Welcome to the Mehta Lab
Our lab investigates potential novel therapeutic targets for ischemic brain injuries. We aim to better understand the etiologies and pathophysiology of stroke and cerebral small vessel disease. In particular, our current studies investigate structure of the cerebral vasculature and effects of ischemia on blood-brain barrier integrity and neuronal survival. Investigations in our lab are performed using the rat MCAo stroke model, in vitro tissue culture and postmortem human brains. Pharmacological inhibition and gene knockdown are used to explore cellular and molecular causes and potential treatments for post-ischemic brain damage.