URMC / Labs / Munger Lab / Publications Recent Publications Smith BSchafer XLAmbeskovic ASpencer CMLand HMunger J (2016 Oct 11). Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells. Cell reports. Nadtochiy SMSchafer XFu DNehrke KMunger JBrookes PS (2016 Aug 10). Acidic pH is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling. The Journal of biological chemistry. Xu SSchafer XMunger J (2016 May 1). Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection. Journal of virology. Hollenbaugh JAMontero CSchinazi RFMunger JKim B (2016 Apr). Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages. Virology. Goodwin CMXu SMunger J (2015 Dec). Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network. Trends in microbiology. Nadtochiy SMUrciuoli WZhang JSchafer XMunger JBrookes PS (2015 Nov). Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. Journal of molecular and cellular cardiology. Campbell ABushman JMunger JNoble MPröschel CMayer-Pröschel M (2015 Oct 15). Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia. Glia. Buescher JMAntoniewicz MRBoros LGBurgess SCBrunengraber HClish CBDeBerardinis RJFeron OFrezza CGhesquiere BGottlieb EHiller KJones RGKamphorst JJKibbey RGKimmelman ACLocasale JWLunt SYMaddocks ODMalloy CMetallo CMMeuillet EJMunger JNöh KRabinowitz JDRalser MSauer UStephanopoulos GSt-Pierre JTennant DAWittmann CVander Heiden MGVazquez AVousden KYoung JDZamboni NFendt SM (2015 Aug). A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current opinion in biotechnology. Xu SSpencer CMMunger J (2015 Jun). Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition. Journal of virology. DeVito SROrtiz-Riaño EMartínez-Sobrido LMunger J (2014 Dec 16). Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation. Proceedings of the National Academy of Sciences of the United States of America. Mathers CSchafer XMartínez-Sobrido LMunger J (2014 Dec). The human cytomegalovirus UL26 protein antagonizes NF-κB activation. Journal of virology. Proschel CStripay JLShih CHMunger JCNoble MD (2014 Apr). Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons. EMBO molecular medicine. Ortiz-Riaño ENgo NDevito SEggink DMunger JShaw MLde la Torre JCMartínez-Sobrido L (2014 Jan). Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor. Journal of virology. Mathers CSpencer CMMunger J (2014). Distinct domains within the human cytomegalovirus U(L)26 protein are important for wildtype viral replication and virion stability. PloS one. Pei SMinhajuddin MCallahan KPBalys MAshton JMNeering SJLagadinou EDCorbett CYe HLiesveld JLO'Dwyer KMLi ZShi LGreninger PSettleman JBenes CHagen FKMunger JCrooks PABecker MWJordan CT (2013 Nov 22). Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. The Journal of biological chemistry. Sasaki MKnobbe CBMunger JCLind EFBrenner DBrüstle AHarris ISHolmes RWakeham AHaight JYou-Ten ALi WYSchalm SSu SMVirtanen CReifenberger GOhashi PSBarber DLFigueroa MEMelnick AZúñiga-Pflücker JCMak TW (2012 Aug 30). IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. McArdle JMoorman NJMunger J (2012 Jan). HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication. PLoS pathogens. Wang RDillon CPShi LZMilasta SCarter RFinkelstein DMcCormick LLFitzgerald PChi HMunger JGreen DR (2011 Dec 23). The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. Hollenbaugh JAMunger JKim B (2011 Jul 5). Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC-MS/MS analysis. Virology. Spencer CMSchafer XLMoorman NJMunger J (2011 Jun). Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. Journal of virology. McArdle JSchafer XLMunger J (2011 Jan). Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny. Journal of virology. Munger JBennett BDParikh AFeng XJMcArdle JRabitz HAShenk TRabinowitz JD (2008 Oct). Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nature biotechnology. Munger JBajad SUColler HAShenk TRabinowitz JD (2006 Dec). Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS pathogens. Munger JYu DShenk T (2006 Apr). UL26-deficient human cytomegalovirus produces virions with hypophosphorylated pp28 tegument protein that is unstable within newly infected cells. Journal of virology. Benetti LMunger JRoizman B (2003 Jun). The herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BAD. Journal of virology. Munger JHagglund RRoizman B (2003 Jan 20). Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis. Virology. Munger JZhou GRoizman B (2003 Jan 01). Cell death on demand: Herpes simplex viruses and apoptosis In C. D. O?Connor (ed.), Microbial Subversion of Host Cells, Cambridge University Press, Cambridge. Hagglund RMunger JPoon APRoizman B (2002 Jan). U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner. Journal of virology. Munger JRoizman B (2001 Aug 28). The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins. Proceedings of the National Academy of Sciences of the United States of America. Munger JChee AVRoizman B (2001 Jun). The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage. Journal of virology. Galvan VBrandimarti RMunger JRoizman B (2000 Feb). Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells. Journal of virology.