URMC / Labs / Maines Lab / Publications Recent Publications Miralem TLerner-Marmarosh NGibbs PEJenkins JLHeimiller CMaines MD (2016 May 10). Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Vukomanovic DRahman MNMaines MDOzolinš TRSzarek WAJia ZNakatsu K (2016 Mar). Cysteine-independent activation/inhibition of heme oxygenase-2. Medical gas research. Gibbs PEMiralem TLerner-Marmarosh NMaines MD (2016). Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice. Journal of diabetes research. Gibbs PEMiralem TMaines MD (2015). Biliverdin reductase: a target for cancer therapy? Frontiers in pharmacology. Gibbs PELerner-Marmarosh NPoulin AFarah EMaines MD (2014 Jun). Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Miralem TLerner-Marmarosh NGibbs PETudor CHagen FKMaines MD (2012 Jul 13). The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cδ activity: the peptides are inhibitors or substrate for the protein kinase C. The Journal of biological chemistry. Gibbs PEMiralem TLerner-Marmarosh NTudor CMaines MD (2012 Jan 6). Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS). The Journal of biological chemistry. Gibbs PETudor CMaines MD (2012). Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C. Frontiers in pharmacology. Kapitulnik JMaines MD (2012). The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity, and cytoprotection. Frontiers in pharmacology. Ding BGibbs PEBrookes PSMaines MD (2011 Jan). The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Maines MD (2010 Dec). Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings. Current drug targets. Gibbs PEMiralem TMaines MD (2010 Sep). Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Miralem TGibbs PERevert FSaus JMaines MD (2010 Apr 23). Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression. The Journal of biological chemistry. Kapitulnik JMaines MD (2009 Mar). Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin. Trends in pharmacological sciences. Tudor CLerner-Marmarosh NEngelborghs YGibbs PEMaines MD (2008 Aug 1). Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin. The Biochemical journal. Lerner-Marmarosh NMiralem TGibbs PEMaines MD (2008 May 13). Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proceedings of the National Academy of Sciences of the United States of America. Lerner-Marmarosh NMiralem TGibbs PEMaines MD (2007 Dec). Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Gibbs PEMaines MD (2007 Dec 1). Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase. International journal of cancer. Maines MD (2007 Dec). Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways. Antioxidants & redox signaling. Maines MDMiralem TLerner-Marmarosh NShen JGibbs PE (2007 Mar 16). Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. The Journal of biological chemistry. Ewing JFMaines MD (2006 Apr). Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response. Journal of neural transmission (Vienna, Austria : 1996). Calabrese VMaines MD (2006 Mar). Antiaging medicine: antioxidants and aging. Antioxidants & redox signaling. Calabrese VButterfield DAScapagnini GStella AMMaines MD (2006 Mar). Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity. Antioxidants & redox signaling. Maines MDGibbs PE (2005 Dec 9). 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events. Biochemical and biophysical research communications. Maines MD (2005 Dec). New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda, Md.). Maines MD (2005 Nov). The heme oxygenase system: update 2005. Antioxidants & redox signaling. Lerner-Marmarosh NShen JTorno MDKravets AHu ZMaines MD (2005 May 17). Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. Miralem THu ZTorno MDLelli KMMaines MD (2005 Apr 29). Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. The Journal of biological chemistry. Maines MD (2004 Oct). The heme oxygenase system: past, present, and future. Antioxidants & redox signaling. Kravets AHu ZMiralem TTorno MDMaines MD (2004 May 7). Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1. The Journal of biological chemistry. Mayer RDWang XMaines MD (2003 Jul). Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase. The Journal of pharmacology and experimental therapeutics. Wang XHauptmann NTaylor EForeman MKhawli LAMaines MD (2003 Feb 7). Neotrofin increases heme oxygenase-1 selectively in neurons. Brain research. Maines MD (2003 Jan). Bile pigments: newcomers to the cell signaling arena. Toxicological sciences : an official journal of the Society of Toxicology. Whitby FGPhillips JDHill CPMcCoubrey WMaines MD (2002 Jun 21). Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. Journal of molecular biology. Ahmad ZSalim MMaines MD (2002 Mar 15). Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress. The Journal of biological chemistry. Maines MD (2002). Heme oxygenase 1 transgenic mice as a model to study neuroprotection. Methods in enzymology. Maines MDPanahian N (2002 Jan 01). The heme oxygenase system and cellular defense mechanisms: Do HO-1 and HO-2 have different functions? Hypoxia from Genese to the Bedside Advances in Experimental Medicine and Biology (Roach, R.C., Wagner, P.G., Hackett, P.H. eds.) Kluwer Academic/Plenum Pub., New York. Huang TJMcCoubrey WKMaines MD (2001 Aug). Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs. Antioxidants & redox signaling. Maines MD (2001 May). Overview of heme degradation pathway. Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]. Salim MBrown-Kipphut BAMaines MD (2001 Apr 6). Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation. The Journal of biological chemistry. Maines MDEwing JFHuang TJPanahian N (2001 Mar). Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1. The Journal of pharmacology and experimental therapeutics. Panahian NMaines MD (2001 Jan). Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms? Journal of neurochemistry. Maines MDPanahian N (2001). The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Advances in experimental medicine and biology. Panahian NMaines MD (2000 Nov). Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion. Brain research. Brain research protocols. Chen KGunter KMaines MD (2000 Jul). Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. Journal of neurochemistry. Maines MD (2000 May). The heme oxygenase system and its functions in the brain. Cellular and molecular biology (Noisy-le-Grand, France). Chen KMaines MD (2000 May). Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cellular and molecular biology (Noisy-le-Grand, France). Liu NWang XMcCoubrey WKMaines MD (2000 Jan 4). Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression. Gene. Panahian NHuang TMaines MD (1999 Dec 11). Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia. Brain research. Maines MDRaju VSPanahian N (1999 Nov). Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury. The Journal of pharmacology and experimental therapeutics.