URMC / Labs / Maines Lab / Publications Recent Publications Miralem TLerner-Marmarosh NGibbs PEJenkins JLHeimiller CMaines MD Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 May 10. Vukomanovic DRahman MNMaines MDOzolinš TRSzarek WAJia ZNakatsu K Cysteine-independent activation/inhibition of heme oxygenase-2.; Medical gas research; Vol 6(1). 2016 Mar. Gibbs PEMiralem TLerner-Marmarosh NMaines MD Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice.; Journal of diabetes research; Vol 2016. 2016. Gibbs PEMiralem TMaines MD Biliverdin reductase: a target for cancer therapy?; Frontiers in pharmacology; Vol 6. 2015. Gibbs PELerner-Marmarosh NPoulin AFarah EMaines MD Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 28(6). 2014 Jun. Miralem TLerner-Marmarosh NGibbs PETudor CHagen FKMaines MD The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cδ activity: the peptides are inhibitors or substrate for the protein kinase C.; The Journal of biological chemistry; Vol 287(29). 2012 Jul 13. Gibbs PEMiralem TLerner-Marmarosh NTudor CMaines MD Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS).; The Journal of biological chemistry; Vol 287(2). 2012 Jan 6. Gibbs PETudor CMaines MD Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C.; Frontiers in pharmacology; Vol 3. 2012. Kapitulnik JMaines MD The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity, and cytoprotection.; Frontiers in pharmacology; Vol 3. 2012. Ding BGibbs PEBrookes PSMaines MD The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 25(1). 2011 Jan. Maines MD Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings.; Current drug targets; Vol 11(12). 2010 Dec. Gibbs PEMiralem TMaines MD Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 24(9). 2010 Sep. Miralem TGibbs PERevert FSaus JMaines MD Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression.; The Journal of biological chemistry; Vol 285(17). 2010 Apr 23. Kapitulnik JMaines MD Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.; Trends in pharmacological sciences; Vol 30(3). 2009 Mar. Tudor CLerner-Marmarosh NEngelborghs YGibbs PEMaines MD Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin.; The Biochemical journal; Vol 413(3). 2008 Aug 1. Lerner-Marmarosh NMiralem TGibbs PEMaines MD Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 105(19). 2008 May 13. Lerner-Marmarosh NMiralem TGibbs PEMaines MD Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 21(14). 2007 Dec. Gibbs PEMaines MD Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase.; International journal of cancer; Vol 121(11). 2007 Dec 1. Maines MD Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways.; Antioxidants & redox signaling; Vol 9(12). 2007 Dec. Maines MDMiralem TLerner-Marmarosh NShen JGibbs PE Human biliverdin reductase, a previously unknown activator of protein kinase C betaII.; The Journal of biological chemistry; Vol 282(11). 2007 Mar 16. Ewing JFMaines MD Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response.; Journal of neural transmission (Vienna, Austria : 1996); Vol 113(4). 2006 Apr. Calabrese VMaines MD Antiaging medicine: antioxidants and aging.; Antioxidants & redox signaling; Vol 8(3-4). 2006 Mar. Calabrese VButterfield DAScapagnini GStella AMMaines MD Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.; Antioxidants & redox signaling; Vol 8(3-4). 2006 Mar. Maines MDGibbs PE 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events.; Biochemical and biophysical research communications; Vol 338(1). 2005 Dec 9. Maines MD New insights into biliverdin reductase functions: linking heme metabolism to cell signaling.; Physiology (Bethesda, Md.); Vol 20. 2005 Dec. Maines MD The heme oxygenase system: update 2005.; Antioxidants & redox signaling; Vol 7(11-12). 2005 Nov. Lerner-Marmarosh NShen JTorno MDKravets AHu ZMaines MD Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(20). 2005 May 17. Miralem THu ZTorno MDLelli KMMaines MD Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.; The Journal of biological chemistry; Vol 280(17). 2005 Apr 29. Maines MD The heme oxygenase system: past, present, and future.; Antioxidants & redox signaling; Vol 6(5). 2004 Oct. Kravets AHu ZMiralem TTorno MDMaines MD Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1.; The Journal of biological chemistry; Vol 279(19). 2004 May 7. Mayer RDWang XMaines MD Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase.; The Journal of pharmacology and experimental therapeutics; Vol 306(1). 2003 Jul. Wang XHauptmann NTaylor EForeman MKhawli LAMaines MD Neotrofin increases heme oxygenase-1 selectively in neurons.; Brain research; Vol 962(1-2). 2003 Feb 7. Maines MD Bile pigments: newcomers to the cell signaling arena.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 71(1). 2003 Jan. Whitby FGPhillips JDHill CPMcCoubrey WMaines MD Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.; Journal of molecular biology; Vol 319(5). 2002 Jun 21. Ahmad ZSalim MMaines MD Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress.; The Journal of biological chemistry; Vol 277(11). 2002 Mar 15. Maines MD Heme oxygenase 1 transgenic mice as a model to study neuroprotection.; Methods in enzymology; Vol 353. 2002. Maines MDPanahian N The heme oxygenase system and cellular defense mechanisms: Do HO-1 and HO-2 have different functions? Hypoxia from Genese to the Bedside; Advances in Experimental Medicine and Biology (Roach, R.C., Wagner, P.G., Hackett, P.H. eds.) Kluwer Academic/Plenum Pub., New York; Vol 502(3), pp. 249-271. 2002 Jan 01. Huang TJMcCoubrey WKMaines MD Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs.; Antioxidants & redox signaling; Vol 3(4). 2001 Aug. Maines MD Overview of heme degradation pathway.; Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]; Vol Chapter 9. 2001 May. Salim MBrown-Kipphut BAMaines MD Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation.; The Journal of biological chemistry; Vol 276(14). 2001 Apr 6. Maines MDEwing JFHuang TJPanahian N Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1.; The Journal of pharmacology and experimental therapeutics; Vol 296(3). 2001 Mar. Panahian NMaines MD Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms?; Journal of neurochemistry; Vol 76(2). 2001 Jan. Maines MDPanahian N The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions?; Advances in experimental medicine and biology; Vol 502. 2001. Panahian NMaines MD Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion.; Brain research. Brain research protocols; Vol 6(1-2). 2000 Nov. Chen KGunter KMaines MD Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death.; Journal of neurochemistry; Vol 75(1). 2000 Jul. Maines MD The heme oxygenase system and its functions in the brain.; Cellular and molecular biology (Noisy-le-Grand, France); Vol 46(3). 2000 May. Chen KMaines MD Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38.; Cellular and molecular biology (Noisy-le-Grand, France); Vol 46(3). 2000 May. Liu NWang XMcCoubrey WKMaines MD Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression.; Gene; Vol 241(1). 2000 Jan 4. Panahian NHuang TMaines MD Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia.; Brain research; Vol 850(1-2). 1999 Dec 11. Maines MDRaju VSPanahian N Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury.; The Journal of pharmacology and experimental therapeutics; Vol 291(2). 1999 Nov.