Drs. Catherine Ovitt & Szilvia
Arany's article, Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in
vivo
journal Molecular Therapy, has been featured on NIDCR website. The results of the study suggest that
optimization of in vivo siRNA-mediated silencing for clinical application could be an effective means of
protecting salivary glands in the radiation treatment of head and neck cancer. They also pointed out that the
approach has significant advantages over alternative methods, as it is limited to the salivary glands, does not
involve viruses, and the block in PkcĪ“ protein expression is only temporary.