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hBVR's Roles in the Cell Cycle

Cell growth signaling pathways

Cell growth signaling pathways, gene expression and activities
regulated by hBVR are indicated by check marks.

Cell cycle studies so far have shown that in the presence of IFN-γ, there is an increase in the number of cells in S-phase in GFP-BVR transfected HEK293 cells compared to control GFP cells, or to untreated cells. Our previous studies have shown that over-expression of hBVR led to cell cycle arrest in the G1/G0 phase, with concomitant reduction of S-phase cells. Similar results were observed with MCF-7 cells. The role of hBVR in regulating the cell cycle remains of interest. Previously, it was also shown that by 24 h after transfection, hBVR up-regulated Cyclin E1, Cyclin A, CDK-2, etc. and down-regulated E2F-3, RAD50, GADD45 etc., as measured by RT-PCR.

Our current studies have shown that phospho-p38 MAPK levels were increased within 30 minutes of TNF-α treatment in HEK293 cells. When cells were transfected with hBVR, phosphorylation of p38 MAP kinase in response to TNF-α treatment was reduced. These on-going studies demonstrate that BVR might be playing a dual role in these cells by inducing its anti-proliferative and pro-survival effects via different signaling mechanisms or pathways.

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