstein SH Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.; PloS one; Vol 4(12). 2009. Baglole CJMaggirwar SBGasiewicz TAThatcher THPhipps RPSime PJ The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.; The Journal of biological chemistry; Vol 283(43). 2008 Oct 24. Sniderhan LFStout ALu YChao MVMaggirwar SB Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling.; Molecular and cellular neurosciences; Vol 38(3). 2008 Jul. Yang SRValvo SYao HKode ARajendrasozhan SEdirisinghe ICaito SAdenuga DHenry RFromm GMaggirwar SLi JDBulger MRahman I IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung.; American journal of respiratory cell and molecular biology; Vol 38(6). 2008 Jun. Norman JPPerry SWReynolds HMKiebala MDe Mesy Bentley KLTrejo MVolsky DJMaggirwar SBDewhurst SMasliah EGelbard HA HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.; PloS one; Vol 3(11). 2008. Chugh PBradel-Tretheway BMonteiro-Filho CMPlanelles VMaggirwar SBDewhurst SKim B Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.; Retrovirology; Vol 5. 2008. Pingle SCJajoo SMukherjea DSniderhan LFJhaveri KAMarcuzzi ARybak LPMaggirwar SBRamkumar V Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase.; Molecular pharmacology; Vol 72(4). 2007 Oct. Wang JGigliotti FBhagwat SPMaggirwar SBWright TW Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism.; American journal of physiology. Lung cellular and molecular physiology; Vol 292(6). 2007 Jun. Goyos AGuselnikov SChida ASSniderhan LFMaggirwar SBNedelkovska HRobert J Involvement of nonclassical MHC class Ib molecules in heat shock protein-mediated anti-tumor responses.; European journal of immunology; Vol 37(6). 2007 Jun.