Mechanisms of Metabolic Reprogramming by Human Cytomegalovirus
A major focus of our laboratory is on human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns. HCMV infection also poses a serious health risk to immunosuppressed individuals, such as the elderly, and patients receiving immunosuppressive chemotherapy, including cancer patients, transplant recipients, and AIDS patients.
Utilizing LC-MS/MS metabolomic profiling, we have previously found that HCMV infection induces dramatic changes to the host-cell metabolic network including activation of numerous aspects of cellular carbon and nitrogen metabolism. Currently, our lab is focused on two key metabolic pathways that are necessary for high-titer replication, glycolysis and fatty acid biosynthesis. Our research focuses on both the mechanisms through which these pathways are activated during HCMV infection and also the means by which these metabolic pathways contribute to the production of viral progeny.
Reorganization of cellular secretory apparatus by HCMV infection.
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