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Paine Lab

Molecular Mechanisms of Inflammatory Bone Diseases

Psoriatic arthritis (PsA) is a prevalent musculoskeletal disorder which develops in up to 30% of patients with psoriasis and is associated with several co-morbidities that increase the risk of cardiovascular disease. Currently there is no diagnostic test for PsA and no identified biomarkers to predict the risk of developing arthritis once psoriasis is present. Defining such markers would be instrumental in earlier and more accurate diagnosis and treatment.


    1. Paine A
    2. Dorresteijn MJ
    3. Zilian E
    4. Maaike GE
    5. Blasczyk R
    6. Wagener F
    7. Pickkers P
    8. Immenschuh S
    Lipopolysaccharide-Dependent Down-Regulation of Heme Oxygenase-1 via a Bach1-Regulated Pathway in Human Mononuclear; Free Radic Biol Med; Vol S0891-5849(14), pp. 1080-6. 2014 Jan 01.
    1. Saragih H
    2. Zilian E
    3. Jaimes Y'
    4. Paine A
    5. Figueiredo C
    6. Eiz-Vesper B
    7. Blasczyk R
    8. Larmann J
    9. Theilmeier G
    10. Andrei-Selmer C
    11. Becker J
    12. Santoso S
    13. Immenschuh S
    PECAM-1 Regulates Endothelial Heme Oxygenase-1 Expression via a Redox-dependent Nrf2-Mediated; Thrombosis and Haemostasis; Vol 111(6). 2014 Jan 01.
    1. Jagodic M
    2. Stridh P
    3. Gad AK
    4. Paine A
    5. Udekwu KI
    6. Sjöholm LK
    7. Svensson M
    8. Pan-Hammarström Q
    Nurture your scientific curiosity early in your research; Nat Genet; Vol 45(2), pp. 116-8. 2013 Jan 01.

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 Paine Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642