Arenaviruses merit significant interest as clinically important human pathogens, including several causative agents of hemorrhagic fever disease. Using Lymphocytic Choriomeningitis Virus (LCMV), the prototype member in the family, Dr. Martinez-Sobrido have found that the viral nucleoprotein (NP) inhibits the IFN response in infected cells by interfering with the activation of the Interferon Regulatory Factor-3.
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Influenza viruses are globally important human pathogens that affect up to 500 million people annually. During the effective replication cycle of the virus in its hosts, Influenza non-structural protein 1 (NS1) has been demonstrated to perform several important functions.
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Originally discovered by the British virologist Alick Isaacks and the Swiss researcher Jean Lindenmann (Picture, above), at the National Institute for Medical Research in London, 1957, Interferon (IFN) plays an important key role in the host antiviral innate immune response.
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Another important aspect in Dr. Martinez-Sobrido research is the development of vaccines against viral infections. To that end, he is using attenuated forms of influenza virus that can be used as life attenuated vaccines for use in humans.
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