Skip to main content
menu

  • Munger Research - Group Photo
  • Munger Research - Cells Photo
  • Munger Research - microscope photo

Munger Lab

Virus-Host Interactions that Determine Infectious Outcomes

Kegg Pathway

Representation of the cellular metabolome.
(Modified from the KEGG Pathway Database)
View image enlargement

A major focus of our laboratory is  human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns. HCMV infection also poses a serious health risk to immunosuppressed individuals, increasing morbidity in the elderly and in patients receiving immunosuppressive chemotherapy, including cancer patients, transplant recipients, and AIDS patients.

The majority of the projects in our lab study the interfaces between viruses and the host cell that determine the outcome of infection. Specifically, we focus on how viruses usurp cellular metabolic controls and subvert cellular anti-viral signaling to support productive infection. The goal of our laboratory is to increase our mechanistic understanding of these processes to identify novel avenues for therapeutic intervention that could prevent virally-associated pathogenesis.      

Joshua C. Munger, Ph.D.

Joshua C. Munger, Ph.D.
Principal Investigator

Publications

    1. Rasmussen AL
    2. Gronvall GK
    3. Lowen AC
    4. Goodrum F
    5. Alwine J
    6. Andersen KG
    7. Anthony SJ
    8. Baines J
    9. Banerjee A
    10. Broadbent AJ
    11. Brooke CB
    12. Campos SK
    13. Caposio P
    14. Casadevall A
    15. Chan GC
    16. Cliffe AR
    17. Collins-McMillen D
    18. Connell N
    19. Damania B
    20. Daugherty MD
    21. Debbink K
    22. Dermody TS
    23. DiMaio D
    24. Duprex WP
    25. Emerman M
    26. Galloway DA
    27. Garry RF
    28. Goldstein SA
    29. Greninger AL
    30. Hartman AL
    31. Hogue BG
    32. Horner SM
    33. Hotez PJ
    34. Jung JU
    35. Kamil JP
    36. Karst SM
    37. Laimins L
    38. Lakdawala SS
    39. Landais I
    40. Letko M
    41. Lindenbach B
    42. Liu S-L
    43. Luftig M
    44. McFadden G
    45. Mehle A
    46. Morrison J
    47. Moscona A
    48. Mühlberger E
    49. Munger J
    50. Münger K
    51. Murphy E
    52. Neufeldt CJ
    53. Nikolich JZ
    54. O'Connor CM
    55. Pekosz A
    56. Permar SR
    57. Pfeiffer JK
    58. Popescu SV
    59. Purdy JG
    60. Racaniello VR
    61. Rice CM
    62. Runstadler JA
    63. Sapp MJ
    64. Scott RS
    65. Smith GA
    66. Sorrell EM
    67. Speranza E
    68. Streblow D
    69. Tibbetts SA
    70. Toth Z
    71. Van Doorslaer K
    72. Weiss SR
    73. White EA
    74. White TM
    75. Wobus CE
    76. Worobey M
    77. Yamaoka S
    78. Yurochko A
    Virology-the path forward.; Journal of virology. 2024 Jan 03.
    1. Wu J
    2. Subbaiah KCV
    3. Hedaya O
    4. Chen S
    5. Munger J
    6. Tang WHW
    7. Yan C
    8. Yao P
    FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.; Cardiovascular research. 2023 Jul 31.
    1. Dunn DM
    2. Pack LJ
    3. Munger JC
    Raf1 promotes successful Human Cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infection.; bioRxiv : the preprint server for biology. 2023 Jul 26.
    1. Zhang K
    2. Eldin P
    3. Ciesla JH
    4. Briant L
    5. Lentini JM
    6. Ramos J
    7. Cobb J
    8. Munger J
    9. Fu D
    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease.; bioRxiv : the preprint server for biology. 2023 Jul 20.
    1. Asantewaa G
    2. Tuttle ET
    3. Ward NP
    4. Kang YP
    5. Kim Y
    6. Kavanagh ME
    7. Girnius N
    8. Chen Y
    9. Duncan R
    10. Rodriguez K
    11. Hecht F
    12. Zocchi M
    13. Smorodintsev-Schiller L
    14. Scales TQ
    15. Taylor K
    16. Alimohammadi F
    17. Sechrist ZR
    18. Agostini-Vulaj D
    19. Schafer XL
    20. Chang H
    21. Smith Z
    22. O'Connor TN
    23. Whelan S
    24. Selfors LM
    25. Crowdis J
    26. Gray GK
    27. Bronson RT
    28. Brenner D
    29. Rufini A
    30. Dirksen RT
    31. Hezel AF
    32. Huber AR
    33. Munger J
    34. Cravatt BF
    35. Vasiliou V
    36. Cole CL
    37. DeNicola GM
    38. Harris IS
    Glutathione supports lipid abundance in vivo.; bioRxiv : the preprint server for biology. 2023 Feb 11.
    1. Goodrum F
    2. Lowen A
    3. Lakdawala S
    4. Alwine J
    5. Casadevall A
    6. Imperiale M
    7. Atwood W
    8. Avgousti D
    9. Baines J
    10. Banfield B
    11. Banks L
    12. Bhaduri-McIntosh S
    13. Bhattacharya D
    14. Blanco-Melo D
    15. Bloom D
    16. Boon A
    17. Boulant S
    18. Brandt C
    19. Broadbent A
    20. Brooke C
    21. Cameron C
    22. Campos S
    23. Caposio P
    24. Chan G
    25. Cliffe A
    26. Coffin J
    27. Collins K
    28. Damania B
    29. Daugherty M
    30. Debbink K
    31. DeCaprio J
    32. Dermody T
    33. Dikeakos J
    34. DiMaio D
    35. Dinglasan R
    36. Duprex WP
    37. Dutch R
    38. Elde N
    39. Emerman M
    40. Enquist L
    41. Fane B
    42. Fernandez-Sesma A
    43. Flenniken M
    44. Frappier L
    45. Frieman M
    46. Frueh K
    47. Gack M
    48. Gaglia M
    49. Gallagher T
    50. Galloway D
    51. García-Sastre A
    52. Geballe A
    53. Glaunsinger B
    54. Goff S
    55. Greninger A
    56. Hancock M
    57. Harris E
    58. Heaton N
    59. Heise M
    60. Heldwein E
    61. Hogue B
    62. Horner S
    63. Hutchinson E
    64. Hyser J
    65. Jackson W
    66. Kalejta R
    67. Kamil J
    68. Karst S
    69. Kirchhoff F
    70. Knipe D
    71. Kowalik T
    72. Lagunoff M
    73. Laimins L
    74. Langlois R
    75. Lauring A
    76. Lee B
    77. Leib D
    78. Liu SL
    79. Longnecker R
    80. Lopez C
    81. Luftig M
    82. Lund J
    83. Manicassamy B
    84. McFadden G
    85. McIntosh M
    86. Mehle A
    87. Miller WA
    88. Mohr I
    89. Moody C
    90. Moorman N
    91. Moscona A
    92. Mounce B
    93. Munger J
    94. Münger K
    95. Murphy E
    96. Naghavi M
    97. Nelson J
    98. Neufeldt C
    99. Nikolich J
    100. O'Connor C
    101. Ono A
    102. Orenstein W
    103. Ornelles D
    104. Ou JH
    105. Parker J
    106. Parrish C
    107. Pekosz A
    108. Pellett P
    109. Pfeiffer J
    110. Plemper R
    111. Polyak S
    112. Purdy J
    113. Pyeon D
    114. Quinones-Mateu M
    115. Renne R
    116. Rice C
    117. Schoggins J
    118. Roller R
    119. Russell C
    120. Sandri-Goldin R
    121. Sapp M
    122. Schang L
    123. Schmid S
    124. Schultz-Cherry S
    125. Semler B
    126. Shenk T
    127. Silvestri G
    128. Simon V
    129. Smith G
    130. Smith J
    131. Spindler K
    132. Stanifer M
    133. Subbarao K
    134. Sundquist W
    135. Suthar M
    136. Sutton T
    137. Tai A
    138. Tarakanova V
    139. tenOever B
    140. Tibbetts S
    141. Tompkins S
    142. Toth Z
    143. van Doorslaer K
    144. Vignuzzi M
    145. Wallace N
    146. Walsh D
    147. Weekes M
    148. Weinberg J
    149. Weitzman M
    150. Weller S
    151. Whelan S
    152. White E
    153. Williams B
    154. Wobus C
    155. Wong S
    156. Yurochko A
    Virology under the Microscope-a Call for Rational Discourse.; mBio. 2023 Jan 26.

View All Publications

Contact Us

  Munger Lab
MC 3-7544
601 Elmwood Ave
Rochester, NY 14642

 (585) 273-4801

  (585) 271-2683