Regulation of hBVR Expression
It is apparent that hBVR regulates the activity of multiple pathways in the cell. The protein itself is ubiquitously expressed, but does not appear to respond rapidly at the level of transcription to external stimuli. To date, we have observed that gene expression from the hBVR promoter is up-regulated by hypoxia, and down-regulated by TNF-α (acting through NF-κB). Neither response causes rapid changes the level of hBVR mRNA. It is therefore likely that hBVR expression must be mediated by either of two mechanisms – changes in the levels of microRNAs could control mRNA stability, as could binding of proteins to the mRNA. Protein binding might also modulate translation of the mRNA. Study of these mechanisms is just starting in the laboratory.
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