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B-Lymphocytes, Antibody Production and Vaccines

lymphocytesThis project studies how small lipid mediators regulate the growth, activation and differentiation of normal and malignant B lineage cells. We have recently published exciting new data on how certain lipid mediators called "specialized proresolving lipid mediators" promote antibody production and thus may be a new class of vaccine adjuvants. These new lipid mediator adjuvants stimulate productive antibody production in both human cells and in preclinical animal models of infection. Our recent work focuses on enhancement of antibody responses to influenza virus and to HIV peptides. Techniques and areas of investigation: Flow cytometry, cell culture, cytokine biology, cell signaling, molecular biology, antibody production, translational research. Research funded by an NIH grant.

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