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Cell-Based Therapies for Salivary Gland Dysfunction

The salivary glands are composed of clustered secretory acinar cells, which drain into a ductal tree. Additional myoepithelial, neuronal, and endothelial cells provide structural framework. In collaboration with Dr. Danielle Benoit, Department of Biomedical Engineering, we are investigating the use of poly(ethylene glycol) (PEG) hydrogels as bioengineered scaffolds for salivary gland tissue engineering. Our investigations combine the use of genetic mouse models, and bioengineered hydrogels to discover conditions for cell viability and expansion for development of cell-based therapies.

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