CNS Neuroinflammation Research
There is increasing recognition that inflammatory processes underlie many acute and chronic diseases, including those of the central nervous system (CNS). In particular, the glial and vascular components of the brain play significant and unique roles in inflammatory processes, both as sources of inflammatory mediators and as targets for local innate and acquired immune responses. Moreover, there is increasing recognition of the importance for glia in all aspects of brain function, ranging from normal homeostasis to repair and repopulation following injury. Our laboratories utilize mouse models to focus on the role of neuroinflammation in neurodegeneration and CNS injury.
Current Research Projects
- Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis.Dev Neurobiol. 76, 533-50. (2016 May 01).
- Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling.J Neuroinflammation. 13, 30. (2016 Jan 01).
- Characterization of binge-dosed methamphetamine-induced neurotoxicity and neuroinflammation.Neurotoxicology. 50, 131-41. (2015 Sep 01).